Hepatoprotective effects of Justicia adhatoda L. against carbon tetrachloride (CCl4) induced liver injury in Swiss albino mice

Afzal, Umara

doi:10.5897/ajpp12.501

Cited by 10 publications

(2 citation statements)

References 25 publications

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“…It elevates the liver marker enzymes which were reduced due to the injury in the liver (78). The same results were also reproduced by another research by using whole plant powder drug, these records for its hepatoprotective activity and various liver disorders (79). The aqueous extract of leaves shows significant hepatoprotective activity induced by d-galactosamine in rats at a dose less than 100 mg/kg per oral (24).…”

Section: Hepatoprotective Activitysupporting

confidence: 69%

A systematic ethnobotanical review of Adhatoda vasica (L.), Nees.

Shoaib

2022

Cell Mol Biol (Noisy-le-grand)

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Adhatoda vasica (L.), Nees belonging to the family Acanthaceae is a shrub with opposite ascending branches. The plant has been used in the indigenous system of medicine in India for near about 2500 years. It is a well-known plant as a drug in Ayurvedic and Unani medicines. Traditionally it was used for the treatment of various acute and chronic diseases and showed strong pharmacological activity particularly for bronchial infections, cough, bacterial infections, reproductive disorders, cardiac diseases and many more. Various phytochemicals like alkaloids, flavonoids, tannins, etc. were obtained from Adhatoda vasica (A. vasica). The active constituent of the plant is vasicine, l-vasicinone, deoxyvasicine, maiontone, vasicinolone and vasicinol etc. This review consists of updated information on the phyto-constituents isolated from A. vasica and their potential role in the treatment of various ailments traditionally and medically. Based on the critical review it was concluded that there is not sufficient scientifically strong evidence to explain that A. vasica extract, could be harmful to human beings especially in pregnant women. Major data on traditional uses as well as toxicological studies, evaluated various correctness, relevance, importance, and reliability for the overall evaluation of A. vasica safety. Numerous clinical trials are conducted around the globe on the herbal formulations of vasaka. This review includes strong data about phytochemical and ethnopharmacological studies that indicate that A. vasica is a versatile native plant of the Indian subcontinent having a commercial reputation and thus can be encouraged for diversified applications like medicinal and other potential uses.

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Section: Hepatoprotective Activitysupporting

confidence: 69%

A systematic ethnobotanical review of Adhatoda vasica (L.), Nees.

Shoaib

2022

Cell Mol Biol (Noisy-le-grand)

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“…Drug made from the plant is known in Unani medicine as 'Munaffis-e-balgham', meaning expectorant and good for treating cold, cough, asthma, and chronic bronchitis [56] . The hepatoprotective effect of leaves and flowers of the plant has been demonstrated in Swiss albino mice with CCl 4 -induced liver injury [57] . Significant reduction of blood glucose and glycosylated hemoglobin have been reported with methanolic extract of leaves in Balb-C albino diabetic mice.…”

Section: Resultsmentioning

confidence: 99%

Medicinal plants and their uses by a folk medicinal practitioner of Matlab Upazila in Chandpur district, Bangladesh

Ahmed¹,

Jahan²,

Rahmatullah³

2023

J. Med. Plants Stud.

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Background: Bangladesh is a small developing country with the majority population still residing in villages; most villages lack many modern amenities like proper drinking water facilities, sanitation, and conventional (allopathic) doctors and hospitals. On the other hand, although it is getting lost with possibly every passing day, villagers have a long history of traditional medicinal practitioners, who are also known as folk medicinal practitioners or Kavirajes (in Bengali). Kavirajes for the most part use medicinal plants, which are locally available for treatment and thus saves the villagers from costly conventional treatment, the medicines of which are neither readily available nor affordable. Once common, Kavirajes are fast disappearing along with loss of their folk medicinal knowledge. This loss is irreparable because plants and their phytochemicals still form the basis for discovery of modern drugs. For more than a decade, we had been conducting ethnomedicinal surveys among folk and tribal medicinal practitioners of Bangladesh. Methods and Findings: Interviews were conducted of the only folk medicinal practitioner (FMP) in Matlab Upazila. Prior permission was obtained from the FMP. Interviews were conducted with the help of a semi-structured questionnaire, extensive discussions, and field trips to areas frequented by the FMP to collect medicinal plants. Information was noted carefully. Plants were pictured, and plant samples identified by a trained botanist following collection, drying and mounting onto herbarium sheets. We could obtain information on only ten formulations, which were used for treatment of respiratory disorders, gastrointestinal tract disorders, pain, dengue, diabetes, acne, fever, eye problems, jaundice, gonorrhea, sexual problems, and debility. Conclusions: The richness of folk medicinal practice can be glimpsed from the diversity of illnesses treated with just twelve medicinal plant species. Some of these plants urgently need scientific attention before plants and FMPs disappear altogether. The phytochemicals present in the plants can be sources of potential drugs, lead compounds, or scaffolds for better drugs.

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Pharmacological and Bioactive Basis of Adhatoda vasica L. Nees

Ali

Hakeem

2020

Scientific Explorations of Adhatoda Vasica

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Hepatoprotective effects of Justicia adhatoda L. against carbon tetrachloride (CCl4) induced liver injury in Swiss albino mice

Cited by 10 publications

References 25 publications

A systematic ethnobotanical review of Adhatoda vasica (L.), Nees.

A systematic ethnobotanical review of Adhatoda vasica (L.), Nees.

Medicinal plants and their uses by a folk medicinal practitioner of Matlab Upazila in Chandpur district, Bangladesh

Pharmacological and Bioactive Basis of Adhatoda vasica L. Nees

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