Hepatorenal injury induced by cutaneous application of<i>Atractylis gummifera</i>L

Bouziri, Asma; Hamdi, Abdelaziz; Menif, Khaled; Jaballah, Nejla Ben

doi:10.3109/15563650.2010.498379

Cited by 12 publications

(10 citation statements)

References 6 publications

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“…More than hundred cases of liver and renal injury associated with A. gummifera ingestion have been reported, and they frequently involved children . In addition, toxicity is reported with the cutaneous application . The onset of toxicity usually begins within few hours after ingestion, and is characterised by headache, anxiety, vomiting, abdominal pain, diarrhoea, and convulsion, which then often leads to acute liver and renal failure, neurovegetative state and death .…”

Section: Herbal Products That Have Been Linked To Hepatotoxicitymentioning

confidence: 99%

“…In addition, toxicity is reported with the cutaneous application . The onset of toxicity usually begins within few hours after ingestion, and is characterised by headache, anxiety, vomiting, abdominal pain, diarrhoea, and convulsion, which then often leads to acute liver and renal failure, neurovegetative state and death . There is no specific pharmacological treatment for A. gummifera intoxication available and all the current therapeutic approaches are only symptomatic, with LT being an option.…”

Section: Herbal Products That Have Been Linked To Hepatotoxicitymentioning

confidence: 99%

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Review article: herbal and dietary supplement hepatotoxicity

Bunchorntavakul

Reddy

2012

Aliment Pharmacol Ther

268

191

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Summary Background Herbal and dietary supplements are commonly used throughout the World. There is a tendency for underreporting their ingestion by patients and the magnitude of their use is underrecognised by Physicians. Herbal hepatotoxicity is not uncommonly encountered, but the precise incidence and manifestations have not been well characterised. Aims To review the epidemiology, presentation and diagnosis of herbal hepatotoxicity. This review will mainly discuss single ingredients and complex mixtures of herbs marketed under a single label. Methods A Medline search was undertaken to identify relevant literature using search terms including ‘herbal’, ‘herbs’, ‘dietary supplement’, ‘liver injury’, ‘hepatitis’ and ‘hepatotoxicity’. Furthermore, we scanned the reference lists of the primary and review articles to identify publications not retrieved by electronic searches. Results The incidence rates of herbal hepatotoxicity are largely unknown. The clinical presentation and severity can be highly variable, ranging from mild hepatitis to acute hepatic failure requiring transplantation. Scoring systems for the causality assessment of drug‐induced liver injury may be helpful, but have not been validated for herbal hepatotoxicity. Hepatotoxicity features of commonly used herbal products, such as Ayurvedic and Chinese herbs, black cohosh, chaparral, germander, greater celandine, green tea, Herbalife, Hydroxycut, kava, pennyroyal, pyrrolizidine alkaloids, skullcap, and usnic acid, have been individually reviewed. Furthermore, clinically significant herb–drug interactions are also discussed. Conclusions A number of herbal medicinal products are associated with a spectrum of hepatotoxicity events. Advances in the understanding of the pathogenesis and the risks involved are needed to improve herbal medicine safety.

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Section: Herbal Products That Have Been Linked To Hepatotoxicitymentioning

confidence: 99%

Section: Herbal Products That Have Been Linked To Hepatotoxicitymentioning

confidence: 99%

Review article: herbal and dietary supplement hepatotoxicity

Bunchorntavakul

Reddy

2012

Aliment Pharmacol Ther

268

191

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“…This plant is a life-threatening poisoning where all plant parts are toxic (240). Moreover, A. gummifera has been associated with several cases of hepatotoxicity including hepato-renal injury (89), hepatic necrosis (91) and death (91,95). Moreover, two main constituents are responsible for A. gummifera toxicity, which are atractylosides and gummiferin.…”

Section: Discussionmentioning

confidence: 99%

“…A. gummifera root extract is commonly used as antipyretic, diuretic, emetic and purgative as well as chewing gum (92,93). However, it is a well known life-threatening poisoning (89). The intoxication with A. gummifera was first described by Lefrane since 1866 (90).…”

Section: Atractylis Gummiferamentioning

confidence: 99%

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Hepatotoxic Botanicals - An Evidence-based Systematic Review

Abdualmjid

Sergi

2013

J Pharm Pharm Sci

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-Purpose. Herbal medicines have been increasingly used worldwide. However, the potential harms of these herbs have been noticed most recently following hepatotoxicity with ingestion of herbal remedies. The aim of this review is to evaluate the evidence of hepatotoxic effects linked to use of herbal preparations. Method. Electronic search was performed by searching several databases: PubMed, HerbMed, Google Scholar, Scopus, Cochrane Database of Systematic Reviews and Cochrane Library using both Latin and common names of several herbs. Language was restricted to English and articles were selected for relevance reporting incidence of hepatotoxicity associated with use of herbal products in human. Results. From a total of 565 relevant reviews and articles, 254 met our inclusion criteria and were analyzed.

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