Hepatoprotective effects of propolis extract on carbon tetrachloride‐induced liver injury in rats

González, Ricardo; Corcho, I.; Remírez, Diadelis; Rodríguez, Sandra; Ancheta, Odelsa; Merino, Nelsón; González, Amnely; Pascual, Carlos

doi:10.1002/ptr.2650090207

Cited by 49 publications

(25 citation statements)

References 19 publications

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“…The pharmacological properties of different propolis preparations have been reported as antihepatotoxic (Gonzales et al, 1995), anticarcinogenic (El-khawaga et al, 2003), antioxidative (Russo et al, 2002), neuroprotective (Nakajima et al, 2007), antiinflammatory (Borrelli et al, 2002), antimicrobial (Kujumgiev et al, 1999;Scheller et al, 1999;Koo et al, 2000;Marcucci et al, 2001;Abd El Hadi and Hegazi, 2002;Kartal et al, 2003;Al-Waili, 2005;Boyanova et al, 2005;Papova et al, 2005) and antiviral. Pharmacological activity against several viral infections has been demonstrated, e.g.…”

Section: Introductionmentioning

confidence: 98%

Antiviral Activity and Mode of Action of Propolis Extracts and Selected Compounds

Schnitzler

Neuner

Nolkemper

et al. 2010

Phytotherapy Research

199

132

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Aqueous and ethanol extracts of propolis were analysed phytochemically and examined for their antiviral activity in vitro. Different polyphenols, flavonoids and phenylcarboxylic acids were identified as major constituents. The antiviral effect of propolis extracts and selected constituents, e.g. caffeic acid (1), p-coumaric acid (2), benzoic acid (3), galangin (4), pinocembrin (5) and chrysin (6) against herpes simplex virus type 1 (HSV-1) was analysed in cell culture. The 50% inhibitory concentration (IC(50)) of aqueous and ethanol propolis extracts for HSV-1 plaque formation was determined at 0.0004% and 0.000035%, respectively. Both propolis extracts exhibited high levels of antiviral activity against HSV-1 in viral suspension tests, plaque formation was significantly reduced by >98%. In order to determine the mode of antiviral action of propolis, the extracts were added at different times during the viral infection cycle. Both propolis extracts exhibited high anti-HSV-1 activity when the viruses were pretreated with these drugs prior to infection. Among the analysed compounds, only galangin and chrysin displayed some antiviral activity. However, the extracts containing many different components exhibited significantly higher antiherpetic effects as well as higher selectivity indices than single isolated constituents. Propolis extracts might be suitable for topical application against herpes infection.

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Section: Introductionmentioning

confidence: 98%

Antiviral Activity and Mode of Action of Propolis Extracts and Selected Compounds

Schnitzler

Neuner

Nolkemper

et al. 2010

Phytotherapy Research

199

132

View full text Add to dashboard Cite

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“…In general propolis is a glue-like natural resinous substances that honey bees collected from a large variety of plant seedling and buds, which is used in folk medicine of at least 300 years b. c. (Ghisalberti, 1979). Propolis is a mixture of waxes, sugars and plant exudates and its chemical composition in diff erent samples includes more than 300 compounds, so its biological properties are diverse and its composition is directly related to that of the bud exudates collected by bees (Ghisalberti, 1979;Markham et al, 1996;Bankova et al, 2000;Banskota et al, 2001), in the animal nutrition the propolis has been added in grains or extract form into animals feed mixture as supplemental diet as well as antibiotic (Ghisalberti, 1979;Pepeljnjak et al, 1985;Velikova et al, 2000), antifungal (Dimov et al, 1991;Murad et al, 2002), antiviral (Amoros et al, 1994), local anesthetic (Paintz and Metzner, 1979), anti infl ammatory (Strehl et al, 1993;Miyataka et al, 1997), antioxidant (Sun et al, 2000;Isla et al, 2001), hepatoprotective (Gonzales et al, 1995), immune stimulating (Dimov et al, 1991), and cytostatic (Frenkel et al, 1993;Banskota et al, 2001). Prytzyk et al (2003) and Wang et al (2004) were found that the propolis has a positive eff ect on feed intake, body weight aslo they that found the propolis content flavonoid which led to improvement meat antioxidant.…”

Section: Introductionmentioning

confidence: 99%

The Influence of Propolis as Supplement Diet on Broiler Meat Growth Performance, Carcass Body Weight, Chemical Composition and Lipid Oxidation Stability

Haščík¹,

Elimam²,

Kročko³

et al. 2015

Acta Univ. Agric. Silvic. Mendelianae Brun.

