Hepatoprotective efficacy of Nigella sativa seeds dietary supplementation against lead acetate-induced oxidative damage in rabbit – Purification and characterization of glutathione peroxidase

El‐Far, Ali H.; Korshom, M. A.; Mandour, Abdelwahab; Elbessoumy, Ashraf A; El‐Sayed, Yasser S.

doi:10.1016/j.biopha.2017.02.044

Cited by 28 publications

(19 citation statements)

References 55 publications

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“…Consequently, several in vivo studies were performed to confirm their beneficial qualities. Medicinal plants are resources of new drugs and many of the modern medicines that improve the health status of animals (El-Far et al, 2016b;El-Far et al, 2017). The active principles of essential oils act as a digestibility enhancer, balancing the gut microbiota and stimulating the secretion of endogenous digestive enzymes and thus improving the growth performance in poultry (Cross et al, 2007;Ayoub et al, 2011;Barakat et al, 2016;El-Far et al, 2016a).…”

Section: Introductionmentioning

confidence: 99%

Effect of Rosemary (Rosmarinus Officinalis) Dietary Supplementation in Broiler Chickens Concerning immunity, Antioxidant Status, and Performance

Ghozlan¹,

El‐Far²,

Sadek³

et al. 2017

AJVS

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Section: Introductionmentioning

confidence: 99%

Effect of Rosemary (Rosmarinus Officinalis) Dietary Supplementation in Broiler Chickens Concerning immunity, Antioxidant Status, and Performance

Ghozlan¹,

El‐Far²,

Sadek³

et al. 2017

AJVS

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“…Medicinal plants are resources of new drugs and many of the modern medicines that improve the health status of animals (El-Far et al, 2016b;El-Far et al, 2017). Thyme (Thymus vulgaris) is a flowering plant in the mint family Lamiaceae.…”

Section: Introductionmentioning

confidence: 99%

Impact of Dietary Thyme (Thymus Vulgaris) on Broiler Chickens Concerning Immunity, Antioxidant Status, and Performance

Abdel-Ghaney¹,

El‐Far²,

Sadek³

et al. 2017

AJVS

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Key words:Broilers, Immunity, Antioxidant, Performance, ThymeThe current study aimed to determine the immune and antioxidant status, and performance of broiler chickens fed diets supplemented with thyme (Thymus vulgaris) leaves powder, as an alternative growth promoter. Therefore, a total of 120 one-day-old Cobb chicks were fed for 35 days with four experimental diets containing thyme powder (0, 5, 10 and 15 g/kg: these were designated groups Control, Thyme I, Thyme II and Thyme III, respectively). The GC-MS analysis of n-hexane extract of thyme showed the presence of isocaryophyllene (33.73%) as a major active ingredient with other antioxidant ingredients. Serum total protein and globulin content was significantly increased in thyme-supplemented chicks at the 3 rd week and significantly increased in Thyme I and III at the 5 th week. Serum albumin and creatinine content and ALT activities were non-significantly increased in the thyme-supplemented chicks at the 3 rd and 5 th weeks. Moreover, serum total cholesterol and triacylglycerol levels were significantly decreased in the thyme groups at the 3 rd and 5 th weeks. Dietary thyme supplementation for broiler was significantly improved serum IgG, IgM, INF-γ, and IL-10 levels, and muscle glutathione content, superoxide dismutase, and glutathione S-transferase with significantly reduced malondialdehyde levels. Regarding to growth performance, thyme 0.5% was non-significantly improved the final body weight, body weight gain, feed conversion ratio, and protein efficiency ratio of broiler chicks. So, these data indicated that incorporation of thyme into the broiler's diet was improved the immune status and antioxidant activities in broilers. Also, production of broilers meat with low levels of lipid peroxidation products. Corresponden ce to: * doaavet792016

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“…Roopha and Padmalata (2012) reported that continuous exposure to cadmium (Cd) for 45 and 65 days decreased the activity of SOD, CAT, and a GPx in rats. El-Far, Korshom, Mandour, El-Bessouy, & El-Sayed (2017) also reported that induction of Pb-acetate in rats decreased MDA level and the activities of SOD, CAT, and GPx. The enzymatic activities gradually increased after being treated with an antioxidant, Nigella sativa.…”

Section: Introductionmentioning

confidence: 90%

<b>Synergetic effect of chitosan and vitamin C on the oxidative enzyme status in rat exposed to lead acetate

Marianti

Mahatmanti

2018

Acta Sci. Biol. Sci.

