Hepatoprotective effect of α-mangostin against lipopolysaccharide/d-galactosamine-induced acute liver failure in mice

Fu, Tianhua; Li, Haijun; Zhao, Yan; Cai, Enbo; Zhu, Hongyan; Li, Pingya; Liu, Jinping

doi:10.1016/j.biopha.2018.07.034

Cited by 32 publications

(32 citation statements)

References 35 publications

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“…The results corroborated findings of the previous studies, where α-MG exhibited cardioprotective effects on isoproterenolinduced myocardial infarction (Sampath et al, 2007), renoprotective effects on cisplatin-induced nephrotoxicity (Pérez-Rojas et al, 2009), and hepatoprotective effects on acute liver failure (Fu et al, 2018). The antioxidative properties of α-MG are mediated by its phenol-rich content, which may act as a free radical scavenger as well as a modulator for several antioxidant enzymes (Ibrahim et al, 2016).…”

Section: Discussionsupporting

confidence: 89%

“…IR which is commonly followed by obesity can be induced in experimental animals by providing a high-fat diet for several weeks to months. However, there are several studies that prove that IR can be detected in rodents only after 1-3 weeks of high-fat diet before an increase in body mass (Castorena et al, 2014;Hancock et al, 2008;Turner et al, 2013). Figure 1.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 36 male Wistar rats with age ranging from 10 to 12 months (150-250 g) were bred and handled at the Institute of Health Research and Development, Faculty of Medicine, Universitas Indonesia, Jakarta. This study's protocol was approved by the Institute of Animal Studies Ethics Committee (Guo et al, 2018). Animals were housed in standard condition (12 hours light/ dark cycle; 23°C ± 2°C) and were provided with ad libitum access to food and water.…”

Section: Animalsmentioning

confidence: 99%

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Antioxidative activities of alpha-mangostin in high-fat/high-glucose diet and streptozotocin-induced insulin-resistant rodents

Lazarus¹,

Alexander²,

Kusuma³

et al. 2020

J Appl Pharm Sci

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Section: Animalsmentioning

confidence: 99%

See 1 more Smart Citation

Antioxidative activities of alpha-mangostin in high-fat/high-glucose diet and streptozotocin-induced insulin-resistant rodents

Lazarus¹,

Alexander²,

Kusuma³

et al. 2020

J Appl Pharm Sci

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“…Evidences have proved that TLR4, a member of TLR family, is the main receptor for the recognition of LPS and is quite vital in LPS-induced liver injury [21, 22]. It has reported that TLR4 upregulation functions in endotoxin-induced liver injury and decreases the mice survival rate after hepatectomy [21].…”

Section: Discussionmentioning

confidence: 99%

Apolipoprotein A5 alleviates LPS/d-GalN-induced fulminant liver failure in mice by inhibiting TLR4-mediated NF-κB pathway

Tao

Luo

et al. 2019

J Transl Med

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Background Fulminant liver failure (FHF) is a serious clinical problem and liver transplantation is the major intervention. But the overall survival rate of FHF is low owing to the donated organ shortage. Apolipoprotein A-V (ApoA5) is a regulator of triglyceride metabolism and has been reported to act as a predictor for remnant liver growth after preoperative portal vein embolization and liver surgery. This study aimed to investigate the therapeutic effect of ApoA5 on lipopolysaccharide/ d -galactosamine (LPS/ d -GalN)—induced fulminant liver failure in mice. Methods FHF mouse model was established using LPS/ d -GalN and ApoA5 plasmid was injected by tail vein prior to LPS/ d -GalN treatment. The expressions of ApoA5, toll-like receptor 4 (TLR4), myeloid differentiation factor 88 (MyD88), and nuclear factor kappa B p65 (NF-κBp65) were assessed by real-time PCR and western blotting. Serum alanine aminotransferase (ALT) and tumor necrosis factor-α (TNF-α) levels were measured using automatic biochemical analyzer. Histological assessment and immunohistochemical (IHC) staining were conducted. Survival rate after LPS/ d -GalN administration was also determined with Kaplan–Meier curve. Meanwhile, the expression of ApoA5 in injured huh7 cells was tested. Cell apoptosis analysis was performed after huh7 cells were transfected with ApoA5 plasmid and stimulated with LPS. Results The expressions of ApoA5 decreased both in injured huh7 cells and FHF mice. ApoA5 overexpression reduced cell death rate using flow cytometry. ApoA5 not only decreased the serum ALT and TNF-α levels but also attenuated hepatic damage in hematoxylin–eosin (HE)-stained liver section. The protein expressions of TLR4, MyD88 and NF-κBp65 were inhibited when ApoA5 overexpressed. But the inhibitory effect would weaken with the increasing concentration of LPS in spite of ApoA5 overexpression. Besides, ApoA5 improved liver injury in a dose-dependent manner and the survival rate in FHF mice increased with increasing concentration of ApoA5. Conclusion ApoA5 had a protective effect against LPS/ d -GalN-induced fulminant liver failure in mice within a certain range by inhibiting TLR4-mediated NF-κB pathway.

