Hepatoprotective Effect of &lt;i&gt;Adenema hyssopifolium G. Don&lt;/i&gt; (Gentianaceae) in Carbon Tetrachloride-Induced Hepatotoxicity in Rats

Rajasekaran, A.; Arivukkarasu, Ramasamy; Shivashankar, Murugesh

doi:10.4314/tjpr.v9i2.53703

Cited by 6 publications

(5 citation statements)

References 14 publications

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“…The present investigation indicates that the ethanolic extract of E. littorale exhibits significant hepatomodulation against oxidative stress induced liver injury by CCl 4 in rats through antioxidant potential and free radical scavenging activities along with reduction of fat metabolism [13] . These attributes provide the rationale for the use of E. littorale in liver disorders by traditional healers in India [32] .…”

Section: Hepatoprotective Activity Of E Littoralementioning

confidence: 99%

Pharmacognosy of Enicostemma littorale: A review

Saranya

Thirumalai²,

Hemalatha

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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Section: Hepatoprotective Activity Of E Littoralementioning

confidence: 99%

Pharmacognosy of Enicostemma littorale: A review

Saranya

Thirumalai²,

Hemalatha

et al. 2013

Asian Pacific Journal of Tropical Biomedicine

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“…15 In India, Enicostemma axillare is used by the traditional healers for the treatment of liver disorders, which we have scientifically validated in our earlier study in rats. 16 To ascertain and establish the safety for its use in traditional practice, acute and sub-acute toxicity studies of the aqueous extract of Enicostemma axillare were carried out as per OCED guidelines. …”

Section: Introductionmentioning

confidence: 99%

Acute and Sub-acute Toxicity Study of Aqueous Extracts of Enicostemma axillare (Lam.) Raynal in Animal models

Rajasekaran¹,

Arivukkarasu²

2015

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Background: Enicostemma axillare (Lam.) Raynal is used in traditional practice for the treatment of diabetes, malaria and liver disorders. No systematic toxicity study was described for this plant and hence the present was undertaken to evaluate acute and sub-acute toxicity of aqueous extract of Enicostemma axillare (AEEA). Objective: The acute oral toxicity study of AEEA was carried out as per the OECD guidelines 423 in mice and the sub-acute toxicity was carried out as per the guidelines set by OECD 407 in male and female rats. Materials and Methods: Body weight, food and water consumption, hematological parameters, biochemical parameters, organ weight and histopathological analysis were carried out. Results: No gross toxicity and mortality was observed upto a dose of 2000 mg/kg. For sub-acute toxicity test, 200 mg/kg and 400 mg/kg daily dose of AEEA administered orally for 28 days in male and female group of rats not exhibited any signs of toxicity and mortality.

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“…Paraffin sections (7 µm thick) of buffered formalin-fixed liver samples were stained with hematoxylineosin (which stains the nuclei blue and the cytoplasm pink) to study the liver histological structure of the control and treated rats. The sections were then observed under microscope for histopathological changes in liver architecture and their photomicrographs were taken 14,15 .…”

Section: Histopathological Studiesmentioning

confidence: 99%

“…The serum was used for estimation of biochemical parameters to determine the functional state of the liver 14,15 . Serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), alkaline phosphatase (ALP), Total bilirubin (TB) and Direct bilirubin (DL) were estimated 16 by Arba kit (Trans Asia bio medical ltd. Mumbai) and Autopak kit (Siemens health care diagnostic company, Baroda).…”

Section: Assessment Of Liver Functionmentioning

confidence: 99%

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Hepatoprotective Activity of Inula Cappa Dc. Aqueous Extract Against Carbon Tetrachloride Induced Hepatotoxicity in Wistar Rats

Kaur¹,

Kumar²,

Sharma³

2017

Int. Res. J. Pharm.

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Inula cappa is well known for its medicinal properties like anti-inflammatory, digestive, depurative, carminative, analgesics, antipyretics, treatment of peptic ulcer etc. The present study focuses on the ability of I. cappa to alleviate liver damage caused by over carbon tetrachloride. The aqueous extract of whole plant of I. cappa (400 mg/kg, p.o) significantly showed hepatoprotective activity followed by whole plant extract at dose of 200mg/kg body weight and least hepatoprotective effect was observed with stem extract. Histopathological liver sections also revealed that the normal liver architecture was disturb ed by hepatotoxin in carbon tetrachloride group, whereas the liver sections of the rat treated with the aqueous extract showed normal cellular architecture and is comparable with the standard silymarin treated group. Hence the aqueous extract of whole plant confirms hepatoprotective effect in carbon tetrachloride induced hepatotoxicity in rats.

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Hepatoprotective Effect of <i>Adenema hyssopifolium G. Don</i> (Gentianaceae) in Carbon Tetrachloride-Induced Hepatotoxicity in Rats

Cited by 6 publications

References 14 publications

Pharmacognosy of Enicostemma littorale: A review

Pharmacognosy of Enicostemma littorale: A review

Acute and Sub-acute Toxicity Study of Aqueous Extracts of Enicostemma axillare (Lam.) Raynal in Animal models

Hepatoprotective Activity of Inula Cappa Dc. Aqueous Extract Against Carbon Tetrachloride Induced Hepatotoxicity in Wistar Rats

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