Hepatoprotective effect of the ethanol extract of Vitis thunbergii on carbon tetrachloride-induced acute hepatotoxicity in rats through anti-oxidative activities

Deng, Jeng Shyan; Chang, Yu Han; Wen, Chi Luan; Liao, Jung Chun; Hou, Wen Chi; Amagaya, Sakae; Huang, Szu-Wei; Huang, Guan Jhong

doi:10.1016/j.jep.2012.06.003

Cited by 43 publications

(28 citation statements)

References 34 publications

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“…The liver damage caused by CCl 4 is characterized by inflammation in early stage. In the damaged hepatocytes, CCl 4 is metabolized by cytochrome P450 into trichloromethyl radical, a highly reactive species that triggers lipid peroxidation and lead to hepatotoxicity (Deng et al, 2012). The toxic effects of CCl 4 reported herein were similar to those reported in the literature.…”

Section: Disscustionsupporting

confidence: 82%

Modulation of hepatotoxicity, DNA fragmentation and gene expression of Solanum nigrum leaves extract in rats treated with silver nanoparticles

2017

J App Pharma Sci

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The current study aimed to determine the antioxidant compounds in Solanum nigrum (S. nigrum) leaves extract, to synthesize silver nanoparticles (AgNPs) and to evaluate the protective role of the extract against the hepatotoxicity and genotoxicity of AgNPs compared to CCl4 in rats. Eight groups of female Sprague-Dawley rats were treated orally for 3 weeks included the control group, CCl4-trared group (0.1 ml/kg b.w twice a week), AgNPs-treated group (50 mg/kg b.w/day), AgNPs plus CCl4-treated group, S. nigrum leaves extract-treated group (0.5 mg/kg b.w) and the groups treated with AgNPs and/or CCl4 plus the extract. The results indicated that the extract was rich in the total phenolic, flavoniods and β-carotene. The size of synthesized AgNPs was 30-50 nm. Administration of AgNPs and/or CCl4 resulted in severe hepatotoxicity and histological changes, increased DNA fragmentation and down regulation of antioxidant gene expression in liver. The extract was safe and succeeded to mitigate the hazards effect of AgNPs and/or CCl4. It could be concluded that AgNPs have toxic effects and caution should be taken when they use in food or medical application. S. nigrum extract succeeded to protect the liver due to its higher content of antioxidant compounds.

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Section: Disscustionsupporting

confidence: 82%

Modulation of hepatotoxicity, DNA fragmentation and gene expression of Solanum nigrum leaves extract in rats treated with silver nanoparticles

2017

J App Pharma Sci

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“…Meanwhile, they can also resist or block the cell injury caused by oxygen free radicals and repair the injured cells. However, SOD and GSH may limit the effect of the anti-tumor medicine (Deng et al, 2012;Kohsaka et al, 2013). This study showed that BITC can reduce SOD activity and GSH expression, which is conductive for strengthening the anti-tumor activity.…”

Section: Discussionmentioning

confidence: 72%

Inhibitory Effect of Benzyl Isothiocyanate on Proliferation in vitro of Human Glioma Cells

Zhu¹,

Zhuang²,

Wang³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…The active components were reported to be resveratrol, resveratrol oligomers, 14−16 and other polyphenols. 17,18 Moreover, the ethanolic extract of VTT has exhibited less lipid accumulation through regulation of the AMPK-ACC pathway in hypercholesterolemic rabbits. 19 Therefore, the purpose of this study was to investigate whether VTT could decrease lipid levels to improve glucose tolerances in diet-induced obese rats.…”

Section: ■ Introductionmentioning

confidence: 99%

Anti-α-glucosidase and Anti-dipeptidyl Peptidase-IV Activities of Extracts and Purified Compounds from Vitis thunbergii var. taiwaniana

Lin

Chen

et al. 2015

J. Agric. Food Chem.

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Ethanol extracts (Et) from the stem (S) and leaf (L) of Vitis thunbergii var. taiwaniana (VTT) were used to investigate yeast α-glucosidase and porcine kidney dipeptidyl peptidase-IV (DPP-IV) inhibitory activities. Both VTT-Et showed complete α-glucosidase inhibition at 0.1 mg/mL; VTT-S-Et and VTT-L-Et showed 26 and 11% DPP-IV inhibition, respectively, at 0.5 mg/mL. The VTT-Et interventions (20 and 50 mg/kg) resulted in improvements in impaired glucose tolerance of diet-induced obese rats. (+)-Hopeaphenol, (+)-vitisin A, and (-)-vitisin B were isolated from the ethyl acetate fractions of S-Et and showed yeast α-glucosidase inhibition (IC50 = 18.30, 1.22, and 1.02 μM) and porcine kidney DPP-IV inhibition (IC50 = 401, 90.75, and 15.3 μM) compared to acarbose (6.39 mM) and sitagliptin (47.35 nM), respectively. Both (+)-vitisin A and (-)-vitisin B showed mixed noncompetitive inhibition against yeast α-glucosidase and porcine kidney DPP-IV, respectively. These results proposed that VTT extracts might through inhibitions against α-glucosidase and DPP-IV improve the impaired glucose tolerance in diet-induced obese rats.

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Hepatoprotective effect of the ethanol extract of Vitis thunbergii on carbon tetrachloride-induced acute hepatotoxicity in rats through anti-oxidative activities

Cited by 43 publications

References 34 publications

Modulation of hepatotoxicity, DNA fragmentation and gene expression of Solanum nigrum leaves extract in rats treated with silver nanoparticles

Modulation of hepatotoxicity, DNA fragmentation and gene expression of Solanum nigrum leaves extract in rats treated with silver nanoparticles

Inhibitory Effect of Benzyl Isothiocyanate on Proliferation in vitro of Human Glioma Cells

Anti-α-glucosidase and Anti-dipeptidyl Peptidase-IV Activities of Extracts and Purified Compounds from Vitis thunbergii var. taiwaniana

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