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“…C. tamala leaves extracts are potent antioxidants and are hepatoprotective against chemical-induced toxicity in rodents [8,27]. Recently, Fu et al reported that alpha-mangostin from the G. mangostana fruit rind extract activated antioxidant defense and parallelly induced anti-inflammatory response to protect lipopolysaccharide/d-galactosamine-induced liver toxicity in mice [28]. Kidneys eliminate urea and creatinine from the body through urine.…”

Section: Discussionmentioning

confidence: 99%

Acute, Subacute, and Genotoxicity Assessments of a Proprietary Blend of Garcinia mangostana Fruit Rind and Cinnamomum tamala Leaf Extracts (CinDura®)

Dodda

Alluri

Golakoti

et al. 2020

Journal of Toxicology

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The present communication describes a battery of toxicity studies that include an acute oral toxicity, a subacute twenty-eight-day repeated oral dose toxicity, and genotoxicity studies on a herbal formulation CinDura® (GMCT). This proprietary herbal composition contains the extracts of the Garcinia mangostana fruit rind (GM) and the Cinnamomum tamala leaf (CT). The toxicological evaluations were performed following the Organization for Economic Cooperation and Development (OECD) guidelines. The acute oral toxicity study in Wistar rats suggests that the median lethal dose of CinDura® is at least 2000 mg/kg body weight. Acute dermal and eye irritation tests in New Zealand white rabbits indicate that the test item is nonirritant to the skin and eyes. A twenty-eight-day repeated dose oral toxicity study was conducted in male and female Wistar rats using daily doses of 250, 500, and 1000 mg/kg body weight, followed by a fourteen-day reversal period for two satellite groups. The CinDura®-supplemented animals did not show any sign of toxicity on their body weights, organ weights, and on the hematobiochemical parameters. The gross pathology and histopathological examinations indicated no treatment-related changes in the experimental animals. Overall, the no-observed-adverse-effect level (NOAEL) of the herbal blend is 1000 mg/kg body weight, the highest tested dose. Also, the results of the bacterial reverse mutation test and the erythrocyte micronucleus assay in mouse bone marrow suggest that CinDura® (GMCT) is neither mutagenic nor clastogenic.

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Hepatoprotective effect of α-mangostin against lipopolysaccharide/d-galactosamine-induced acute liver failure in mice

Cited by 32 publications

References 35 publications

Antioxidative activities of alpha-mangostin in high-fat/high-glucose diet and streptozotocin-induced insulin-resistant rodents

Antioxidative activities of alpha-mangostin in high-fat/high-glucose diet and streptozotocin-induced insulin-resistant rodents

Apolipoprotein A5 alleviates LPS/d-GalN-induced fulminant liver failure in mice by inhibiting TLR4-mediated NF-κB pathway

Acute, Subacute, and Genotoxicity Assessments of a Proprietary Blend of Garcinia mangostana Fruit Rind and Cinnamomum tamala Leaf Extracts (CinDura®)

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