Hepatoprotective effects of <i>Vaccinium arctostaphylos</i> against CCl<sub>4</sub>-induced acute liver injury in rats

Ravan, Alireza Pouyandeh; Bahmani, Mahdi; Basir, Hamid Reza Ghasemi; Salehi, Iraj; Oshaghi, Ebrahim Abbasi

doi:10.1515/jbcpp-2016-0181

Cited by 19 publications

(8 citation statements)

References 35 publications

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“…Liver injury induced by chemical reagents is mainly related to excessive formation of free radicals and peroxidation [ 31 , 32 ]. Lipid peroxidation can cause damage to the structure and function of mitochondria, accompanied by disorders of energy metabolism, and substance metabolism [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Oxaloacetate Ameliorates Chemical Liver Injury via Oxidative Stress Reduction and Enhancement of Bioenergetic Fluxes

Kuang

Han

et al. 2018

IJMS

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Chemical injury is partly due to free radical lipid peroxidation, which can induce oxidative stress and produce a large number of reactive oxygen species (ROS). Oxaloacetic acid is an important intermediary in the tricarboxylic acid cycle (TCA cycle) and participates in metabolism and energy production. In our study, we found that oxaloacetate (OA) effectively alleviated liver injury which was induced by hydrogen peroxide (H2O2) in vitro and carbon tetrachloride (CCl4) in vivo. OA scavenged ROS, prevented oxidative damage and maintained the normal structure of mitochondria. We further confirmed that OA increased adenosine triphosphate (ATP) by promoting the TCA production cycle and oxidative phosphorylation (OXPHOS). Finally, OA inhibited the mitogen-activated protein kinase (MAPK) and apoptotic pathways by suppressing tumor necrosis factor-α (TNF-α). Our findings reveal a mechanism for OA ameliorating chemical liver injury and suggest a possible implementation for preventing the chemical liver injury.

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Section: Discussionmentioning

confidence: 99%

Oxaloacetate Ameliorates Chemical Liver Injury via Oxidative Stress Reduction and Enhancement of Bioenergetic Fluxes

Kuang

Han

et al. 2018

IJMS

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“…Luo et al showed that some Chinese medicines such as Lonicerae Japonicae Flos (Jinyinhua), Radix saposhnikoviae (Fangfeng), Radix glycyrrhizae (Gancao), Fructus forsythia (Lianqiao), and Rhizoma Atractylodis Macrocephalae (Baizhu) are useful in the prevention of COVID-19 [42]. Some other herbal plants, through their antioxidant and anti-inflammatory activity might be considered as useful agents in the treatment of COVID-19 infection [43][44][45][46]. Furthermore, zinc nanoparticles, due to their potential antioxidant, anti-inflammatory [47], and antiviral effects, have been found to inhibit influenza viral load and COVID-19 replication in an in vitro experiment [48].…”

Section: Treatment Of Covid-19mentioning

confidence: 99%

Diagnosis and treatment of coronavirus disease 2019 (COVID-19): Laboratory, PCR, and chest CT imaging findings

Abbasi-Oshaghi

Mirzaei

Farahani

et al. 2020

International Journal of Surgery

103

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, more than 3 million cases of coronavirus disease 2019 (COVID-19) and about 200,000 deaths have been reported worldwide. The outbreak of this novel disease has become a global health emergency and continues to rapidly spread around the world. Based on the clinical data, approved cases are divided into four classes including mild, moderate, severe, and critical. About 5% of cases were considered critically ill and 14% were considered to have the severe classification of the disease. In China, the fatality rate of this infection was about 4%. This review focuses on currently available information on the etiology, clinical symptoms, diagnosis, and mechanism of action of COVID-19. Furthermore, we present an overview of diagnostic approaches and treatment of this disease according to available findings. This review paper will help the physician to diagnose and successfully treat COVID-19.

