Hepatoprotective effect of<i>Amomum xanthoides</i>against dimethylnitrosamine-induced sub-chronic liver injury in a rat model

Wang, Jinghua; Wang, Jian; Choi, Min‐Kyung; Gao, Fang; Lee, Dong‐Soo; Han, Jong-Min; Son, Chang‐Gue

doi:10.3109/13880209.2013.770040

Cited by 18 publications

(14 citation statements)

References 36 publications

(32 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Both WAX and MFAX attenuated the hepatofibrotic alterations via modulation of antioxidant and anti-inflammatory effects [11, 44]. However, WAX and MFAX were potent in their antihepatofibrotic activity near a dose of 100 mg/kg, whereas a very low dose of EFAX (25 mg/kg) showed notable activity in the present study.…”

Section: Discussioncontrasting

confidence: 51%

Ethyl Acetate Fraction of Amomum xanthioides Exerts Antihepatofibrotic Actions via the Regulation of Fibrogenic Cytokines in a Dimethylnitrosamine‐Induced Rat Model

Lee

Kim

et al. 2016

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

Amomum xanthioides has been traditionally used to treat diverse digestive system disorders in the Asian countries. We investigated antihepatofibrotic effects of ethyl acetate fraction of Amomum xanthioides (EFAX). Liver fibrosis is induced by dimethylnitrosamine (DMN) injection (intraperitoneally, 10 mg/kg of DMN for 4 weeks to Sprague-Dawley rats). EFAX (25 or 50 mg/kg), silymarin (50 mg/kg), or distilled water was orally administered every day. The DMN injection drastically altered body and organ mass, serum biochemistry, and platelet count, while EFAX treatment significantly attenuated this alteration. Severe liver fibrosis is determined by trichrome staining and measurement of hydroxyproline contents. EFAX treatment significantly attenuated these symptoms as well as the increase in oxidative by-products of lipid and protein metabolism in liver tissues. DMN induced a dramatic activation of hepatic stellate cells and increases in the levels of protein and gene expression of transforming growth factor-beta (TGF-β), platelet derived growth factor-beta (PDGF-β), and connective tissue growth factor (CTGF). Immunohistochemical analyses revealed increases in the levels of protein and gene expression of α-smooth muscle actin. These alterations were significantly normalized by EFAX treatment. Our findings demonstrate the potent antihepatofibrotic properties of EFAX via modulation of fibrogenic cytokines, especially TGF-β in the liver fibrosis rat model.

show abstract

Section: Discussioncontrasting

confidence: 51%

Ethyl Acetate Fraction of Amomum xanthioides Exerts Antihepatofibrotic Actions via the Regulation of Fibrogenic Cytokines in a Dimethylnitrosamine‐Induced Rat Model

Lee

Kim

et al. 2016

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…The seed of A. xanthioides is listed in the Japanese Pharmacopoeia as 'Amomum seed' (18). Although their total composition remains unclear, the seeds commonly contain five primary classes of components, including volatile oils, saponins, flavonoid glycosides, organic acids and inorganic components (19). Specifically, they contain 1-1.5% essential oil that is rich in monoterpenoids (borneol, linalool, camphene and nerolidol), which are reported to exhibit numerous pharmacological properties, including antimicrobial, anti-inflammatory, anti-oxidant, anti-pruritic, hypotensive and analgesic activities (20).…”

Section: Amentioning

confidence: 99%

Anti-inflammatory effect of Amomum xanthioides in a mouse atopic dermatitis model

