Hepatoprotective Effect of Essential Oils from<i>Hyptis crenata</i>in Sepsis-Induced Liver Dysfunction

Lima, Glauber Cruz; Vasconcelos, Yuri; Souza, Marília Trindade de Santana; Oliveira, Alan Santos; Bomfim, Rangel Rodrigues; Júnior, Ricardo Luiz Cavalcanti de Albuquerque; Camargo, Enilton A.; Portella, Viviane Gomes; Coelho‐de‐Souza, Andrelina Noronha; Diniz, Lúcio Ricardo Leite

doi:10.1089/jmf.2017.0125

Cited by 14 publications

(10 citation statements)

References 34 publications

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“…There are some works showing that monoterpene compounds present in EOHc have anti-inflammatory activity (25)(26)(27). The main components of EOHc are monoterpenoid and sesquiterpene compounds (28), such as camphor, alpha-pinene, 1.8-cineole, and beta-caryophyllene (4,10,11,14). Therefore, EOHc, used traditionally for treatment of inflammatory diseases, also has antiinflammatory activity, as demonstrated here.…”

Section: Discussionmentioning

confidence: 53%

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The essential oil of Hyptis crenata Pohl ex Benth. presents an antiedematogenic effect in mice

Coelho‐de‐Souza

Soares

Oliveira

et al. 2021

Braz J Med Biol Res

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Hyptis crenata , commonly known as “salva-do-Marajó”, “hortelã-do-campo”, and “hortelãzinha”, is used in folk medicine in Northeast Brazil as tea or infusion to treat inflammatory diseases. Due to the pharmacological efficacy and the low toxicity of the essential oil of Hyptis crenata (EOHc), we decided to investigate the EOHc antiedematogenic effect in experimental models of inflammation. EOHc was administrated orally at doses of 10-300 mg/kg to male Swiss albino mice. Paw edema was induced by subcutaneous injection in the right hind paw of inflammatory stimuli (carrageenan, dextran, histamine, serotonin, and bradykinin) 60 min after administration of EOHc. EOHc significantly inhibited the induced edema. The inhibitory effect of EOHc on dextran-induced edema extended throughout the experimental time. For the 30, 100, and 300 mg/kg doses of EOHc, the inhibition was of 40.28±1.70, 51.18±2.69, and 59.24±2.13%, respectively. The EOHc inhibitory effect on carrageenan-induced edema started at 10 mg/kg at the second hour (h) and was maintained throughout the observation period. At 30, 100, and 300 mg/kg doses the inhibition started earlier, from 30 min. At the edema peak of 180 min, 56, 76, and 82% inhibition was observed for 30, 100, and 300 mg/kg doses, respectively. Additionally, the effect of EOHc on carrageenan-induced paw edema was influenced by the time of administration. The EOHc also inhibited myeloperoxidase activity. In conclusion, the EOHc showed a potent effect, both preventing and reversing the edema, consistent with its anti-inflammatory use in folk medicine.

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Section: Discussionmentioning

confidence: 53%

“…The EOHc was obtained from leaves and branches of H. crenata by steam distillation (Detiller MA480, Marconi s , Brazil) as described for other essential oils (8,(14)(15)(16)(17)(18). The plant was collected (January 2011) in the city of São Raimundo das Mangabeiras, Maranhão State, Brazil (7°1 0 19 00 S, 45°28 0 51 00 W).…”

Section: Essential Oil Extractionmentioning

confidence: 99%

The essential oil of Hyptis crenata Pohl ex Benth. presents an antiedematogenic effect in mice

Coelho‐de‐Souza

Soares

Oliveira

et al. 2021

Braz J Med Biol Res

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“…(‘ hortelã‐do‐campo ’) [25] leaves was administered to rats submitted to a puncture model of polymicrobial sepsis, showing a protective effect against liver injury. At a dose of 300 mg/kg, the oil normalized serum ALP, ALT and bilirubin levels, inhibited the elevation in hepatic lipid peroxidation, and reduced GSH peroxidase activity induced by sepsis, maintaining liver morphology [94] . A pre‐treatment with the methanolic extract obtained from the whole plant of Hyptis suaveolens Poit., known as ‘ bamburral ,’ [43] at doses of 50 and 100 mg/kg, produced a marked decrease in serum transaminases, restored hepatic antioxidant activities and attenuated liver damage induced by CCl 4 in rats in a 7‐day experiment [95] …”

