Hepatoprotective effect of Opuntia microdasys (Lehm.) Pfeiff flowers against diabetes type II induced in rats

Chahdoura, Hassiba; Adouni, Khawla; Khlifi, Aida; Dridi, Ichrak; Haouas, Zohra; Neffati, Fadoua; Flamini, Guido; Mosbah, Habib; Achour, Lotfi

doi:10.1016/j.biopha.2017.07.093

Cited by 26 publications

(15 citation statements)

References 41 publications

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“…Lithium salts cause ocular side effects: polydipsia, polyuria, and diabetes insipidus. Oxidative stress has been proposed as an alternative mechanism of lithium toxicity in certain animal tissues, via impairment of mitochondrial respiratory system that leads to increased generation of free radicals through lipid peroxidation of cell membrane [ 3 – 6 ]. Since free radical generation is expected to induce organ toxicities including nephrocardiotoxicity, supplementation with antioxidants may improve tissue capacity to cope with the high antioxidant demands [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Ameliorative Effect of Cactus(Opuntia ficus indica)Extract on Lithium-Induced Nephrocardiotoxicity: A Biochemical and Histopathological Study

Saad

Rjeibi

Ncib

et al. 2017

BioMed Research International

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Opuntia ficus indica (family Cactaceae) is used in the treatment of a variety of conditions including metal-induced toxicity. The study reports the protective effects of Opuntia ficus indica (CCE) against lithium carbonate-induced toxicity in rats. Nephrocardiotoxicity was induced in male Wistar rats by single dose of lithium carbonate (25 mg/kg b.w twice daily for 30 days). Aqueous extract of Opuntia ficus indica was administered at the dose of 100 mg/kg of b.w by gavage for 60 days. Obtained results revealed that administration of lithium carbonate caused a significant increase in serum creatinine, uric acid, and urea levels. Additionally, a significant decrease in the level of renal and cardiac SOD, CAT, and GPx activities was associated with a significant increase of MDA levels in lithium carbonate group more than those of the control. However, the treatment of experimental rats with CCE prevented these alterations and maintained the antioxidant status. The histopathological observations supported the biochemical evidences of nephrocardioprotection. CCE supplementation could protect against lithium carbonate-induced renal and cardiac injuries in rats, plausibly by the upregulation of antioxidant enzymes and inhibition of MDA to confer the protective effect.

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Section: Introductionmentioning

confidence: 99%

Ameliorative Effect of Cactus(Opuntia ficus indica)Extract on Lithium-Induced Nephrocardiotoxicity: A Biochemical and Histopathological Study

Saad

Rjeibi

Ncib

et al. 2017

BioMed Research International

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“…El‐Hadary and Ramadan (, ) reported that cold‐pressed oils showed protective effects against carbon tetrachloride‐induced hepatotoxicity in rats. Chahdoura et al () investigated the hepatoprotective impacts of Opuntia microdasys flowers against induced type 2 diabetes in rats. O. microdasys exhibited hepatoprotective effects and reduced some of the diabetes causes.…”

Section: Discussionmentioning

confidence: 99%

“…The participation of aromatic plants and herbs is enormous to disease prevention (Adam et al, 2016;Almuaigel, Seif, Albuali, Alharbi, & Alhawash, 2017;Assiri, Elbanna, Abulreesh, & Ramadan, 2016;Chahdoura et al, 2017;Rahimi-Madiseh et al, 2017). According to WHO, more than 150 herbs and plants are utilized to treat DM (Hebi, Farid, Ajebli, & Eddouks, 2017).…”

Section: Introductionmentioning

confidence: 99%

Ameliorative impact of cold‐pressedRosmarinus officinalisoil against liver toxicity and genotoxic effects in streptozotocin‐induced diabetic rats and their offspring

