Hepatoprotective effects of Hibiscus, Rosmarinus and Salvia on azathioprine-induced toxicity in rats

Amin, Amr; Hamza, Alaaeldin Ahmed

doi:10.1016/j.lfs.2004.09.048

Cited by 158 publications

(103 citation statements)

References 43 publications

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“…Natural products have long been an important source of therapeutic agents for this purpose (Asha et al, 2007;Jain et al, 2008), and R. offi cinalis is well known for its antioxidant properties (Amin and Hamza, 2005;Rusu et al, 2005). Our studies using an experimental cirrhosis model have confi rmed these properties and provided evidence for the traditional use of R. offi cinalis as a hepatoprotective agent.…”

Section: Discussionsupporting

confidence: 64%

“…Rosmarinus offi cinalis (L.) (Labiatae) has been suggested as being of special interest as a hepatoprotector (Amin and Hamza, 2005). Its antioxidant activity is well documented (Wu et al, 1982) and the activity has been ascribed to both the diterpene content, mainly carnosic acid and carnosol (Wijeratne and Cuppett, 2007), as well as to the essential oil constituents (Bozin et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Oxidative stress modulation by Rosmarinus officinalis in CCl₄‐induced liver cirrhosis

Gutiérrez

Alvarado

Presno

et al. 2009

Phytotherapy Research

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Rosmarinus offi cinalis (Lamiaceae) possesses antioxidant activity and hepatoprotective effects, and so may provide a possible therapeutic alternative for chronic liver disease. The effect produced by a methanolic extract of Rosmarinus offi cinalis on CCl 4 -induced liver cirrhosis in rats was investigated using both prevention and reversion models. Over the course of the development of cirrhosis, the increased enzymatic activities of gammaglutamyl transpeptidase and alanine aminotransferase, and the rise in bilirubin levels caused by CCl 4 administration, were prevented by Rosmarinus offi cinalis co-administration. When the cirrhosis by oxidative stress was evaluated as an increase on liver lipoperoxidation, total lipid peroxides, nitric oxide in serum, and loss of erythrocyte plasma membrane stability, R. offi cinalis was shown to prevent such alterations. On cirrhotic animals treated with CCl 4 , histological studies showed massive necrosis, periportal infl ammation and fi brosis which were modifi ed by R. offi cinalis. These benefi ts on experimental cirrhosis suggest a potential therapeutic use for R. offi cinalis as an alternative for liver cirrhosis.

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Section: Discussionsupporting

confidence: 64%

Section: Introductionmentioning

confidence: 99%

Oxidative stress modulation by Rosmarinus officinalis in CCl₄‐induced liver cirrhosis

Gutiérrez

Alvarado

Presno

et al. 2009

Phytotherapy Research

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“…This is consistent with the previously reported data showing antihepatotoxic effect of oral administration of rosemary extracts. 71,72 The study of the molecular mechanism(s) underlying the in vivo antitumorigenic effects of Ro25-4020, rosemary extract and their combination in the WEHI-3B D 2 murine tumor model is now in progress in our laboratory, employing histochemical and immunohistochemical analysis of tumor sections obtained in the experiments described here. The results of our in vitro study show the cytostatic rather than cytotoxic nature of the VDD/carnosic acid and VDD/rosemary extract combinations.…”

Section: Discussionmentioning

confidence: 99%

Cooperative antitumor effects of vitamin D₃ derivatives and rosemary preparations in a mouse model of myeloid leukemia