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The present experiment was aimed to study the eff ect of the propolis extract as supplement diet on the broiler chickens growth performance, breast and thigh weights, meat chemical composition and lipid oxidation stability. A total of 120 chicks in one day old, which were divided into 4 groups (n = 30) for 42 days.To the experimental groups were added propolis extract in doses of 200 mg.kg −1 (II), 300 mg.kg −1 (III) and 400mg.kg −1 (IV). At the end of the experiment the results were shown that the body weight gain a er 21 and 42 days has been increased and there were found signifi cant diff erences (P ≤ 0.05) between control and experimental groups also the feed intake has been increased and there were (P ≤ 0.05). The FCR was higher in the control group. The carcass body weight breast and thigh weights were increased and there were no signifi cant diff erences while, the abdominal fat and liver weights were decreased. No signifi cant diff erence was occurred on chemical composition of breast and thigh muscles, whereasthe muscle moisture tends to increase and fat content and energy value were decreased. Interestingly, thelipid oxidation stability measured as TBARS during the freezing storage for 6 months has been decreasedmalondialdehyde (MDA) in the experimental groups and there were found signifi cant (P ≤ 0.05) in the breast musclesbetween control group and experimental groups. From the present study were concluded a er administration the propolis extract that broilergrowth performance has been increased and the lipid oxidation (MDA) during the freezing storage (−18 °C) have been decreased.

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“…Recent publications have reported that PP has a protective effect on chemical-induced liver injury. For example, pretreatment of rats with an ethanol extract of PP produced a hepatoprotective effect on CCl 4 -induced liver damage in histopathological and biochemical findings (Merino et al, 1996;Gonzalez et al, 1995). This also reduced liver damage induced by AA in mice, and markedly decreased the elevation of serum transaminase and hepatocellular fatty degeneration caused by chronic alcohol abuse in rats (Gonzalez et al, 1994;Lin et al, 1997).…”

Section: Discussionmentioning

confidence: 91%

“…Several biological activities such as anticancer, antioxidative, antiinflammatory and antibiotic activities have been reported for PP and its constituents (Burdock, 1998). Recently an ethanol extract of PP was shown to protect against liver injury induced by hepatotoxicants such as CCl 4 , alcohol and acetaminophen (Gonzalez et al, 1994;1995;Merino et al, 1996;Lin et al, 1997).…”

Section: Introductionmentioning

confidence: 97%

The protective effects of Propolis on hepatic injury and its mechanism

Seo¹,

Park²,

Song³

et al. 2003

Phytotherapy Research

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Propolis (PP) is a sticky substance that is collected from plants by honeybees. The purpose of this study was to investigate the protective effects of PP on hepatotoxicity induced by acetaminophen (AA, paracetamol) and the mechanism of its hepatoprotective effect. In rat hepatocyte culture, pretreatment with PP (1, 10, 100, 200 and 400 microg/mL, 24 h) significantly decreased the cytotoxicity of AA (0.5 mm) in a dose-dependent manner. In mice, pretreatment with PP (10 and 25 mg/kg, p.o., 7 days) also decreased the mortality and the incidence and severity of hepatic necrosis induced by AA (400 mg/kg, i.p.). After treatment with PP for 7 days, the hepatic enzyme activities of cytochrome P450 monooxygenases (P450s), UDP-glucuronyltransferase, phenolsulphotransferase (PST), glutathione S-transferase (GST) were measured in both rats and mice. In rats, PP (50 and 100 mg/kg, p.o.) decreased the activity of P4502E1, but significantly increased the activities of GST and PST. On the other hand, in mice treated with PP (10 and 25 mg/kg, p.o.), the activities of P4501A2, 2B1, 3A4 and 2E1 were dramatically inhibited, and the activity of PST was significantly enhanced. These results suggest that PP has a protective effect on hepatic injury, and that its effect may be explained by inhibition of phase I enzymes and induction of phase II enzymes.

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Hepatoprotective effects of propolis extract on carbon tetrachloride‐induced liver injury in rats

Cited by 49 publications

References 19 publications

Antiviral Activity and Mode of Action of Propolis Extracts and Selected Compounds

Antiviral Activity and Mode of Action of Propolis Extracts and Selected Compounds

The Influence of Propolis as Supplement Diet on Broiler Meat Growth Performance, Carcass Body Weight, Chemical Composition and Lipid Oxidation Stability

The protective effects of Propolis on hepatic injury and its mechanism

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