Hepatoprotective effect of <i>tempol</i> on oxidative toxic stress in STZ-induced diabetic rats

Ghadermazi, Rozhin; Khoshjou, Farhad; Zijoud, S M Hossini; Behrooj, Hamid; Kheiripour, Nejat; Ganji, Maziar; Moridi, Heresh; Mohammadi, Mojdeh; Ranjbar, Akram

doi:10.1080/15569543.2017.1313277

Cited by 18 publications

(6 citation statements)

References 30 publications

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“…Alanine aminotransferase and AST were considered important indexes, indicating hepatocellular injuries (49). Sometimes liver is injured or damaged, and ALT and AST are released into the circulation from the cytosol and subcellular organelles of hepatocytes and their activities increase in the blood (50).…”

Section: Discussionmentioning

confidence: 99%

L-carnitine Attenuates DNA Damage and Oxidative Stress in Diabetic Animals

Kanani

Etebari

2022

Int J Cancer Manag

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Background: Diabetes is a metabolic disorder characterized by high plasma glucose levels. In this disease, increased production of reactive oxygen species (ROS) results in DNA damage and multiple complications. L-carnitine (LC) has shown a potent antioxidant activity that may reduce oxidative stress. Objectives: This study aims at assaying the effect of LC on DNA damage in streptozotocin-induced diabetic rats and evaluating the changes in antioxidant markers and liver function enzymes after the administration of LC . Methods: In the present study, for induction of diabetes, we injected a single dose of streptozotocin (65 mg/kg) by the intraperitoneal route, and diabetic rats were treated with LC 200, 300, and 400 mg/kg daily for 3 weeks. We detected the DNA damage at 7, 14, and 21 days after induction diabetes by the comet assay method. The blood glucose level, plasma alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were tested. Also, we measured the activity levels of superoxide dismutase (SOD) and intracellular glutathione (GSH). Results: The results of this study demonstrated the increasing amount of DNA damage with the amount and duration of hyperglycemia. L-carnitine treatment significantly decreased the parameters of genotoxicity such as % DNA in the tail, tail length, and tail moment over time. Moreover, the treatment of diabetic rats with LC 300 and 400 mg/kg/day after 21 days led to a remarkable decrease in blood glucose than diabetic rats. Also, we observed that LC can ameliorate enzyme liver function and reduce oxidative stress via enhancement of GSH and SOD levels. Conclusions: The results of this study indicated the protective effect of LC against DNA damage and oxidative stress in diabetic rats.

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Section: Discussionmentioning

confidence: 99%

L-carnitine Attenuates DNA Damage and Oxidative Stress in Diabetic Animals

Kanani

Etebari

2022

Int J Cancer Manag

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“…DOI: http://doi.org/10.35652/IGJPS.2020.104011 . risk of degenerative diseases particularly cardiovascular diseases and cancer [5]. Among these, essential oils are a mixture of complex natural compounds of medicinal and aromatic plants comprising mostly of volatile constituents with characteristic aroma and are employed in drug, food and perfumery industries [6].…”

Section: Indo Global Journal Of Pharmaceutical Sciences Issn 2249-1023mentioning

confidence: 99%

Antioxidant and Antiglycation Potential of Essential Oil Extracts from Leaves and Stems of Erythroxylum monogynum Roxb.

Bindu¹,

Kiran²

2020

IGJPS

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“…The liver plays an important role in the synthesis of PON 1 which is able to hydrolyse a number of substrates, including phenyl acetate, paraoxon, lipid peroxides, cholesterol esters and hydroperoxides (Shokri et al 2020). Imbalance between the production of reactive oxygen species (ROS) and inadequate antioxidant defense systems can lead to oxidative toxic stress (OTS) and cell damage not only directly but also indirectly by changing signaling pathways (Ghadermazi et al 2018). ROS production results from endogenous factors such as elevation of mitochondrial dysfunction and oxidative enzymes in infections and inflammations and exogenous factors such as air pollution, radiation and drug exposures .…”

Section: Introductionmentioning

confidence: 99%

Untitled

2021

JJBS

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Instructions to AuthorsScopes Study areas include cell biology, genomics, microbiology, immunology, molecular biology, biochemistry, embryology, immunogenetics, cell and tissue culture, molecular ecology, genetic engineering and biological engineering, bioremediation and biodegradation, bioinformatics, biotechnology regulations, gene therapy, organismal biology, microbial and environmental biotechnology, marine sciences. The JJBS welcomes the submission of manuscript that meets the general criteria of significance and academic excellence. All articles published in JJBS are peerreviewed. Papers will be published approximately one to two months after acceptance.

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Hepatoprotective effect of tempol on oxidative toxic stress in STZ-induced diabetic rats

Cited by 18 publications

References 30 publications

L-carnitine Attenuates DNA Damage and Oxidative Stress in Diabetic Animals

L-carnitine Attenuates DNA Damage and Oxidative Stress in Diabetic Animals

Antioxidant and Antiglycation Potential of Essential Oil Extracts from Leaves and Stems of Erythroxylum monogynum Roxb.

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