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“…The total phenolic content of the fruit of this plant is 164.9 mg GAC/g, is more than its leaves (60.1 mg QE/g) (Ayaz et al, ). This high phenolic content of this plant's fruit has made it one of the most important natural antioxidants to protect the liver from toxic compounds such as carbon tetrachloride (Ravan, Bahmani, Basir, Salehi, & Oshaghi, ). The aim of present study was to evaluate the protective effects of hydroalcoholic extract of this plant on testicular tissue using stereological principles, sperm parameters and antioxidant properties after OM damage.…”

Section: Introductionmentioning

confidence: 99%

The effects of hydroalcoholic extract of Vaccinium arctostaphylos L. on sperm parameters, oxidative injury and apoptotic changes in oxymetholone‐induced testicular toxicity in mouse

et al. 2020

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Anabolic androgenic steroids (AAS) such as oxymetholone (OM) used for athletic enhancement, but increased free radicals damage and changes in hormonal levels, lead to serious and irreversible organ damage. Vaccinium arctostaphylos(V. arctostaphylos( has been demonstrated to have antioxidant and antiinflammatory effects. The aim of present study was to investigate V. arctostaphylos effect on OM‐induced oxidative injury in mouse testis and sperm parameters. In this experimental study, 30 BALB/c mice were divided into five groups, including healthy, positive control(5 mg/kg OM) and three treatment groups (100, 200 and 400 mg/kg of V. arctostaphylos extract + 5 mg/kg OM). At the end of the study, serum luteinizing hormone (LH), follicle‐stimulating hormone (FSH) and testosterone levels were measured. Testis stereological and sperm parameters were calculated. Antioxidant status was measured using nitric oxide (NO) and FRAP assay, and malondialdehyde (MDA) levels. Furthermore, the expression of p53, caspase‐3, Bax and Bcl‐2 was measured. V. arctostaphylos decreased the serum level of testosterone, increased the LH and FSH, and improved the stereological and sperm parameters and down‐regulated the p53, caspase‐3 and Bax and up‐regulated Bcl‐2 genes. Furthermore, this dose decreased serum levels of NO and increased testis FRAP and MDA levels in treated groups compared with OM group. V. arctostaphylos extract has protective effects against testicular toxicity caused by OM.

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Hepatoprotective effects of Vaccinium arctostaphylos against CCl₄-induced acute liver injury in rats

Abstract: These findings suggested that V.a may be useful in the treatment and prevention of hepatic injury induced by CCl4.

Cited by 19 publications

References 35 publications

Oxaloacetate Ameliorates Chemical Liver Injury via Oxidative Stress Reduction and Enhancement of Bioenergetic Fluxes

Oxaloacetate Ameliorates Chemical Liver Injury via Oxidative Stress Reduction and Enhancement of Bioenergetic Fluxes

Diagnosis and treatment of coronavirus disease 2019 (COVID-19): Laboratory, PCR, and chest CT imaging findings

The effects of hydroalcoholic extract of Vaccinium arctostaphylos L. on sperm parameters, oxidative injury and apoptotic changes in oxymetholone‐induced testicular toxicity in mouse

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Hepatoprotective effects of Vaccinium arctostaphylos against CCl4-induced acute liver injury in rats

Abstract: These findings suggested that V.a may be useful in the treatment and prevention of hepatic injury induced by CCl4.

Cited by 19 publications

References 35 publications

Oxaloacetate Ameliorates Chemical Liver Injury via Oxidative Stress Reduction and Enhancement of Bioenergetic Fluxes

Oxaloacetate Ameliorates Chemical Liver Injury via Oxidative Stress Reduction and Enhancement of Bioenergetic Fluxes

Diagnosis and treatment of coronavirus disease 2019 (COVID-19): Laboratory, PCR, and chest CT imaging findings

The effects of hydroalcoholic extract of Vaccinium arctostaphylos L. on sperm parameters, oxidative injury and apoptotic changes in oxymetholone‐induced testicular toxicity in mouse

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Hepatoprotective effects of Vaccinium arctostaphylos against CCl₄-induced acute liver injury in rats