Hepatoprotective Properties of Selected Plants Against Paracetamol-Induced Hepatotoxicity in Mice

Abstract

The hepatoprotective properties of the ethanolic extracts of Punica granatum peels, Crataeva religiosa leaves and Jasminum polyanthrum leaves were evaluated for the paracetamol induced liver toxicity in mice. Antioxidant, cytotoxicity and phytochemical screening were carried out to assure the therapeutic efficacy of these plants. Oral administration of plant extracts for 7 days in mice significantly reduced the impact of paracetamol toxicity on the serum markers of liver damage, aspartate transaminase (AST), alanine transaminase (ALT) and total protein. The extract showed significant hepatoprotective effects as evidenced by decreased serum enzyme activities like ALT, AST and changed total protein. The phytochemical and antioxidant studies also supported that plant extract markedly reduced the toxicity due to presence of antioxidant phytochemicals. The result suggests that Jasminum polyanthrum is potent hepatoprotective agent against paracetamol induced hepatotoxicity in mice.

Hepatoprotective effects of walnut oil and Caralluma tuberculata against paracetamol in experimentally induced liver toxicity in mice

“…Liver damage due to paracetamol is assessed by the increased level of ALT, when the liver is damaged it leaks out into the blood circulation (Ukpabiugo et al, 2016). An elevated level of ALT after feeding the mice with paracetamol was also observed by (Gyawali et al, 2017) C. tuberculata is a succulent, angular, and leafless plant that flourishes in the wild (Sultan et al, 2014). Caralluma is used as a hepatoprotective, anti-inflammatory, antiulcerogenic, anti-nociceptive and antioxidant (Kumar et al, 2018).…”