Sharabani

Izumchenko

Wang

et al. 2006

Intl Journal of Cancer

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1a,25-dihydroxyvitamin D 3 (1,25D 3 ) is a powerful differentiation agent, which has potential for treatment of myeloid leukemias and other types of cancer, but the calcemia produced by pharmacologically active doses precludes the use of this agent in the clinic. We have shown that carnosic acid, the major rosemary polyphenol, enhances the differentiating and antiproliferative effects of low concentrations of 1,25D 3 in human myeloid leukemia cell lines (HL60, U937). Here we translated these findings to in vivo conditions using a syngeneic mouse leukemia tumor model. To this end, we first demonstrated that as in HL60 cells, differentiation of WEHI-3B D 2 murine myelomonocytic leukemia cells induced by 1 nM 1,25D 3 or its low-calcemic analog, 1,25-dihydroxy-16-ene-5,6-trans-cholecalciferol (Ro25-4020), can be synergistically potentiated by carnosic acid (10 lM) or the carnosic acid-rich ethanolic extract of rosemary leaves. This effect was accompanied by cell cycle arrest in G01G1 phase and a marked inhibition of cell growth. In the in vivo studies, i.p. injections of 2 lg Ro25-4020 in Balb/c mice bearing WEHI-3B D 2 tumors produced a significant delay in tumor appearance and reduction in tumor size, without significant toxicity. Another analog, 1,25-dihydroxy-16,23Z-diene-20-epi-26,27-hexafluoro-19-nor-cholecalciferol (Ro26-3884) administered at the same dose was less effective than Ro25-4020 and profoundly toxic. Importantly, combined treatment with 1% dry rosemary extract (mixed with food) and 1 lg Ro25-4020 resulted in a strong cooperative antitumor effect, without inducing hypercalcemia. These results indicate for the first time that a plant polyphenolic preparation and a vitamin D derivative can cooperate not only in inducing leukemia cell differentiation in vitro, but also in the antileukemic activity in vivo. These data may suggest novel protocols for chemoprevention or differentiation therapy of myeloid leukemia. ' 2006 Wiley-Liss, Inc.

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“…The greatest level of attention among herbs and spices as sources of antioxidants has been focused on rosemary [4]. Rosemary (Rosmarinus officinalis L.) is a perennial herb from Lamiaceae family, typical of the Mediterranean region, which has been believed have many potential biological and pharmacology functions, such as antioxidant, antimicrobial, hepatoprotective and antiproliferative [5][6][7][8][9]. Therefore, in this study, we investigate whether rosemary extract has the capacity to prolong the lifespan of D. melanogaster and its underlying molecular mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Rosemary Extract Mediated Lifespan Extension in Drosophila Melanogaster

Wang¹,

Zhang²,

Sun³

et al. 2016

Proceedings of the 2015 International Conference on Materials Chemistry and Environmental Protection (Meep-15)

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Abstract-Rosemary (Rosmarinus officinalis L.) has always known a versatile, aromatic herb and addition to being used as a food flavoring is also known medicinally for its powerful antioxidant activity, antibacterial and hepatoprotective properties. In this study we examined the effects of rosemary iextract on the lifespan and aging in Drosophila melanogaster against high-fat induced oxidative injury, and found that it responded to rosemary extract with an increased lifespan and reduced MDA content during aging. We found that lifespan extension by rosemary extract was attributed to its increasing the activity of SOD, CAT and decreasing the content of MDA. Moreover, Realtime-PCR analysis showed that the gene expression of SOD, and CAT was enhanced, in contrast MTH was significantly reduced. In conclusion, these results suggest that the antioxidant and antiaging effect of rosemary extract may, at least in part, be due to its interactions with endogenous antioxidant protective enzymes including SOD and CAT.

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Hepatoprotective effects of Hibiscus, Rosmarinus and Salvia on azathioprine-induced toxicity in rats

Cited by 158 publications

References 43 publications

Oxidative stress modulation by Rosmarinus officinalis in CCl₄‐induced liver cirrhosis

Oxidative stress modulation by Rosmarinus officinalis in CCl₄‐induced liver cirrhosis

Cooperative antitumor effects of vitamin D₃ derivatives and rosemary preparations in a mouse model of myeloid leukemia

Rosemary Extract Mediated Lifespan Extension in Drosophila Melanogaster

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Hepatoprotective effects of Hibiscus, Rosmarinus and Salvia on azathioprine-induced toxicity in rats

Cited by 158 publications

References 43 publications

Oxidative stress modulation by Rosmarinus officinalis in CCl4‐induced liver cirrhosis

Oxidative stress modulation by Rosmarinus officinalis in CCl4‐induced liver cirrhosis

Cooperative antitumor effects of vitamin D3 derivatives and rosemary preparations in a mouse model of myeloid leukemia

Rosemary Extract Mediated Lifespan Extension in Drosophila Melanogaster

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Product

Resources

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Oxidative stress modulation by Rosmarinus officinalis in CCl₄‐induced liver cirrhosis

Oxidative stress modulation by Rosmarinus officinalis in CCl₄‐induced liver cirrhosis

Cooperative antitumor effects of vitamin D₃ derivatives and rosemary preparations in a mouse model of myeloid leukemia