Hepatoprotective Role of Thymol in Drug-Induced Gastric Ulcer Model

Geyikoğlu, Fatime; Yilmaz, Elif Gülcan; Erol, Hüseyin Serkan; Koç, Kübra; Çeriğ, Salim; Özek, Nihal Şimşek; Aysin, Ferhunde

doi:10.5604/01.3001.0012.7198

Cited by 28 publications

(33 citation statements)

References 40 publications

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“…[31] Recently, thymol was shown to have antifungal, anticancer, antibacterial and hepatoprotective activities. [32][33][34][35] Thus, thymol can be used to inhibit oral bacteria and as an antioxidant in food preservation. Moreover, thymol has also been reported as a therapy for wound repair.…”

Section: Identification Of the Volatile Compoundsmentioning

confidence: 99%

Comparison of the bioactive chemical components and antioxidant activities in three tissues of six varieties of Citrus grandis ‘Tomentosa’ fruits

Fan

Zhu

Qiu

et al. 2019

International Journal of Food Properties

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Section: Identification Of the Volatile Compoundsmentioning

confidence: 99%

Comparison of the bioactive chemical components and antioxidant activities in three tissues of six varieties of Citrus grandis ‘Tomentosa’ fruits

Fan

Zhu

Qiu

et al. 2019

International Journal of Food Properties

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“…A computational approach indicated that apigenin was predicted to have antifibrotic activity [ 96 ]. Thymol significantly ameliorated liver injury due to endotoxicity in gastric ulcer rat models [ 97 ]; however, the role played by thymol in liver fibrosis remains uncertain.…”

Section: Discussionmentioning

confidence: 99%

Wild Bitter Melon Extract Regulates LPS-Induced Hepatic Stellate Cell Activation, Inflammation, Endoplasmic Reticulum Stress, and Ferroptosis

Huang

Sun

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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The activation of hepatic stellate cells (HSCs) is a key component of liver fibrosis. Two antifibrosis pathways have been identified, the reversion to quiescent-type HSCs and the clearance of HSCs through apoptosis. Lipopolysaccharide- (LPS-) induced HSCs activation and proliferation have been associated with the development of liver fibrosis. We determined the pharmacological effects of wild bitter melon (WM) on HSC activation following LPS treatment and investigated whether WM treatment affected cell death pathways under LPS-treated conditions, including ferroptosis. WM treatment caused cell death, both with and without LPS treatment. WM treatment caused reactive oxygen species (ROS) accumulation without LPS treatment and reversed the decrease in lipid ROS production in HSCs after LPS treatment. We examined the effects of WM treatment on fibrosis, endoplasmic reticulum (ER) stress, inflammation, and ferroptosis in LPS-activated HSCs. The western blotting analysis revealed that the WM treatment of LPS-activated HSCs induced the downregulation of the connective tissue growth factor (CTGF), α-smooth muscle actin (α-SMA), integrin-β1, phospho-JNK (p-JNK), glutathione peroxidase 4 (GPX4), and cystine/glutamate transporter (SLC7A11) and the upregulation of CCAAT enhancer-binding protein homologous protein (CHOP). These results support WM as an antifibrotic agent that may represent a potential therapeutic solution for the management of liver fibrosis.

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“…Hydromethanolic extract of leaves of A . triplinervis pretreatment resulted antiulcer activity by significant diminution of ulcer manifestation parameters, ulcer score and UI (Musumba et al., 2009) by significant elevation of prostaglandin production (Abood et al., 2014; Geyikoglu et al., 2019) as prostaglandin has a significant protection on the stomach mucosa and thus suppress mucosal lesion (Musumba et al., 2009).…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective effect of hydromethanolic extract of Ayapana triplinervis leaves on indomethacin‐induced gastric ulcer in male Wistar rats

et al. 2021

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This study investigated the gastroprotective effect of Ayapana triplinervis leaves against indomethacin‐induced gastric ulcer in male albino rat. Gastric ulceration was developed by single oral dose of indomethacin (30 mg/kg). Experimental rats were pretreated with omeprazole (positive control 20 mg/kg), hydromethanolic extract of A. triplinervis (200 mg/kg) for 28 days just before the indomethacin treatment. Free acidity, total acidity, pepsin activity and gastric volume, gastric pH, tumor necrosis factor‐alpha (TNF‐α), interleukin‐6 (IL‐6) in stomach and serum prostaglandin E2 levels were assessed in control, ulcerated group and A. triplinervis pretreated groups. Oxidative stress biomarkers, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum also evaluated. All the parameters were deviated from control in indomethacin‐treated group but significantly protected in A. triplinervis–pretreated group. The active ingredient(s) present in the A. triplinervis have antioxidant and gastroprotective properties that prevent the indomethacin‐induced gastric ulcer. Practical applications A. triplinervis has been widely consumed from earlier time as traditional medicine for the treatment of gastric problem and gastric ulcer in India. This is the first report that hydromethanolic extract of A. triplinervis has potent therapeutic properties against gastric ulcer. This work will provide a clue to the pharmaceutical industry to develop an effective gastroprotective agent.

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Hepatoprotective Role of Thymol in Drug-Induced Gastric Ulcer Model

Cited by 28 publications

References 40 publications

Comparison of the bioactive chemical components and antioxidant activities in three tissues of six varieties of Citrus grandis ‘Tomentosa’ fruits

Comparison of the bioactive chemical components and antioxidant activities in three tissues of six varieties of Citrus grandis ‘Tomentosa’ fruits

Wild Bitter Melon Extract Regulates LPS-Induced Hepatic Stellate Cell Activation, Inflammation, Endoplasmic Reticulum Stress, and Ferroptosis

Gastroprotective effect of hydromethanolic extract of Ayapana triplinervis leaves on indomethacin‐induced gastric ulcer in male Wistar rats

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