Hepatoprotective Effect Of &lt;i&gt;Cymbopogon Citratus&lt;/i&gt; Aqueous Extract Against Hydrogen Peroxide-Induced Liver Injury In Male Rats

Rahim, Saleh M.; Taha, Ekhlass M.; Al-janabi, Muneef Saeb; Al-douri, Bushra Ismael; Das, Simon Kumar; Mazlan, A.G.

doi:10.4314/ajtcam.v11i2.31

Cited by 26 publications

(12 citation statements)

References 31 publications

(18 reference statements)

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“…These studies consisted of inducing liver damages and monitoring hepatic enzymes after administration of the plant extract. The agents used to induce the damages are often carbon tetrachloride (Diallo et al, 1987;Loki and Rajamohan, 2003;Ikewuchi et al, 2011;Osadebe et al, 2012;Sangare et al, 2012b;Baligar et al 2014), acetaminophen (Olaleye and Rocha, 2008), hydrogen peroxide (Rahim et al, 2014), cisplatin (Dkhil et al, 2013), the acetylaminoflouren (Adetutu and Olorunnisola, 2013) and the galactosamine or lipopolysaccharides (Bawankule et al, 2014). In the particular case of Ocimum canum, George and Chaturvedi (2008) used alcohol to induce oxidative stress in rats and followed the effect of the plant on the liver.…”

Section: Discussionmentioning

confidence: 96%

“…R.Br. ex G.Don Viral hepatitis A and C (Guinnin et al, 2015); liver damage Fever (Clement et al, 2015) Protective effect of the oil on DNA damage and carcinogenesis in female Balb/C mice (Bidinotto et al, 2011) ; Cardioprotective effect by biochemical and histopathological changes in experimentally induced cardiotoxicity (Gayathri et al, 2011) Hepatoprotective effect of the aqueous extract against hydrogen peroxide-induced liver injury in male rats (Rahim et al, 2014); alleviation of carbon tetrachloride-induced hepatic oxidative stress and toxicity (Koh et al, 2012) Morinda lucida Benth.…”

Section: Azadirachta Indica a Jussmentioning

confidence: 99%

See 1 more Smart Citation

An ethnobotanical study of plants used to treat liver diseases in the Maritime region of Togo

Kpodar

Karou

Katawa

et al. 2016

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 96%

Section: Azadirachta Indica a Jussmentioning

confidence: 99%

An ethnobotanical study of plants used to treat liver diseases in the Maritime region of Togo

Kpodar

Karou

Katawa

et al. 2016

Journal of Ethnopharmacology

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“…Indeed, there are numerous reports on the antioxidant activity of C. citratus as well as its potential to inhibit many drug/chemical-induced adverse health effects. For example, studies by Arhoghro et al, [25], Koh et al, [15], and Rahim et al [26] demonstrated the ameliorative effect of C. citratus leaf extracts on chemical-induced liver damage (by cisplatin, carbon tetrachloride, and hydrogen peroxide, respectively). Additionally, Gayathri et al, [27] have observed that C. citratus extract produces marked attenuation of isoprenoidinduced cardiotoxicity and lipid peroxidation in rats.…”

Section: Discussionmentioning

confidence: 99%

Lemongrass Leaf Extract Attenuates Hydrocarbon-Induced Oxidative Stress and Macrocytic Hypochromic Anaemia in Rats

