Hepatoprotective Potential of Calcium and Magnesium Against Cadmium and Lead Induced Hepatotoxicity in Wistar Rats

Dabak, Jonathan D.; Gazuwa, Samuel Y.; Ubom, Gregory A.

doi:10.3923/ajbkr.2009.12.19

Cited by 21 publications

(12 citation statements)

References 7 publications

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“…This result in agreement with previous studied, which carried on exposure to mercury chloride [110–114], and Ni [115]. Furthermore, this agrees with several investigators which reported that Cd and Pd administration increase aminotransferase, especially ALT, as a result of the necrotic lesion in the liver [114, 116, 117]. As seen in Figure 7(b), on the other hand, lead overloads stimulated oxidative damage in the liver tissue by causing oxidation of lipid.…”

Section: Discussionsupporting

confidence: 93%

“…This observation may be as a result of the injury inflicted on the liver; thereby making the proteins synthesized in the liver and spill out into the blood [116]. Also, this result is compatible with [119, 120].…”

Section: Discussionmentioning

confidence: 53%

“…This suggests that the heavy metals, like cadmium and lead, occurs when present in toxic concentrations in the system, impair the protein synthesis in liver [116]. …”

Section: Discussionmentioning

confidence: 99%

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Pretreatment Hepatoprotective Effect of the Marine Fungus Derived from Sponge on Hepatic Toxicity Induced by Heavy Metals in Rats

Abdel-Monem

Abdel-Azeem

El-Ashry

et al. 2013

BioMed Research International

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The aim of this study was to evaluate the pretreatment hepatoprotective effect of the extract of marine-derived fungus Trichurus spiralis Hasselbr (TS) isolated from Hippospongia communis sponge on hepatotoxicity. Twenty-eight male Sprague-Dawley rats were divided into four groups (n = 7). Group I served as −ve control, group II served as the induced group receiving subcutaneously for seven days 0.25 mg heavy metal mixtures, group III received (i.p.) TS extract of dose 40 mg for seven days, and group IV served as the protected group pretreated with TS extract for seven days as a protection dose, and then treated with the heavy metal-mixture. The main pathological changes within the liver after heavy-metal mixtures administrations marked hepatic damage evidenced by foci of lobular necrosis with neutrophilic infiltration, adjacent to dysplastic hepatocytes. ALT and AST measurements show a significant increase in group II by 46.20% and 45.12%, respectively. Total protein, elevated by about 38.9% in induction group compared to the −ve control group, in contrast to albumin, decreased as a consequence of metal administration with significant elevation on bilirubin level. The results prove that TS extract possesses a hepatoprotective property due to its proven antioxidant and free-radical scavenging properties.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 53%

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Pretreatment Hepatoprotective Effect of the Marine Fungus Derived from Sponge on Hepatic Toxicity Induced by Heavy Metals in Rats

Abdel-Monem

Abdel-Azeem

El-Ashry

et al. 2013

BioMed Research International

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“…The increased activities of TBARS that were observed in the plasma of rats during Cd toxicity indicated a high degree of lipid peroxidation and oxidative stress. Although indirectly involved in the generation of free radicals, lipid peroxidation is considered a primary mechanism for Cd-induced toxicity [ 37 - 40 ]. The toxic effects of Cd are exerted through oxidative damage to cellular organelles by inducing the generation of ROS [ 41 ], which consist mainly of O 2 + , H 2 O 2 – and OH + [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Polyphenol-rich extract of Vernonia amygdalina (del.) leaves ameliorated cadmium-induced alterations in feeding pattern and urine volume of male Wistar rats.

