Hepatoprotective phenylethanoid glycosides from Cirsium setosum

Abstract

Two new phenylethanoid glycosides, namely β-D-glucopyranoside, 1″-O-(7S)-7-(3-methoxyl-4-hydroxyphenyl)-7-methoxyethyl-3″-α-L-rhamnopyranosyl-4″-[(8E)-7-(3-methoxyl-4-hydroxyphenyl)-8-propenoate] (1) and β-D-glucopyranoside, 1″-O-(7S)-7-(3-methoxyl-4-hydroxyphenyl)-7-methoxyethyl-3″-α-L-rhamnopyranosyl-4″-[(8E)-7-(4-hydroxyphenyl)-8-propenoate] (2), together with six phenylethanoid glycosides were isolated from Cirsium setosum. Their structures were elucidated by their spectroscopic data and references. Compounds 2, 4, 5, 7 and 8 (10 μM) exhibited moderate hepatoprotective activities. Compounds (3-8) were obtained from this plant for the first time.

Novel caffeoylquinic acid derivatives from Lonicera japonica Thunb. flower buds exert pronounced anti-HBV activities

“…To clarify the anti-HBV activity of caffeoylquinic acids from the ower buds of L. japonica Thunb., as well as four new caffeoylquinic acids (1)(2)(3)(4), together with ve simple caffeic acids (5)(6)(7)(8)17), and fourteen known caffeoylquinic acids (9)(10)(11)(12)(13)(14)(15)(16)(18)(19)(20)(21)(22)(23) are systematically isolated and identied ( Fig. 1).…”

UHPLC–MS/MS determination and pharmacokinetic study of plantamajoside in rat plasma after oral administration of single plantamajoside and Plantago asiatica extract

“…Phytochemical studies show that abundant compounds exist in P. asiatica , such as phenylethanoid glycosides (Miyase et al, ), phenolics (Ravn, Nishibe, Sasahara, & Xuebo, ) and various polysaccharides (Yin et al, ), among which phenylethanoid glycosides are the main components of this herb (Li, Liu, Liu, Tsao, & Liu, ; Li, Liu, Liu, & Wang, ). Phenylethanoid glycosides are widely distributed in the plant kingdom, and have been reported to possess various biological activities including antibacterial, cytotoxic, antioxidant, hepaprotective and immunomodulatory properties (Ma et al, ; Nazemiyeh et al, ).…”

“…Phenylethanoid glycosides are widely distributed in the plant kingdom, and have been reported to possess various biological activities including antibacterial, cytotoxic, antioxidant, hepaprotective and immunomodulatory properties (Ma et al, 2015;Nazemiyeh et al, 2008).…”

The complete chloroplast genome of Cirsium setosum and its phylogenetic analysis

“…Cirsium setosum is an edible medicinal plant that is widely distributed around the world. It is an important medicinal component in traditional Chinese medicine for many years, which was supported by considerable clinical evidence (Ma et al 2016a). For instance, C. setosum is widely used to treat many types of diseases, including incomplete uterine contraction and bleeding, infectious hepatitis, digestive tract bleeding, cardiovascular disease, and promote aggregation and adhesion of platelets (Lu et al 2015;Ma et al 2016a).…”

“…For instance, C. setosum is widely used to treat many types of diseases, including incomplete uterine contraction and bleeding, infectious hepatitis, digestive tract bleeding, cardiovascular disease, and promote aggregation and adhesion of platelets (Lu et al 2015;Ma et al 2016a). Modern phytochemical studies revealed that triterpenes, flavonoids, sterols, polyphenols, and glycosides are its main medicinal ingredients (Luan et al 2016;Ma et al 2016b;Ma, Wen, et al 2016). However, little is known in its biosynthesis mechanism.…”