Hepatoprotective effects of syringin on fulminant hepatic failure induced by D‐galactosamine and lipopolysaccharide in mice

Abstract

The prognosis for fulminant hepatic failure (FHF) still remains extremely poor with a high mortality and, therefore, better treatments are urgently needed. Syringin, a main active substance isolated from Eleutherococcus senticosus, has been reported to exhibit immunomodulatory and anti-inflammatory properties. In this study, we investigated the effects and underlying mechanisms of syringin on lipopolysaccharide (LPS) and D-galactosamine (D-GalN)-induced FHF in mice. Mice were administered syringin (10, 30 and 100 mg kg(-1), respectively) intraperitoneally (i.p) 30 min before LPS/D-GalN then mortality and liver injury were evaluated subsequently. We found that syringin dose-dependently attenuated LPS/D-GalN-induced FHF, as indicated by reduced mortality, inhibited aminotransferase and malondialdehyde (MDA) content, an increased glutathione (GSH) concentration and alleviated pathological liver injury. In addition, syringin inhibited LPS/D-GalN-induced hepatic caspase-3 activation and hepatocellular apoptosis, myeloperoxidase (MPO) activity and intercellular adhesion molecule-1 (ICAM-1) expression, as well as hepatic tissues tumor necrosis factor-alpha (TNF-α) production and NF-κB activation in a dose-dependent manner. These experimental data indicate that syringin might alleviate the FHF induced by LPS/D-GalN through inhibiting NF-κB activation to reduce TNF-α production.

Thymoquinone, a bioactive component of Nigella sativa Linn seeds or traditional spice, attenuates acute hepatic failure and blocks apoptosis via the MAPK signaling pathway in mice

“…The JNK-mediated cytochrome release might contribute to caspase-3 activation and the onset of apoptosis. 24,25 In addition, LPS can induce lethal liver failure when simultaneously administered with D-GalN. 23 LPS are characteristic components of the cell wall of Gram negative bacteria, LPS treated mice show cytotoxicity and liver injury.…”

Antipyretic and hepatoprotective potential of Tinospora crispa and investigation of possible lead compounds through in silico approaches

“…P a > 0.7 indicates the probability of pharmacological potential is rich with values 0.5 < P a <0.7 reflecting considerable pharmacological effects experimentally. P a < 0.5 shows less pharmacological activity (Goel, Singh, Lagunin, & Poroikov, 2011;Khurana, Ishar, Gajbhiye, & Goel, 2011).…”

A network pharmacology approach to determine active ingredients and rationality of herb combinations of Modified-Simiaowan for treatment of gout

“…However, Jatrorrhizine and Syringing, the main active components in PC , exhibit low DL values (19.65%, 14.64%). Considering their potential pharmacological effects (Hu et al, 2009;Gong et al, 2014), they were still adopted for the further targeting.…”