Imafidon¹,

Akomolafe²,

Sanusi³

et al. 2015

J Intercult Ethnopharmacol

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Aim:To determine the effects of a polyphenol-rich extract of the leaves of Vernonia amygdalina (PEVA) on the feeding pattern of rats that are exposed to cadmium (Cd) toxicity.Materials and Methods:Thirty male Wistar rats, weighing 160-180 g, were divided into 6 groups of 5 rats each as follows; Group 1 received distilled water orally (0.2 ml a 100 g rats), daily, throughout the period of study. Group 2 received Cd alone (in the form of CdSO4) at 5 mg/kg/day via intraperitoneal route for 5 consecutive days. Group 3 were pre-treated with Cd as Group 2 and thereafter left untreated for a period of 4-week. After the oral lethal dose of PEVA was determined, Groups 4, 5, and 6 received graded doses of PEVA at 100, 200 and 400 mg/kg/day (0.2 ml per 100 g rats), respectively via oral route for 4 weeks after they were pre-treated with Cd as Group 2. Blood samples were collected for some plasma biochemical assays while urine samples were collected using metabolic cages.Results:PEVA administration significantly increased (P < 0.05) the body weight and feeding patterns that were significantly reduced (P < 0.05) by Cd toxicity. PEVA also significantly reinstated the plasma antioxidant status, as well as glucose and urine volume of the rats toward control values (P < 0.05).Conclusion:PEVA can be an herbal alternative in the treatment or management of subjects manifesting alterations in feeding pattern and urine volume that is Cd-induced.

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“…Ge also possesses antioxidative property [9] and suppresses tumor progression [10]. In addition, beneficial effects of Se, Ge, Sn, Mg, and Ca on liver function have been reported [11,12,13,14].…”

Section: Introductionmentioning

confidence: 99%

Magma Seawater Inhibits Hepatic Lipid Accumulation through Suppression of Lipogenic Enzymes Regulated by SREBPs in Thioacetamide-Injected Rats

et al. 2019

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Thioacetamide (TAA) is known to induce lipid accumulation in the liver. In the present study, we investigated the effects of magma seawater (MS) rich in minerals on hepatic lipid metabolism by evaluating lipogenic enzymes regulated by sterol regulatory element-binding proteins (SREBPs). Rats (n = 10 per group) were intraperitoneally injected with TAA (200 mg/kg bw) thrice a week for seven weeks in combination with a respective experimental diet. Rats in the TAA-treated group received either a chow diet (Control group) or a chow diet containing MS (TMS group, 2.05%) or silymarin (TSM group, 0.05%). Rats in the normal group were injected with PBS as a vehicle and received a chow diet. Rats in the TMS group showed significantly lower hepatic lipid concentrations than rats in the control group (p < 0.05). Hepatic protein expression levels of fatty acid synthase, SREBP-1, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and SREBP-2 were significantly downregulated in the TMS group, whereas carnitine palmitoyltransferase 1 levels were upregulated (p < 0.05). Hepatic thiobarbituric acid reactive substances levels were lower in the TMS group, whereas protein levels of glutathione peroxidase and catalase were elevated (p < 0.05). The effects of MS were comparable to those of silymarin. Our results evidently showed that MS inhibits hepatic lipid accumulation by suppressing lipid synthesis, accompanied by lipid oxidation and elevation of antioxidative status.

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Hepatoprotective Potential of Calcium and Magnesium Against Cadmium and Lead Induced Hepatotoxicity in Wistar Rats

Cited by 21 publications

References 7 publications

Pretreatment Hepatoprotective Effect of the Marine Fungus Derived from Sponge on Hepatic Toxicity Induced by Heavy Metals in Rats

Pretreatment Hepatoprotective Effect of the Marine Fungus Derived from Sponge on Hepatic Toxicity Induced by Heavy Metals in Rats

Polyphenol-rich extract of Vernonia amygdalina (del.) leaves ameliorated cadmium-induced alterations in feeding pattern and urine volume of male Wistar rats.

Magma Seawater Inhibits Hepatic Lipid Accumulation through Suppression of Lipogenic Enzymes Regulated by SREBPs in Thioacetamide-Injected Rats

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