Hepatoprotective effect of ethanol extract of matoa leaves (Pometia pinnata) against paracetamol-induced liver disease in rats

Abstract

The hepatoprotective effects of matoa leaves were evaluated by paracetamol-induced injury in rat's hepatocytes. The ethanolic extract of matoa leaves (EEML) at doses of 200, 300, 500 mg/kg, po and silymarin at dose of 100 mg/kg, po were given for seven days. Silymarin was given as the reference drug. Hepatoprotective effect was studied by measuring the level of AST, ALT, ALP and total protein in serum. In vivo, oral treatment with EEML at dose of 500 mg/kg significantly reduced AST, ALT, ALP in serum whereas total protein was not significantly reduce in each groups. These results indicate that the hepatoprotective action of EEML is likely related to its potent antioxidative activity. Neutralizing reactive oxygen species enhancing the activity of original natural hepatic-antioxidant enzymes may be the main mechanisms of EEML against paracetamol-induced injury.

Hepatoprotective Potential of Tecomella undulata Bark on Paracetamol and CCL4 Induced Hepatotoxicity in Rats: Invitro Analysis

“…At the end of the experimental period, the rats were fasted overnight and sacrificed by ether. Blood and liver samples were collected for biochemical analysis [11].…”

Assessment of Hepatoprotective Potential of Manilkara hexandra STEM Bark: An In-vitro Analysis

“…Carbon tetrachloride (CCl 4 ) induced hepatotoxicity model was adopted for the study [12]. The rats were divided into 5 groups of 6 animals each.…”

“…At a higher dose of extract, the promising effect was seen (Tables 18-23 Figs. [11][12][13][14][15][16][17]. [18].…”

“…Consequently, in the current examination, we expected to build up the reasonableness of the leaves of M. hexandra over the stem barks for the pharmacological exercises. In numerous investigations, the cell reinforcements were segregated with methanol and our previous information additionally demonstrated that the methanolic separate portion had the most elevated in vitro cancer prevention agent exercises (12). Thus in this study, it was aimed at the Hepatoprotective Activity potential of Manilkara Hexendera Bark.…”