Hepatoprotective effect of<i>Geranium schiedeanum</i>against ethanol toxicity during liver regeneration

Madrigal-Santillán, Eduardo; Bautista, Mirandeli; Gayosso-de-Lucio, Juan A.; Reyes-Rosales, Yadira; Posadas-Mondragón, Araceli; Morales-González, Ángel; Soriano-Ursúa, Marvin A.; García-Machorro, Jazmín; Álvarez-González, Isela; Morales-González, José A

doi:10.3748/wjg.v21.i25.7718

Cited by 21 publications

(13 citation statements)

References 46 publications

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“…This might have happened because the ethanol metabolism increased the NADH/NAD + ratio changing the redox state balance in hepatocytes (Zakhari 2006), which mobilizes fatty acids for accumulation instead oxidation, resulting on fatty liver condition that lead to impairments of others metabolic pathways increasing the serum triglycerides. Thus, beyond antioxidant property of coconut water, ascorbic and caff eic acid modulating positively triglycerides levels (Madrigal-Santillán et al 2015), impairment on glucose and lipid metabolism could be improved by glucose, ascorbic and caff eic acid present in coconut water, leading to reduction on triglyceride serum content (Braun et al 1996, Jung et al 2006). …”

Section: Resultsmentioning

confidence: 99%

Reduction of the DNA damages, Hepatoprotective Effect and Antioxidant Potential of the Coconut Water, ascorbic and Caffeic Acids in Oxidative Stress Mediated by Ethanol

Bispo

Dantas

Filho

et al. 2017

An. Acad. Bras. Ciênc.

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Hepatic disorders such as steatosis and alcoholic steatohepatitis are common diseases that affect thousands of people around the globe. This study aims to identify the main phenol compounds using a new HPLC-ESI + -MS/MS method, to evaluate some oxidative stress parameters and the hepatoprotective action of green dwarf coconut water, caffeic and ascorbic acids on the liver and serum of rats treated with ethanol.The results showed five polyphenols in the lyophilized coconut water spiked with standards: chlorogenic acid (0.18 µM), caffeic acid (1.1 µM), methyl caffeate (0.03 µM), quercetin (0.08 µM) and ferulic acid (0.02 µM) isomers. In the animals, the activity of the serum γ-glutamyltranspeptidase (γ-GT) was reduced to 1.8 I.U/L in the coconut water group, 3.6 I.U/L in the ascorbic acid group and 2.9 I.U/L in the caffeic acid groups, when compared with the ethanol group (5.1 I.U/L, p<0.05). Still in liver, the DNA analysis demonstrated a decrease of oxidized bases compared to ethanol group of 36.2% and 48.0% for pretreated and post treated coconut water group respectively, 42.5% for the caffeic acid group, and 34.5% for the ascorbic acid group. The ascorbic acid was efficient in inhibiting the thiobarbituric acid reactive substances (TBARS) in the liver by 16.5% in comparison with the ethanol group. These data indicate that the green dwarf coconut water, caffeic and ascorbic acids have antioxidant, hepatoprotective and reduced DNA damage properties, thus decreasing the oxidative stress induced by ethanol metabolism.

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Section: Resultsmentioning

confidence: 99%

Reduction of the DNA damages, Hepatoprotective Effect and Antioxidant Potential of the Coconut Water, ascorbic and Caffeic Acids in Oxidative Stress Mediated by Ethanol

Bispo

Dantas

Filho

et al. 2017

An. Acad. Bras. Ciênc.

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“…Studies also showed that Monolluma quadrangula (Forssk.) Plowes, Geranium schiedeanum Schltdl., and Phyllanthus emblica L. are also effective in this respect (Ibrahim et al, 2015;Madrigal-Santillán et al, 2015;Chaphalkar et al, 2017). Recently a number of reviews have been published on the topic (Guan et al, 2018;Singh et al, 2018).…”

Section: Preclinical and Clinical Research Based On Ethnopharmacologimentioning

confidence: 99%

Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook

et al. 2020

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Excessive alcohol consumption is the cause of several diseases and thus is of a major concern for society. Worldwide alcohol consumption has increased by many folds over the past decades. This urgently calls for intervention and relapse counteract measures. Modern pharmacological solutions induce complete alcohol self-restraint and prevent relapse, but they have many side effects. Natural products are most promising as they cause fewer adverse effects. Here we discuss in detail the medicinal plants used in various traditional/folklore medicine systems for targeting alcohol abuse. We also comprehensively describe preclinical and clinical studies done on some of these plants along with the possible mechanisms of action.

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“…The authors reported that liver regeneration was delayed after PH in the absence of Nrf-2, suggesting that the activation of this transcriptional factor could improve liver regeneration in patients with acute or chronic lesion. Madrigal-Santillán et al [ 31 ] reported the hepatoprotector effect of Geranium schiedeanum in the inhibition caused by ethanol after PH, suggesting that this protection is due both to the trapping effect of the free radicals possessed by G. schiedeanum and to the regulation of Nrf-2, concluding that Nrf-2 protects the regenerating liver from ethanol-related damage.…”

Section: Nrf-2 and Liver Regenerationmentioning

confidence: 99%

What is Known Regarding the Participation of Factor Nrf-2 in Liver Regeneration?

Morales-González

Madrigal-Santillán

Morales-González

et al. 2015

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It has been known for years that, after chemical damage or surgical removal of its tissue, the liver initiates a series of changes that, taken together, are known as regeneration, which are focused on the recovery of lost or affected tissue in terms of the anatomical or functional aspect. The Nuclear factor-erythroid 2-related factor (Nrf-2) is a reduction-oxidation reaction (redox)-sensitive transcriptional factor, with the basic leucine Zipper domain (bZIP) motif, encoding the NFE2L2 gene. The Keap1-Nrf2-ARE pathway is transcendental in the regulation of various cellular processes, such as antioxidant defenses, redox equilibrium, the inflammatory process, the apoptotic processes, intermediate metabolism, detoxification, and cellular proliferation. Some reports have demonstrated the regulator role of Nrf-2 in the cellular cycle of the hepatocyte, as well as in the modulation of the antioxidant response and of apoptotic processes during liver regeneration. It has been reported that there is a delay in liver regeneration after Partial hepatectomy (PH) in the absence of Nrf-2, and similarly as a regulator of hepatic cytoprotection due to diverse chemical or biological agents, and in diseases such as hepatitis, fibrosis, cirrhosis, and liver cancer. This regulator/protector capacity is due to the modulation of the Antioxidant response elements (ARE). It is postulated that oxidative stress (OS) can participate in the initial stages of liver regeneration and that Nrf-2 can probably participate. Studies are lacking on the different initiation stages, maintenance, and the termination of liver regeneration alone or with ethanol.

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Hepatoprotective effect ofGeranium schiedeanumagainst ethanol toxicity during liver regeneration

Abstract: The administered extract showed a hepatoprotective effect, limiting the EtOH-induced hepatotoxic effects. This effect can be related to modulating oxido-reduction processes.

Cited by 21 publications

References 46 publications

Reduction of the DNA damages, Hepatoprotective Effect and Antioxidant Potential of the Coconut Water, ascorbic and Caffeic Acids in Oxidative Stress Mediated by Ethanol

Reduction of the DNA damages, Hepatoprotective Effect and Antioxidant Potential of the Coconut Water, ascorbic and Caffeic Acids in Oxidative Stress Mediated by Ethanol

Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook

What is Known Regarding the Participation of Factor Nrf-2 in Liver Regeneration?

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