Choi

Jang

et al. 2017

Molecular Medicine Reports

View full text Add to dashboard Cite

Atopic dermatitis (AD) is a chronic relapsing inflammatory skin disorder. The present study investigated the effects of Amomum xanthioides extract (AXE) on AD‑like skin inflammation using a Dermatophagoides farinae extract (DFE) and 2,4‑dinitrochlorobenzene (DNCB)‑induced mouse AD model. Hematoxylin and eosin staining results demonstrated that repeated DFE/DNCB exposure markedly increased the thickening of the dermis and epidermis, in addition to the infiltration of eosinophils and mast cells. However, oral administration of AXE reduced these histopathological alterations in a dose‑dependent manner. Elevated serum histamine, total and DFE‑specific immunoglobulin E (IgE), and IgG2a were also decreased by treatment with AXE. In addition, reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) results demonstrated that the mRNA expression of tumor necrosis factor (TNF)‑α, interferon (IFN)‑γ, interleukin (IL)‑4, IL‑13, IL‑31 and IL‑17A was reduced in ear skin following AXE administration in AD mice. Fluorescence‑activated cell sorting demonstrated that the population of CD4+/IL‑4+, CD4+/IFN‑γ+ and CD4+/IL‑17A+ cells in draining lymph nodes was also significantly decreased in AXE‑treated mice compared with AD mice without AXE treatment. Furthermore, keratinocytes that were stimulated with TNF‑α and IFN‑γ exhibited increased gene expression of pro‑inflammatory cytokines and chemokines, including TNF‑α, IL‑1β, IL‑6, IL‑8, C‑C motif chemokine ligand (CCL)17 and CCL22, as determined by RT‑qPCR. However, upregulation of these genes was reduced by AXE pretreatment. Based on these results, we hypothesize that AXE may be useful in the treatment of allergic skin inflammation, particularly AD.

show abstract

“…Hepatoprotective effect of W. villosa var. xanthioides was also reported from a chronic liver injury model (Wang et al, 2013). Furthermore, S. miltiorrhiza showed the neuroprotective actions against the psychological stress (Kim et al, 2015).…”

Section: A B C Dmentioning

confidence: 88%

An Herbal Formula CGplus Ameliorates Stress-Induced Hepatic Injury in a BALB/c Mouse Model

Kim

Lee

et al. 2020

Front. Pharmacol.

Self Cite

View full text Add to dashboard Cite

Introduction: Stress is a well-known factor for inflammation in diverse organs/tissues. Stress also leads to liver injury, which was supported by clinical observations and animal studies. We herein investigated the hepatoprotective property of an herbal formula (called as CG plus) consisting of Artemisia gmelinii Weber ex Stechm. (syn, Artemisia iwayomogi Kitamura), Wurfbainia villosa var. xanthioides (Wall. ex Baker) Skornick. & A.D.Poulsen (syn, Amomum xanthioides Wallich), and Salvia miltiorrhiza Bunge against stress-induced hepatic damage. Methods: Male BALB/c mice were orally administered water extract of CG plus (0, 50, 100, or 200 mg/kg) daily for 5 days, and then subjected to immobilization stress for 6 h on the 5 th day. Results: Acute immobilization stress elevated remarkably serum concentrations of stress hormones (corticosterone and adrenaline) and two hepatic injury parameters (ALT and AST), while these alterations were significantly attenuated by the administration of CG plus. The increases of oxidative parameters (ROS, NO, lipid peroxidation, and protein carbonyl) and deviation of IL-1b and IL-10 in opposite directions in hepatic tissues were significantly normalized by CG plus. Pre-treatment with CG plus also notably ameliorated the abnormal activation of toll-like receptor 4 (TLR4), CD14, and lipopolysaccharide-binding protein (LPB) as well as infiltration of neutrophils in hepatic tissues. Conclusion: These results suggest that an herbal formula (CG plus) derived from traditional pharmaceutical theory has a potent protective effect against stress-induced hepatic injury via regulation of pro-(IL-1b) and anti-inflammatory (IL-10) cytokines.

show abstract

Hepatoprotective effect ofAmomum xanthoidesagainst dimethylnitrosamine-induced sub-chronic liver injury in a rat model

Cited by 18 publications

References 36 publications

Ethyl Acetate Fraction of Amomum xanthioides Exerts Antihepatofibrotic Actions via the Regulation of Fibrogenic Cytokines in a Dimethylnitrosamine‐Induced Rat Model

Ethyl Acetate Fraction of Amomum xanthioides Exerts Antihepatofibrotic Actions via the Regulation of Fibrogenic Cytokines in a Dimethylnitrosamine‐Induced Rat Model

Anti-inflammatory effect of Amomum xanthioides in a mouse atopic dermatitis model

An Herbal Formula CGplus Ameliorates Stress-Induced Hepatic Injury in a BALB/c Mouse Model

Contact Info

Product

Resources

About