Hepatoprotective Effects of Aqueous Extract of Watermelon (Citrullus lanatus) Seeds on Ethanol-Induced Oxidative Damage in Wister Rats

Bazabang, Sebastine Anthony; Monday, Nwankwo; Adebisi, Samuel Sunday; Makena, Wusa; Iliya, Ibrahim Abdullahi

doi:10.4103/ssajm.ssajm_18_18

Cited by 11 publications

(2 citation statements)

References 3 publications

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“…Soften bowel contents. [ 87 ] Citrullus lanatus (Cucurbitac-eae) Aqueous extract of Seeds Wister rats Ethanol 200 and 400 mg/kg AST↓, ALT↓, ALP↓ Antioxidant [ 88 ] Clausena lansium ( Rutaceae) Methanolic extract of Stem bark Wistar rats Carbon tetrachloride 100 and 200 mg/kg ALP↓, ALT↓, AST↓ Used in coughs, asthma, gastro-intestinal diseases, ulcers, and vermifuge. [ 89 ] Cleome viscosa (Capparida-ceae) Ethanolic extract of Leaves Male albino rats Carbon tetrachloride 100 and 200 mg/kg b.w Total bilirubin↓, ALP↓, SGPT↓, SGOT↓ Used in diarrhea, fever, inflammation, bronchitis, skin diseases, and malarial fever.…”

Section: Hepatoprotective Potentials Of Medicinal Plants and Their Bi...mentioning

confidence: 99%

Medicinal herbs and their metabolites with biological potential to protect and combat liver toxicity and its disorders: A review

Islam Shawon,

Nargis Reyda,

Qais

2024

Heliyon

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Section: Hepatoprotective Potentials Of Medicinal Plants and Their Bi...mentioning

confidence: 99%

Medicinal herbs and their metabolites with biological potential to protect and combat liver toxicity and its disorders: A review

Islam Shawon,

Nargis Reyda,

Qais

2024

Heliyon

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“…The high content of antioxidants and dietary fiber in watermelon seeds may help to reduce the level of free radicals [47]. Furthermore, watermelon seeds have been reported to improve liver function based on their high level of bioactive components [73].…”

Section: Liver Histopathological Examinationmentioning

confidence: 99%

Remedial Action of Yoghurt Enriched with Watermelon Seed Milk on Renal Injured Hyperuricemic Rats

et al. 2022

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The consumption of plant-based dairy alternatives has increased rapidly around the world as a result of numerous positive health effects. Little information is available about the potential use of watermelon seed milk in the manufacture of yoghurt. The present study was undertaken to investigate the remedial action of yoghurt enriched with watermelon seed milk in renal injured hyperuricemic rats. A new yoghurt, substituting cow’s milk with different proportions of watermelon seed milk was prepared, followed by evaluation of its acceptability and functionality. Four different types of yoghurt were prepared from cow’s milk containing 3% fat, with different proportions of blended watermelon seed milk (0.0, 25, 50 and 75%). Sensorial traits, i.e., appearance, flavor, body and texture, and overall acceptability demonstrated that the blended treatment (50% cow’s milk and 50% watermelon seed milk.) was the most acceptable. This blend was then tested as an anti-hyperuricemia agent in rats. In this respect, twenty-four male albino rats were assigned into four groups (n = 6). The first group was solely administered a standard diet, and served as the negative control. The other rats (n = 18) received a basal diet including 20 g/kg dietary potassium oxonate in order to induce hyperuricemia. The hyperuricemic rats were then divided into three groups; the first group did not receive any treatment and served as the positive control, while the second and third groups were administered 10% cow’s milk yoghurt and 10% watermelon seed milk yoghurt, respectively. Interestingly, the results showed that the hyperuricemic group receiving a diet supplemented with 10% watermelon seed milk yoghurt was not significantly different from the negative control in the measured biological parameters, and saw a significant improvement in renal function compared to the positive control. The biologically favorable action of watermelon seed milk yoghurt could be attributed to its potential promotion of antioxidant status via enhancement of the activities of superoxide dismutase, catalase, and glutathione transferase. Collectively, this study concluded that watermelon seed milk can be used in yoghurt manufacturing in proportions of up to 50%, and may improve kidney function as an anti-hyperuricemic agent.

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Composition, bioactive potential and food applications of watermelon (citrullus lanatus) seeds – a review

Benmeziane,

Derradji

2023

Food Measure

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Hepatoprotective Effects of Aqueous Extract of Watermelon (Citrullus lanatus) Seeds on Ethanol-Induced Oxidative Damage in Wister Rats

Cited by 11 publications

References 3 publications

Medicinal herbs and their metabolites with biological potential to protect and combat liver toxicity and its disorders: A review

Medicinal herbs and their metabolites with biological potential to protect and combat liver toxicity and its disorders: A review

Remedial Action of Yoghurt Enriched with Watermelon Seed Milk on Renal Injured Hyperuricemic Rats

Composition, bioactive potential and food applications of watermelon (citrullus lanatus) seeds – a review

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