Section: Resultsmentioning

confidence: 99%

Hepatoprotective Native Plants Documented in Brazilian Traditional Medicine Literature: Current Knowledge and Prospects

Arbo

Konrath

2022

Chemistry & Biodiversity

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The native flora of Brazil covers a large biodiversity of plants, some of which have important pharmacological properties. Ethnobotanical studies have established that the folk use of plants for hepatobiliary disorders is very common in Brazil. This review aimed to compile, describe and discuss the main native Brazilian medicinal plants used as hepatoprotective agents listed on 25 books by authors from various regions in the country. Based on the 153 species found, a comprehensive analysis of the most relevant scientific studies is presented, including Piper umbellatum, Echinodorus macrophyllus, Fevillea trilobata and Achyrocline satureioides. Some medicinal plants share both a large number of citations and scientific evidence to corroborate their hepatoprotective effects, including Solanum paniculatum, Baccharis crispa and Phyllanthus niruri, which could be of interest to develop new phytomedicines. Additionally, some active ingredients are indicated as being responsible for the liver protective effects described, particularly phenolic compounds (flavonoids, coumestans and lignans).

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“…Prospectively, new medical instruments and further investigations about the role of the human microbiome in regulating healthy and pathologic conditions could give us a number of fundamental information about the pathophysiologic mechanisms of the sepsis [50,51,52,53,54]. Moreover, both the arising knowledge on antibiotic activity of plant extracts [55,56,57,58,59,60,61,62] and on the immune modulating effect of probiotics will be helpful to develop most rapid and economic protocols for septic patients [63,64,65,66,67,68,69,70,71,72,73].…”

Section: Discussionmentioning

confidence: 99%

Current Issues and Perspectives in Patients with Possible Sepsis at Emergency Departments

et al. 2019

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In the area of Emergency Room (ER), many patients present criteria compatible with a SIRS, but only some of them have an associated infection. The new definition of sepsis by the European Society of Intensive Care Medicine and the Society of Critical Care Medicine (2016), revolutionizes precedent criteria, overcoming the concept of SIRS and clearly distinguishing the infection with the patient’s physiological response from the symptoms of sepsis. Another fundamental change concerns the recognition method: The use of SOFA (Sequential-Sepsis Related-Organ Failure Assessment Score) as reference score for organ damage assessment. Also, the use of the qSOFA is based on the use of three objective parameters: Altered level of consciousness (GCS <15 or AVPU), systolic blood pressure ≤ 100 mmHg, and respiratory rate ≥ 22/min. If patients have at least two of these altered parameters in association with an infection, then there is the suspicion of sepsis. In these patients the risk of death is higher, and it is necessary to implement the appropriate management protocols, indeed the hospital mortality rate of these patients exceeds 40%. Patients with septic shock can be identified by the association of the clinical symptoms of sepsis with persistent hypotension, which requires vasopressors to maintain a MAP of 65 mmHg, and serum lactate levels >18 mg/dL in despite of an adequate volume resuscitation. Then, patient first management is mainly based on: (1) Recognition of the potentially septic patient (sepsis protocol-qSOFA); (2) Laboratory investigations; (3) Empirical antibiotic therapy in patients with sepsis and septic shock. With this in mind, the authors discuss the most important aspects of the sepsis in both adults and infants, and also consider the possible treatment according current guidelines. In addition, the possible role of some nutraceuticals as supportive therapy in septic patient is also discussed.

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Hepatoprotective Effect of Essential Oils fromHyptis crenatain Sepsis-Induced Liver Dysfunction

Cited by 14 publications

References 34 publications

The essential oil of Hyptis crenata Pohl ex Benth. presents an antiedematogenic effect in mice

The essential oil of Hyptis crenata Pohl ex Benth. presents an antiedematogenic effect in mice

Hepatoprotective Native Plants Documented in Brazilian Traditional Medicine Literature: Current Knowledge and Prospects

Current Issues and Perspectives in Patients with Possible Sepsis at Emergency Departments

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