et al. 2019

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Diabetes mellitus (DM) is a chronic, lifelong condition threatening human health. Rosmarinus officinalis oil (RO) could have a future role in DM therapy. This study evaluated the composition and antioxidative potential of RO. Antidiabetic traits of RO in streptozotocin (STZ)‐induced diabetic rats was also studied considering the ameliorative impact against embryogenesis defects using in vitro and in vivo biochemical, histological, and genetic assays. RO was investigated for fatty acids and bioactive compounds (tocols and total phenolic compounds), and antiradical potential against DPPH• radicals. The genetic effects were investigated using comet assay and DNA fragmentation test. DM was induced to albino rats by injecting 60 mg/kg of STZ, while RO (100 mg/kg b.w.) was administered. The pregnant animals were divided into four groups; control (C), RO‐treated (RO), diabetic (D), and combined diabetic with RO‐treated (D‐RO). The study was conducted for 180 days. In RO, the contents of polyunsaturated fatty acids, monounsaturated fatty acids, and saturated fatty acids were 42.3%, 41.7%, and 15.8%, respectively. The levels of α‐, β‐, γ‐, and δ‐tocopherols were 280, 20, 1,025, and 35 mg/100 g RO, respectively. RO contained 7.2 mg GAE/g of total phenolic compounds (TPC), while RO quenched 70% of DPPH• radicals. While glucose levels reached the highest in DM rats, treating STZ‐induced diabetic animals with RO‐resoluted serum glucose levels. RO reduced the highest levels of serum chemistry parameters were recorded in DM animals. Histological photographs of maternal and fetus liver exhibited degenerated hepatic cells and congestion central vein. Comet cells and DNA fragments were significantly decreased in D‐RO group comparing to the DM group. RO exhibited antidiabetic capabilities, and thus, it could be utilized as a functional ingredient in novel foods, nutraceuticals, and dietary supplements for diabetic patients. Practical applications RO is rich in bioactive phytochemicals (tocols and phenolic compounds) with antiradical and antihyperglycemic capabilities. Tocols and phenolics are active in radical scavenging of reactive nitrogen species (i.e., peroxynitrite and nitrogen dioxide), and in the prevention of DNA bases nitration. Our results demonstrated that RO could improve the disturbed metabolism of carbohydrate in STZ‐diabetic animals. The potential mode of action of bioactive compounds in RO most likely encompasses the intracellular pathway involved in glucose homeostasis or insulin signaling. In addition, the suppression of oxidative stress by phenolic compounds could provide to the antidiabetic impacts of RO. Our data supported that RO could be utilized to ameliorate DM. Protection with RO directed high protection of the maternal organs and offspring against the oxidative stress of diabetes due to the antihyperlipidemic effects and the antioxidant capabilities of RO.

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“…Pancreas and liver tissues were collected, washed and stored in NBS (10%, v/v) for fixation [19]. Tissues were embedded in paraffin, sectioned (5µm) and H&E staining was performed.…”

Section: Histopathological Examinationmentioning

confidence: 99%

Influence of Ocimum sanctum (L.) Extract on the Activity of Gliclazide in Alloxan-induced Diabetes in Rats

Ramzan¹,

Aslam²,

Muhammad³

et al. 2020

Rev. Chim.

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Ocimum sanctum L. is widely used as traditional remedy to manage hyperglycemia. This study was aimed to evaluate the effect of aqueous-methanolic extract of O. sanctum leaves (OSE) on the anti-diabetic activity of gliclazide in alloxan-induced diabetes in Wistar rats. Diabetes was induced by intraperitoneally injecting alloxan (120 mg/kg b.w.) in rats. Treatments including OSE (100 mg/kg b.w.), gliclazide (100 mg/kg b.w.), and in combination were given daily to diabetic rats till the 21st day of study. Body weight and fasting blood glucose levels were determined at regular intervals, while blood and organ samples were taken at the end of the study for biochemical and histopathological studies. Results showed that treatments exhibited anti-hyperglycemic activity through significantly (p [ 0.05) restoring body weight, fasting blood glucose level, and serum levels of glucose, insulin and HbA1c. The anti-lipidemic activity was noticed as total cholesterol (TC), triglyceride (TG), high-/low density-lipoproteins (HDL-C, LDL-C) levels were restored in treated diabetic rats. Ameliorative effects of treatments were observed as significant (p [ 0.05) reduction in serum levels of liver function biomarkers (alanine aminotransferase; ALT, aspartate aminotransferase; AST, alkaline phosphatase; ALP and bilirubin; BIL) and restoration of oxidative stress biomarkers (catalase; CAT, superoxide dismutase; SOD and malondialdehyde; MDA) in liver tissue. Histopathological findings supported these results as an increase in pancreatic islets size and protective effects on liver tissue was observed in diabetic rats treated with gliclazide and OSE alone and their combination. Conclusively, the combination of OSE and gliclazide produced a synergistic anti-diabetic effect as compared to that of alone treatment.

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Hepatoprotective effect of Opuntia microdasys (Lehm.) Pfeiff flowers against diabetes type II induced in rats

Cited by 26 publications

References 41 publications

Ameliorative Effect of Cactus(Opuntia ficus indica)Extract on Lithium-Induced Nephrocardiotoxicity: A Biochemical and Histopathological Study

Ameliorative Effect of Cactus(Opuntia ficus indica)Extract on Lithium-Induced Nephrocardiotoxicity: A Biochemical and Histopathological Study

Ameliorative impact of cold‐pressedRosmarinus officinalisoil against liver toxicity and genotoxic effects in streptozotocin‐induced diabetic rats and their offspring

Influence of Ocimum sanctum (L.) Extract on the Activity of Gliclazide in Alloxan-induced Diabetes in Rats

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