Hepatoprotective Impact of Geraniol Against CCl4-Induced Liver Fibrosis in Rats

Geraniol ve vitamin C’nin dietilnitrozamin kaynaklı deneysel hepatoselüler karsinogenez üzerindeki etkisi

“…In this way, the effect of essential oils would be better understood and thus, the use of the drug would contribute to the fight against cancer and/or cardiovascular diseases. In our study, which was similar to the results of previous studies on geraniol 13,[16][17][18][19][20] , it was observed that geraniol suppressed cells by showing an antiproliferative effect in DENA sourced hepatocellular carcinoma cells. It is believed that geraniol may be beneficial in the development of cancer treatments and will provide a scientific basis for future research.…”

“…Previous studies include the ones examining the protective effect of geraniol against liver damage in cell lines, humans, and experimental animals 12,14,[16][17][18][19] . There was no study in which geraniol and vitamin C were used together in hepatocellular carcinoma formed by DENA in mouse hepatocyte cell line.…”

“…In this study, hepatocellular carcinoma formation was provided by inducing FL83B hepatocyte cell lines with DENA. In a study, Azap et al conducted on rats, the effects of geraniol on CCl4-induced liver fibrosis were investigated and as a result, it was stated that its hepatoprotective upshot on liver fibrosis 16 .…”

“…Besides its cosmetic use, geraniol has been shown to have some bioactive properties, including antiinflammatory, anti-angiogenesis, and anti-tumor effects [14][15][16][17][18][19] . The anti-tumor effect of geraniol has been demonstrated in cancer types of various organs such as the liver, lung, pancreas, and colon 12,13,[16][17][18][19][20][21][22] . This mechanism of geraniol, acyclic monoterpenoid alcohol, is by suppresses HMG-CoA reductase activity and stops the growth of co-cultured tumor cells 12,14 .…”

Geraniol prevents CCl4-induced hepatotoxicity via suppression of hepatic oxidative stress, pro-inflammation and apoptosis in rats

“…For example, studies have shown that CCl 4 induces hepatotoxicity and mitochondrial damage characterized by redox imbalance, inflammation and apoptosis with consistent histological necrosis and infiltration of inflammatory cells [25] , [34] , [7] . In recent studies, however, the role of CCl 4 -induced reactive oxygen species (ROS), pro-inflammation and altered signalling cascades in hepatic fibrosis have been confirmed [22] , [24] , [8] . Therefore, antioxidants such as natural polyphenols with known anti-inflammatory potentials may exert inhibitory effects against CCl 4 hepatotoxicity.…”