Hepatoprotective effect of Descurainia sophia seed extract against paracetamol-induced oxidative stress and hepatic damage in mice

Moshaei-Nezhad, Pedram; Iman, Maryam; Maleki, Firouz Faed; Khamesipour, Ali

doi:10.15171/jhp.2018.40

Cited by 13 publications

(8 citation statements)

References 20 publications

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“…The mechanism of acetaminophen-induced nephrotoxicity and hepatotoxicity has been reported by other investigators and showed that paracetamol causes oxidative stress and renal toxicity when used at high doses (21)(22)(23)(24)(25)(26).…”

Section: Discussionmentioning

confidence: 63%

Protective effect of ivy leaf extract on paracetamol-induced oxidative stress and nephrotoxicity in mice

Moshaei-Nezhad¹,

Hosseini²,

Yahyapour³

et al. 2019

J Herbmed Pharmacol

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Section: Discussionmentioning

confidence: 63%

Protective effect of ivy leaf extract on paracetamol-induced oxidative stress and nephrotoxicity in mice

Moshaei-Nezhad¹,

Hosseini²,

Yahyapour³

et al. 2019

J Herbmed Pharmacol

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“…Additionally, many other cellular processes such as endoplasmic reticulum stress, autophagy, sterile inflammation, microcirculatory dysfunction, and liver regeneration have been identified to be involved in the pathogenesis of APAP-induced liver injury [ 44 ]. Necrosis, vacuolar degeneration, and inflammatory cell infiltration were also seen after APAP administration [ 52 ]. Degrees of both necrosis and vacuolar degeneration were higher in the negative control group, which received only APAP compared with a normal control group in the present study.…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective Effects of Crude Stem Bark Extracts and Solvent Fractions of Cordia africana against Acetaminophen-Induced Liver Injury in Rats

Geresu

Umer

Arayaselassie

et al. 2022

Canadian Journal of Gastroenterology and Hepatology

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Cordia africana Lam (Boraginaceae) is widely used in Ethiopian folk medicine for the treatment of different types of liver disorders. Thus, this study aimed to investigate the hepatoprotective effects of an aqueous (CAAE), 80% methanol extracts of C. africana stem bark (CAME), and the solvent fractions of the methanol extract against acetaminophen (APAP)-induced liver injury in rats. Acute toxicity test and APAP-induced lethality test were done on mice of either sex, while APAP dose selection test was done on female rats. Male rats were used for hepatoprotective experiments and the liver injury was induced using 2 g/kg APAP given orally. Serum levels of the liver enzymes and total bilirubin (TB), as well as lipid profiles, were determined. Histopathological examination of the liver tissues was also conducted to confirm the findings of biochemical analysis. Intraperitoneal (i.p.) sodium pentobarbital (SPB)-induced sleeping duration was also used to determine the protective effect of the test substances. Oral administration of APAP resulted in a significant increase in serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), TB, low-density lipoprotein (LDL), total cholesterol (TC), and triglycerides (TGs) and decrease in serum high-density lipoprotein (HDL). Administration of the standard drug, silymarin 100 mg/kg, extracts at doses of 100, 200, and 400 mg/kg and fractions at the dose of 400 mg/kg reversed the serum levels of all parameters to normal. CAME exerted a significant dose-dependent hepatoprotective effect in terms of ALT and AST, while CAAE significant dose-dependent hepatoprotective effect was in terms of AST, ALP, and TGs. The protective effect of the extracts and fractions was also confirmed by histopathological investigations and SPB-induced sleeping time. From the results of the present study, it can be concluded that C. africana stem bark aqueous, 80% methanol crude extracts, and solvent fractions of the methanol extract showed hepatoprotective effects.

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“…Furthermore, the moderate ash content may clearly implicate in the treatment and management of drug-induced toxicity. Acetaminophen (APAP), a commonly used analgesic, and the antipyretic drug are metabolized by CYP450 enzymes to give N-acetyl-P benzoquinone-imine at extreme doses correspondingly causing covalent binding to thiol groups of reduced glutathione in the liver and kidney, depleting glutathione, and increasing the risk for hepatotoxicity [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Ficus exasperata Attenuates Acetaminophen-Induced Hepatic Damage via NF-κB Signaling Mechanism in Experimental Rat Model

Adetuyi¹,

Adebisi

Adetuyi

et al. 2022

BioMed Research International

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Ficus exasperata has been used to treat ulcer, diabetes, fever, and a variety of stress-related disorders. Acetaminophen (APAP) overdose is the most common cause of drug-induced acute liver injury. In this study, we evaluated the hepatoprotective effect and antioxidant capacity of ethanolic extract of F. exasperata (EFE) on acetaminophen-induced hepatotoxicity in albino rats. Rats were pretreated with EFE (150, 250, 500 mg/kg) and thereafter received 250 mg/kg APA intraperitoneally (i.p.). The normal control group received distilled water, while the negative control group received 250 mg/kg APAP, respectively. Hepatotoxicity and oxidative stress-antioxidant parameters were then assessed. Flavonoids, saponins, steroids, and glycosides, but not phenolics were detected by EFE phytochemical analysis. No mortality was recorded on acute exposure of rats to varying concentrations of APAP after 24 h; however, a dose-dependent increase in severity of convulsion, urination, and hyperactivity was observed. APAP overdose induced high AST, ALT, ALP, and total bilirubin levels in the serum, invoked lipid peroxidation, depleted GSH, decreased CAT, SOD, and GST levels, respectively. Nitric oxide (NO) level, myeloperoxidase activity, TNF-α, IL-1β, NF-κB, COX-2, MCP-1, and IL-6 were also increased. Importantly, pretreatment of rats with EFE before acetaminophen ameliorated and restored cellular antioxidant status to levels comparable to the control group. Our results show and suggest the hepatoprotective effect of F. exasperata and its ability to modulate cellular antioxidant status supports its use in traditional medicine and renders it safe in treating an oxidative stress-induced hepatic injury.

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Hepatoprotective effect of Descurainia sophia seed extract against paracetamol-induced oxidative stress and hepatic damage in mice

Abstract: Results demonstrate that D. sophia seed extract is able to limit the paracetamol-induced oxidative and hepatic damages in the liver. Further studies are required to confirm the mechanisms responsible for hepatoprotective activity.

Cited by 13 publications

References 20 publications

Protective effect of ivy leaf extract on paracetamol-induced oxidative stress and nephrotoxicity in mice

Protective effect of ivy leaf extract on paracetamol-induced oxidative stress and nephrotoxicity in mice

Hepatoprotective Effects of Crude Stem Bark Extracts and Solvent Fractions of Cordia africana against Acetaminophen-Induced Liver Injury in Rats

Ficus exasperata Attenuates Acetaminophen-Induced Hepatic Damage via NF-κB Signaling Mechanism in Experimental Rat Model

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