Hepatoprotective Effects of <i>Thespesia lampas</i> Dalz & Gibs in CCl₄ Induced Liver Injury in Rats

Abstract

ABSTRACT:The extracts of the roots of Thespesia lampas (Malvaceae) were evaluated for hepatoprotective activity in rats by inducing chronic liver damage by subcutaneous injection of 50% v/v carbon tetrachloride in Tween 80 at a dose of 3ml/kg for a period of 4 weeks. The biochemical parameters like serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), alkaline phosphatase (ALP), serum bilirubin and total proteins were estimated to assess the liver function. Hepatic steatosis, centrilobular necrosis, and often swelling of the hepatic cytoplasm were observed in carbontetra chloride treated group, while these were completely absent in the extracts of T. lampas (300 mg/kg b.wt) treated groups (p<0.01). The present investigation established pharmacological evidence to support the folkloric claim of hepatoprotective activity of T. lampas.

Hepatoprotective activity of active fractions of Thespesia lampas Dalz and Gibs (Malvaceae)

“…In that study, the water extract of the plant root was reported to have more hepatoprotective activity than the methanol extract. [8] In this study, the ethanol extract was found to be better than the water extract.…”

Enzyme Inhibition and Antibiotics Properties of Six (6) Weeks Stable Chrysophyllum albidum Leaf Silver Nano-Particles

“…The nitric oxide radical scavenging capacity of the fractions was measured by Griess reaction, following Sangermeswaran et al [13]. Ascorbic acid was used as the reference standard.…”

Thespesialampas mediated green synthesis of silver and gold nanoparticles for enhanced biological applications

“…Thespesia lampas is not a well-known ethnomedical medicinal plant. The plant has been reported for various therapeutic properties including hepatoprotective ( Ambrose et al, 2012 ), antioxidant ( Sangameswaran et al, 2009 ), anthelmintic ( Kosalge and Fursule, 2009 ), anti-diabetic ( Jayakar and Sangameswaran, 2008 ), and antimicrobial studies ( Valsaraj et al, 1997 ). The root, stem, and leaves have been reported for anti-inflammatory, anthelmintic acidity, bleeding nose, bronchitis, carbuncle, cough, dysentery, fever, gonorrhea, sunstroke, and urinary complaints ( Adhikari et al, 2007 ).…”