Hepatorenal protection during renal ischemia by quercetin and remote ischemic perconditioning

Mechanistic Aspects and Therapeutic Potential of Quercetin against COVID-19-Associated Acute Kidney Injury

“…Similarly, quercetin treatment improved renal function, evidenced by lessened renal pathologies, and lowered BUN and SCr levels, and histological integrity has been reported in an experimental model of renal ischemia and reperfusion (I/R) injury and sepsis-induced AKI, the most common causes of AKI in ICUs worldwide [21,53,115]. Gholampour and Sadidi [125] related that oral treatment with quercetin inhibited kidney dysfunction, characterized by a significant decrease in creatinine clearance and histological damages in the I/R-induced AKI, by clamping renal arteries for 45 min followed by 24 h reperfusion [125]. Previously, Shoskes [21] had reported the renoprotective properties of quercetin on ischemia/reperfusion in rats who underwent 30 min of left renal pedicle occlusion with simultaneous right nephrectomy [21].…”

“…The improvement of renal function promoted by quercetin treatment is accompanied by control of the oxidant-antioxidant balance [26,94]. Data from various studies with different nephrotoxic origins have shown that quercetin inhibits a decrease in glutathione peroxidase, superoxide dismutase, and catalase activities and an increase in malondialdehyde levels (lipid peroxidation) in AKI caused by toxins or drugs, ischemia/reperfusion, and sepsis [25,26,[125][126][127].…”

Combating Ischemia-Reperfusion Injury with Micronutrients and Natural Compounds during Solid Organ Transplantation: Data of Clinical Trials and Lessons of Preclinical Findings

“…Similar results were obtained in the case of quercetin. In animal models, a decrease of oxidative stress after IRI was observed [ 91 , 97 , 98 , 99 ], reflected by lower levels of thiobarbituric acid reactive substances (TBARS) [ 100 ] and MDA [ 101 ] as well as an increased activity of antioxidant enzymes [ 101 ]. Additionally, the inhibition of IRI-induced inflammation [ 91 , 99 ] and apoptosis/ferroptosis [ 99 , 102 ], as well as the induction of autophagy [ 103 ], finally resulting in decreased tissue damage, and improved organ function has been observed [ 97 , 98 , 102 ].…”

“…However, a variety of preclinical studies have shown its putative benefits in hepatic IRI. Thereby, improved plasma levels of liver enzymes AST, ALT [ 98 , 104 ] and the amelioration of oxidative stress [ 104 , 105 ], along with the inhibition of apoptosis, autophagy [ 106 ] and attenuation of liver injury [ 98 , 105 ], have been reported. Moreover, quercetin synergistically increased the protective effects of remote ischemic reperfusion preconditioning [ 98 ], as well as of the Fe 2+ chelator deferoxamine [ 107 ].…”

“…[183,184] p.o. [185] improved organ function increased graft survival [183,184] anti-inflammatory effects shift towards Treg via activation of PPARγ [183,184] inhibition of macrophage recruitment [185] inhibition of MCP-1/IP-10 [185] improved organ function improved shortening of isograft [202] decreased serum LDH [202] improved liver biomarkers (AST, ALT) [202] anti-inflammatory effects decreased serum TNFα [202] decreased serum IL-1 [202] anti-oxidative stress increased SOD activity [202] increased SOD/LPO [202] Quercetin Kidney rat [91,[98][99][100][101] pig [97] in vitro [102] mouse [103] i.p. [91,[98][99][100][101]103] preservation solution [97] anti-oxidative effects [91,[97][98][99] decrease of TBARS [100] decreased MDA [101] increased level of antioxidant enzymes [101] anti-inflammatory effects [91,99] anti-apoptotic effects [99,102] induction of autophagy [103] Liver rat [98,<...>…”