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This article discusses the research results on the synergetic effect of chitosan and vitamin C in overcoming free radical effect due to blood lead (Pb 2+ ) accumulation. Blood lead level and enzymatic activities of superoxide dismutase (SOD), catalase oxidase (CAT), and Glutathione peroxidase (GPx) were used as the main parameters. Thirty adult male albino rats were divided into six groups. Group 1 was normal control group; group 2 was the negative control group treated with lead acetate at 175 mg kg -1 body weight (BW). Group 3 was treated with 64 mg kg -1 BW of chitosan day -1 . Group 4, 5, and 6 were treated with chitosan and vitamin C combination at the dose of 100, 200, and 300 mg kg -1 BW, respectively. All groups were inducted using 175 mg kg -1 BW of Pb-acetate, excluding control group. Results showed that chitosan and vitamin C treatment at the dose of 300 mg kg -1 BW decreased blood Pb 2+ level in rats exposed to Pb-acetate. The combination also significantly increased enzymatic activities from SOD, CAT, and GPx compared to the other groups. In conclusion, the combination of chitosan and vitamin C could elevate the several antioxidative enzymes activities in Pb-acetate induced rats.Keyword: chitosan; antioxidative enzyme; lead-induced rat.Efeito sinérgico do chitosano e da vitamina C no estado da enzima oxidativa em ratos expostos ao acetato de chumbo RESUMO. Este artigo discute os resultados da pesquisa sobre o efeito sinérgico da quitosana e da vitamina C na superação do efeito dos radicais livres devido ao acúmulo de chumbo no sangue (Pb 2+ ). O nível de chumbo no sangue e as atividades enzimáticas de superóxido dismutase (SOD), catalase oxidase (CAT) e glutationa peroxidase (GPx) foram utilizados como parâmetros principais. Trinta ratos albinos adultos foram divididos em seis grupos. Grupo 1 foi grupo controle normal; o grupo 2 foi o grupo controle negativo tratado com acetato de chumbo a 175 mg kg -1 de peso corporal (PC). O grupo 3 foi tratado com 64 mg kg -1 PC de quitosana dia -1 . Os grupos 4, 5 e 6 foram tratados com combinação de quitosana e vitamina C nas doses de 100, 200 e 300 mg kg -1 PC, respectivamente. Todos os grupos foram induzidos usando 175 mg kg -1 de PC de Pb-acetato, excluindo o grupo controle. Os resultados mostraram que o tratamento com quitosana e vitamina C na dose de 300 mg kg -1 PC diminuiu o nível de Pb 2+ no sangue em ratos expostos ao acetato de Pb. A combinação também aumentou significativamente as atividades enzimáticas de SOD, CAT e GPx em comparação com os outros grupos. Em conclusão, a combinação de quitosana e vitamina C pode elevar as várias atividades das enzimas antioxidativas em ratos induzidos com acetato de Pb.Palavras-chave: enzima antioxidante; quitosana; rato induzido por chumbo.

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Hepatoprotective efficacy of Nigella sativa seeds dietary supplementation against lead acetate-induced oxidative damage in rabbit – Purification and characterization of glutathione peroxidase

Cited by 28 publications

References 55 publications

Effect of Rosemary (Rosmarinus Officinalis) Dietary Supplementation in Broiler Chickens Concerning immunity, Antioxidant Status, and Performance

Effect of Rosemary (Rosmarinus Officinalis) Dietary Supplementation in Broiler Chickens Concerning immunity, Antioxidant Status, and Performance

Impact of Dietary Thyme (Thymus Vulgaris) on Broiler Chickens Concerning Immunity, Antioxidant Status, and Performance

<b>Synergetic effect of chitosan and vitamin C on the oxidative enzyme status in rat exposed to lead acetate

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