Hepatoprotective effect of water bamboo shoot (<i>Zizania latifolia</i>) extracts against acute alcoholic liver injury in a mice model and screening of bioactive phytochemicals

Gao, Yuan; Zong, Zihao; Xia, Wei; Fang, Xiangjun; Liu, Ruiling; Wu, Wei; Mu, Honglei; Han, Yanchao; Xiao, Shaobo; Gao, Haiyan; Chen, Hangjun

doi:10.1002/fft2.217

Cited by 4 publications

(1 citation statement)

References 35 publications

(47 reference statements)

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“…These results indicated that different types of inulin and HDT water extract could activate the activities of ADH and ALDH to a certain extent, promote the metabolism of ethanol and acetaldehyde, and alleviate the injury caused by acute alcohol poisoning. This is consistent with the results of previous studies (Gao et al, 2023; Yang et al, 2023)…”

Section: Resultssupporting

confidence: 94%

Inulin alleviates acute alcoholism in mice by enhancing ethanol metabolism and regulating the intestinal flora

Bai,

Lan,

Luo

et al. 2024

eFood

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Inulin, a recognized prebiotic with diverse biological activities, has not yet been reported for its potential in treating alcoholism. Therefore, this study investigated the antialcoholic effects of short, long, and phosphorylated long‐chain inulin and the possible mechanisms. An acute alcoholic intoxication mice model was established, with the water extract of Hovenia dulcis Thunb serving as a positive control. The different inulins were used for intervention, and the drunkenness of the mice was observed by an animal behavior experiment. The serum liver function indexes (TP, ALB, GLB, ALT, and ALP), as well as the activity of ethanol metabolizing enzymes (ADH and ALDH) in the liver were measured, and the changes in intestinal flora were analyzed. The results showed that short‐chain inulin could alleviate acute alcoholism by activating ethanol metabolizing enzyme activity and improving intestinal flora, and it had a potential protective effect on acute alcoholic liver injury in mice.

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Section: Resultssupporting

confidence: 94%

Inulin alleviates acute alcoholism in mice by enhancing ethanol metabolism and regulating the intestinal flora

Bai,

Lan,

Luo

et al. 2024

eFood

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Schaftoside from Plumula nelumbinis mitigates “Shanghuo” by inhibiting low‐grade inflammation, diminishing oxidative stress, and enhancing energy metabolism

Li,

Wu,

Liu

et al. 2024

Food Frontiers

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The study was focused on the therapeutic potential of schaftoside (SS), a key bioactive compound found in Plumula nelumbinis, in the context of “Shanghuo,” an excessive internal heat condition induced by the overconsumption of capsaicin. “Shanghuo” in traditional Chinese medicine is characterized by symptoms like skin and mucous membrane redness, swelling, fever, and discomfort. It is commonly used to describe symptoms such as intense thirst, constipation, and a rapid or surging pulse. In modern medicine, it is associated with various factors, including dietary irritants, stress, gut microbiota imbalances, and immunological issues. The concept of Yin–Yang balance is pivotal in the theory of traditional Chinese medicine. Yin embodies elements of stability and inhibition, whereas Yang is indicative of vitality and assertiveness. Excessive capsaicin intake can also trigger “Shanghuo” symptoms by disrupting the body's balance of “Yin and Yang.” In the present study, we isolated SS from P. nelumbinis and performed in vitro antioxidant assays. SS exhibited a concentration‐dependent increase in antioxidant activity, indicating its potential to combat oxidative stress. In animal experiments, rats exposed to a high dose of capsaicin showed elevated levels of inflammatory markers and reduced antioxidant levels. SS effectively mitigated these imbalances, restored antioxidant enzyme activity, and reduced inflammation. Furthermore, capsaicin‐treated rats showed decreased energy metabolism and altered gut microbiota. SS treatment enhanced energy metabolism and increased the abundance of intestinal flora, highlighting its potential to restore metabolic balance. In conclusion, SS from P. nelumbinis shows promise in alleviating “Shanghuo” induced by excessive capsaicin intake.

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Comparison of different drying technologies for walnut (Juglans regia L.) pellicles: Changes from phenolic composition, antioxidant activity to potential application

Qingyang,

Ruohui,

Shiman

et al. 2023

Food Chemistry: X

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Hepatoprotective effect of water bamboo shoot (Zizania latifolia) extracts against acute alcoholic liver injury in a mice model and screening of bioactive phytochemicals

Cited by 4 publications

References 35 publications

Inulin alleviates acute alcoholism in mice by enhancing ethanol metabolism and regulating the intestinal flora

Inulin alleviates acute alcoholism in mice by enhancing ethanol metabolism and regulating the intestinal flora

Schaftoside from Plumula nelumbinis mitigates “Shanghuo” by inhibiting low‐grade inflammation, diminishing oxidative stress, and enhancing energy metabolism

Comparison of different drying technologies for walnut (Juglans regia L.) pellicles: Changes from phenolic composition, antioxidant activity to potential application

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