Hepatoprotective Effects of Ixora parviflora Extract against Exhaustive Exercise-Induced Oxidative Stress in Mice

Abstract

Ixora parviflora, a species of the Rubiaceae, is rich in polyphenols and flavonoids, and has been traditionally used as a folk medicine. An I. parviflora extract (IPE) has great antioxidant activity in vitro, including a scavenging effect on superoxide radicals, reducing power, and ferrous ion-chelating ability. However, whether IPE is efficacious against oxidative damage in vivo is not known. The purpose of this study was to determine the protective effects of IPE treatment on hepatic oxidative stress and antioxidant defenses after exhaustive exercise in mice. Fifty male C57BL/6 mice (6 week old) were randomly divided into five groups and designated a sedentary control with vehicle (C), and exhaustive exercise with vehicle (IPE0), low dosage (IPE10), medium dosage (IPE50) and high dosage (IPE100) of IPE at 0, 10, 50, and 100 mg/kg, respectively. After a single bout of exhaustive swimming exercise challenge, levels of blood ammonia

Plant Adaptogens: Natural Medicaments for 21stCentury?

“…It was proven that intense exercises resulted in increasing oxygen consumption, and caused oxidative stress as an additional result of increased reactive oxygen species production . Exogenous antioxidants are capable of preventing oxidative damage.…”

Effects of Chocolate Malt Drink Consumption Combined with Aerobic Dance Exercise on Blood Bone Metabolism Markers, Antioxidant Enzymes and Aerobic Capacity in Young Females

“…In a previous study conducted by Kan, et al, 29 it was found that the GPx activity was significantly increased with the supplementation of flavonoids after performing an exhaustive swimming exercise in mice. Tauler, et al, 30 also found that GPx activities were significantly increased after taking antioxidant diet supplementation combined with exercise training in amateur trained male athletes.…”

“…Several previous studies showed different finding with the present finding. For instance, Kan, et al, 29 found that SOD activity level was significantly increased with supplementation of polyphenols and flavonoids rich which is Ixora parviflora extract after an exhaustive swimming in mice. Miyazaki, et al, 26 also found that SOD activity was significantly increased after 12 weeks of intense training in young males.…”

The Inhibition of Oxidised Low-Density Lipoprotein-Induced Apoptosis of Macrophages by Recombinant Human Brain Natriuretic Peptide and the Underlying Mechanism

“…It is known that excessive production of free radicals can reduce the levels of antioxidant-associated enzymes and can lead to cell and tissue injury [28]. To mitigate the cumulative burden of oxidative stress and to attenuate the deleterious effects of ROS, cells generally utilise antioxidant defences and scavenge ROS and MDA.…”