Ekpenyong¹

2017

IJEE

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The therapeutic use of medicinal plants and plant products to mitigate solvent/xenobiotic-induced haematological disorders has not been adequately explored. The aim of this study was to evaluate the effect of Cymbopogon citratus (C. citratus) leaf decoctions on gasoline vapour (GV)-induced haematological disorders and oxidative stress in rats. Seventy-two female rats weighing 180-200g were randomly selected and divided into six groups (n = 12 per group). Animals in group 1 served as unexposed controls, while animals in group 2 were exposed to gasoline vapour (GV) alone for 35 days. Animals in groups 3, 4, and 5 were exposed to GV and co-administered C. citratus leaf extract (500 mg/kg, 1000 mg/kg, and 1500 mg/kg, respectively), and animals in group 6 were exposed to GV and co-administered vitamin C (200 mg/kg) for the same time period. Exposure of animals to GV alone significantly (p < 0.05) decreased packed cell volume (PCV), haemoglobin concentration (HB), total red blood cells (RBC), mean cell haemoglobin (MCH) and mean cell haemoglobin concentration (MCHC). Total white blood cells (WBC), WBC lineages and malondialdehyde (MDA) levels significantly increased (p < 0.05) compared to the corresponding values in the control group. Supplementation with C. citratus leaf decoction and vitamin C reversed these GV-induced changes in haematological indices and MDA levels. Therefore, C. citratus leaf decoctions and vitamin C supplementation provided an ameliorative effect on GV-induced haematotoxicity and oxidative stress in a rat model of gasoline exposure.

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“…Our study evaluated that supplementation of 1% Syzygium cumini seed increased SOD concentration even more than the control group. Another biological protecting enzyme, catalase [50] which generally breaks down H 2 O 2 into water and neutralize the harmful activity of hydrogen peroxide [51] found lower once acetaminophen toxic group was treated with 1% Syzygium cumini seed (Figure 3).…”

Section: Discussionmentioning

confidence: 99%

Fresh Seed Supplementation of Syzygium Cumini Attenuated Oxidative Stress, Inflammation, Fibrosis, Iron Overload, Hepatic Dysfunction and Renal Injury in Acetaminophen Induced Rats

Sagor¹,

Mohib²,

Tabassum³

et al. 2016

J Drug Metab Toxicol

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Nowadays, the drug induced organ damage has increased drastically. Similarly, number of Adverse Drug Reactions (ADR) is on the rise. Unwanted and harmful effects of a drug have been a good reason for early withdrawal of a good molecule from the market or clinical trial. In the present study, we have investigated the preventive role of Syzygium cumini against Acetaminophen induced organ damage. In this study, four different groups of rats were evaluated. Group A serves as a control group, Group B serves as control + Syzygium cumini group, Group C serves as disease group and Group D serves as disease + treatment group. Only two groups have been treated and exposed to an overdose of acetaminophen. However, liver and kidney markers like Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP), Alanine Transaminase (ALT), Creatinin and Uric acid (UA) were measured respectively. Moreover, oxidative stress markers such as Malondialdehyde (MDA), Nitric Oxide (NO) and Advanced Oxidation Protein Product (AOPP) were found higher in acetaminophen overdose rats compared to control rats. Furthermore, antioxidant enzymes like Catalase (CAT), Superoxide Dismutase (SOD) and Linear Peptide Glutathione (GSH) were restored significantly by Syzygium cumini seed treatment. Finally, our study revealed that supplementation of 1% Syzygium cumini seed with food attenuated inflammatory cell infiltration, collagen secretion, extracellular matrix deposition and iron overload in both hepatic and kidney. We assume that the protection might be achieved due to having strong antioxidant properties of Syzygium cumini.

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Hepatoprotective Effect Of <i>Cymbopogon Citratus</i> Aqueous Extract Against Hydrogen Peroxide-Induced Liver Injury In Male Rats

Cited by 26 publications

References 31 publications

An ethnobotanical study of plants used to treat liver diseases in the Maritime region of Togo

An ethnobotanical study of plants used to treat liver diseases in the Maritime region of Togo

Lemongrass Leaf Extract Attenuates Hydrocarbon-Induced Oxidative Stress and Macrocytic Hypochromic Anaemia in Rats

Fresh Seed Supplementation of Syzygium Cumini Attenuated Oxidative Stress, Inflammation, Fibrosis, Iron Overload, Hepatic Dysfunction and Renal Injury in Acetaminophen Induced Rats

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