Hepatoprotective effect of Raspberry ketone and white tea against acrylamide-induced toxicity in rats

Hamdy, Soha M.; El-Khayat, Zakaria; Farrag, Abdel Razik H.; Sayed, Ola N.; El-Sayed, Mervat M; Massoud, Diaa

doi:10.1080/01480545.2020.1772279

Cited by 20 publications

(16 citation statements)

References 98 publications

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“…As mentioned above, Hamdy et al [63] confirmed that RK improves the SOD and CAT levels reduced by AA. In addition, RK treatment significantly decreased the plasma MDA level (Group IV, 13.18 ± 2.618 nmol/mL), which is increased by AA (Group II, 20.83 ± 1.83 nmol/mL).…”

Section: Lipid Peroxidationmentioning

confidence: 70%

“…Hamdy et al [63] conducted a study to evaluate the hepatoprotective effect of raspberry ketones on the oxidative stress induced by acrylamide (AA) in rats. In this experiment, rats were allocated randomly into four groups: Group I (control group); Group II (toxicity induced by AA (5 mg/kg/day)); Group III (treated with RK alone (6 mg/kg/day)); Group IV (treated with both AA and RK).…”

Section: Antioxidant Enzyme Activitymentioning

confidence: 99%

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Potentials of Raspberry Ketone as a Natural Antioxidant

Lim

Choi

2021

Antioxidants

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Oxidative stress is closely linked to various diseases, and many studies have been conducted to determine how to reduce this stress. In particular, efforts are being made to find potential antioxidants from natural products. Studies have shown that raspberry ketone (RK; 4-(4-hydroxyphenyl)-2-butanone) has various pharmacological activities. This review summarizes the antioxidant activities of RK and their underlying mechanisms. In several experimental models, it was proven that RK exhibits antioxidant properties through increasing total antioxidant capacity (TAC); upregulating antioxidant enzymes, such as superoxide dismutase (SOD) and catalase (CAT); and improving lipid peroxidation. In conclusion, research about RK’s antioxidant activities is directly or indirectly related to its other various physiological activities. Further studies at the clinical level will be able to verify the value of RK as an effective antioxidant, functional health food, and therapeutic agent.

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Section: Lipid Peroxidationmentioning

confidence: 70%

Section: Antioxidant Enzyme Activitymentioning

confidence: 99%

Potentials of Raspberry Ketone as a Natural Antioxidant

Lim

Choi

2021

Antioxidants

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“…The combination treatment of RK and white tea, after acrylamide-induced liver damage, showed a decrease in elevated liver enzymes such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP). Immuno-histological examination of rat livers showed a reduction in hepatic damage, measured as a decrease in necrotic changes and reduced inflammation and vacuolation [ 24 ].…”

Section: Potential Role Of Rk As a Hepatoprotectionmentioning

confidence: 99%

“…Raspberry ketone and white tea treatment also led to increased adiponectin levels and a decrease in caspase-3, an apoptosis marker level. Histopathological studies showed concurrent improvement in hepatic cell structure and function [ 24 ]. The CCL4-induced liver toxicity could be similarly reversed by RK treatment, thus strengthening the evidence for RK to be considered as a possible treatment for acute and chronic liver diseases.…”

Section: Potential Role Of Rk As a Hepatoprotectionmentioning

confidence: 99%

Pharmacological Exploration of Phenolic Compound: Raspberry Ketone—Update 2020

Rao

Kurakula

Mamidipalli³

et al. 2021

Plants

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Raspberry ketone (RK) is an aromatic phenolic compound naturally occurring in red raspberries, kiwifruit, peaches, and apples and reported for its potential therapeutic and nutraceutical properties. Studies in cells and rodents have suggested an important role for RK in hepatic/cardio/gastric protection and as an anti-hyperlipidemic, anti-obesity, depigmentation, and sexual maturation agent. Raspberry ketone-mediated activation of peroxisome proliferator-activated receptor-α (PPAR-α) stands out as one of its main modes of action. Although rodent studies have demonstrated the efficacious effects of RK, its mechanism remains largely unknown. In spite of a lack of reliable human research, RK is marketed as a health supplement, at very high doses. In this review, we provide a compilation of scientific research that has been conducted so far, assessing the therapeutic properties of RK in several disease conditions as well as inspiring future research before RK can be considered safe and efficacious with limited side effects as an alternative to modern medicines in the treatment of major lifestyle-based diseases.

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“…In addition, raspberry ketone is utilized as an attractant in insect baits (Perez 1983;Metcalf et al 1983;Deifel 1989) and as a component in perfumes (Dumont et al 1996;Farwick et al 2019), whereas further applications in cosmetic industry, e.g., as skin whitening or hair growth inducing agent, remain controversial (Harada et al 2008;Kim et al 2016). Other publications promote dose-dependent health benefits with regard to an anti-obese effect (Morimoto et al 2005;Park 2015;Tsai et al 2017;Zhao et al 2019;Mir et al 2019) or suggest medical applications due to its antioxidant and anti-inflammatory potential (Parmar and Tripathi 1991;Khan et al 2018;Fouad et al 2019;Mohamed et al 2020;Hamdy et al 2020).…”

Section: Introductionmentioning

confidence: 99%

An ADH toolbox for raspberry ketone production from natural resources via a biocatalytic cascade

Becker

Böttcher

Katzer³

et al. 2021

Appl Microbiol Biotechnol

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Raspberry ketone is a widely used flavor compound in food and cosmetic industry. Several processes for its biocatalytic production have already been described, but either with the use of genetically modified organisms (GMOs) or incomplete conversion of the variety of precursors that are available in nature. Such natural precursors are rhododendrol glycosides with different proportions of (R)- and (S)-rhododendrol depending on the origin. After hydrolysis of these rhododendrol glycosides, the formed rhododendrol enantiomers have to be oxidized to obtain the final product raspberry ketone. To be able to achieve a high conversion with different starting material, we assembled an alcohol dehydrogenase toolbox that can be accessed depending on the optical purity of the intermediate rhododendrol. This is demonstrated by converting racemic rhododendrol using a combination of (R)- and (S)-selective alcohol dehydrogenases together with a universal cofactor recycling system. Furthermore, we conducted a biocatalytic cascade reaction starting from naturally derived rhododendrol glycosides by the use of a glucosidase and an alcohol dehydrogenase to produce raspberry ketone in high yield. Key points • LB-ADH, LK-ADH and LS-ADH oxidize (R)-rhododendrol • RR-ADH and ADH1E oxidize (S)-rhododendrol • Raspberry ketone production via glucosidase and alcohol dehydrogenases from a toolbox Graphical abstract

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Hepatoprotective effect of Raspberry ketone and white tea against acrylamide-induced toxicity in rats

Cited by 20 publications

References 98 publications

Potentials of Raspberry Ketone as a Natural Antioxidant

Potentials of Raspberry Ketone as a Natural Antioxidant

Pharmacological Exploration of Phenolic Compound: Raspberry Ketone—Update 2020

An ADH toolbox for raspberry ketone production from natural resources via a biocatalytic cascade

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