Hepatoprotective Effect of Syringic Acid and Vanillic Acid on CCl4-Induced Liver Injury

Itoh, Ayano; Isoda, Katsuhiro; Kondoh, Masuo; Kawase, Masaya; Watari, Akihiro; Kobayashi, Masakazu; Tamesada, Makoto; Yagi, Kiyohito

doi:10.1248/bpb.33.983

Cited by 186 publications

(103 citation statements)

References 18 publications

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“…All the glycosides were nontoxic in the hepatotoxicity analysis. The result of 2 was in accordance with the hepatoprotective effect on liver injury [14][15][16].…”

Section: Hepatotoxicity Assaysupporting

confidence: 70%

A new hepatotoxic triterpenoid ketone from Curculigo orchioides

Jiao¹,

Chen²,

Wang³

et al. 2013

Fitoterapia

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“…All the glycosides were nontoxic in the hepatotoxicity analysis. The result of 2 was in accordance with the hepatoprotective effect on liver injury [14][15][16].…”

Section: Hepatotoxicity Assaysupporting

confidence: 70%

A new hepatotoxic triterpenoid ketone from Curculigo orchioides

Jiao¹,

Chen²,

Wang³

et al. 2013

Fitoterapia

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“…Moreover, it was shown that vanillic acid scavenges the stable radical species, DPPH, in a dose-dependent manner, with the highest scavenging effects seen with 60 μM of vanillic acid (50). Due to the antioxidant activity of vanillic acid, like the hydroxycinnamic acids above it has protective capabilities, such as hepatoprotective effects, against several diseases which are associated with oxidative deterioration (50)(51)(52). Furthermore, vanillic acid might suppress fibrogenesis and inflammation in chronically injured livers (51,52).…”

Section: Hydroxybenzoic Acids From Lignin Hydrolysismentioning

confidence: 99%

Biological activities of lignin hydrolysate-related compounds

Lee¹,

Monnappa²,

Mitchell³

2012

BMB Reports

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“…o-Hydroxybenzoic acid (salicylic acid) has antiinflammatory, antiseptic, antifungal, antipyretic, analgesic and keratolitic properties (Lin and Nakatsui 1998). Vanillic acid (monomethoxy-derivative of phydroxybenzoic acid) exhibits antisickling and anthelmintic, as well as hepatoprotective, activities (Itoh et al 2009(Itoh et al , 2010. Syringic acid (dimethoxy-derivative of p-hydroxybenzoic acid), besides being an antioxidant, shows antibacterial and hepatoprotective activities (Itoh et al 2009(Itoh et al , 2010Kong et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Production of biologically active phenolic acids in Aronia melanocarpa (Michx.) Elliott in vitro cultures cultivated on different variants of the Murashige and Skoog medium

Szopa

2013

Plant Growth Regul

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Phenolic acids, both benzoic and cinnamic acid derivatives, are plant metabolites with high therapeutic and cosmetic values. Methanolic extracts from the biomass of shoot and callus cultures of Aronia melanocarpa growing on seven variants of the Murashige and Skoog (MS) medium with different concentrations of plant growth regulators, BA and NAA, ranging from 0.1 to 3.0 mg l -1 , were examined for the production of free phenolic acids and cinnamic acid using the high-performance liquid chromatography (HPLC) method. The extracts from the shoot and callus cultures were confirmed to contain five of the twelve compounds tested for: caffeic, p-coumaric, p-hydroxybenzoic, syringic and vanillic acids. The shoot extracts contained additionally salicylic acid. Both the total amounts and the amounts of individual compounds in either the shoot or callus extracts were dependent on the concentration of cytokinin and auxin in the MS medium variants. The total amounts in the shoot and callus cultures were in the range from 93.52 to 217.00 mg 100 g -1 DW and from 47.11 to 83.83 mg 100 g -1 DW, respectively. The amounts of individual compounds showed wide variation, from 1.31 to 91.86 mg 100 g -1 DW in the shoot extracts, and from 2.58 to 40.16 mg 100 g -1 DW in the callus extracts. Salicylic acid (max. 91.86 mg 100 g -1 DW), p-coumaric acid (max. 62.39 mg 100 g -1 DW) and p-hydroxybenzoic acid (max. 50.66 mg 100 g -1 DW) dominated in the shoot extracts, while syringic acid (max. 40.16 mg 100 g -1 DW) and p-hydroxybenzoic acid (max. 23.59 mg 100 g -1 DW) were the main metabolites in the callus extracts. This is the first report on the quantitative analysis of benzoic and cinnamic acid derivatives in shoot and callus cultures of A. melanocarpa growing on MS-based media with different concentrations of selected plant growth regulators-BA and NAA. The obtained maximum amounts of some metabolites are of interest from a practical perspective.

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Hepatoprotective Effect of Syringic Acid and Vanillic Acid on CCl4-Induced Liver Injury

Cited by 186 publications

References 18 publications

A new hepatotoxic triterpenoid ketone from Curculigo orchioides

A new hepatotoxic triterpenoid ketone from Curculigo orchioides

Biological activities of lignin hydrolysate-related compounds

Production of biologically active phenolic acids in Aronia melanocarpa (Michx.) Elliott in vitro cultures cultivated on different variants of the Murashige and Skoog medium

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