Hepatoprotective Effect of C-Phycocyanin: Protection for Carbon Tetrachloride andR-(+)-Pulegone-Mediated Hepatotoxicty in Rats

Vadiraja, Bhat.B.; Gaikwad, Nilesh W.; Madyastha, K. M.

doi:10.1006/bbrc.1998.9149

Cited by 192 publications

(102 citation statements)

References 15 publications

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“…Phycobiliproteins (PBPs) constitute around 60 % of the total protein content and 20 % of the dry cell weight of cyanobacteria (Soni et al 2008). Till date, they have been reported as potent pharmacological and medicinal agent having hepato-protective (Vadiraja et al 1998), anti-inflammatory (Romay et al 2003), anti-cancerous , anti-Alzheimer's disease , and antioxidant activity (Sonani et al 2014;Soni et al 2008). Moreover, PBPs are also utilized as natural colorants in food products like chewing gums, dairy products, jellies as well as in cosmetics (Rasmussen and Morrissey 2007).…”

Section: Introductionmentioning

confidence: 99%

Phycoerythrin extends life span and health span of Caenorhabditis elegans

Sonani

Singh²,

Awasthi

et al. 2014

AGE

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In the present study, we tested the antioxidant activity of phycoerythrin (PE, an oligomeric light harvesting protein isolated from Lyngbya sp. A09DM) to curtail aging effects in Caenorhabditis elegans. Purified PE (100 μg/ml) dietary supplement was given to C. elegans and investigated for its anti-aging potential. PE treatment improved the mean life span of wild type (N2)-animals from 15±0.1 to 19.9±0.3 days. PE treatment also moderated the decline in aging-associated physiological functions like pharyngeal pumping and locomotion with increasing age of N2 worms. Moreover, PE treatment also enhanced the stress tolerance in 5-day-aged adults with increase in mean survival rate from 22.2±2.5 to 41.6±2.5 % under thermo stress and from 30.1±3.2 to 63.1±6.4 % under oxidative (hydrogen peroxide)-stress. PE treatment was also noted to moderate the heat-induced expression of human amyloid-beta(Aβ 1-42 ) peptide and associated paralysis in the muscle tissues of transgenic C. elegans CL4176 (Alzheimer's disease model). Effectiveness of PE in expanding the life span of mutant C. elegans, knockout for some up (daf-2 and age-1)-and down (daf-16)-stream regulators of insulin/IGF-1 signaling (IIS), shows the independency of PE effect from DAF-2-AGE-1-DAF-16 signaling pathway. Moreover, the inability of PE in expanding the life span of hsf-1 knockout C. elegans(sy441) suggests the dependency of PE effect on heat shock transcription factor (HSF-1) controlling AGE (2014) stress-induced gene expression. In conclusion, our results demonstrated a novel anti-aging activity of PE which conferred increased resistance to cellular stress resulting in improved life span and health span of C. elegans.

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Section: Introductionmentioning

confidence: 99%

Phycoerythrin extends life span and health span of Caenorhabditis elegans

Sonani

Singh²,

Awasthi

et al. 2014

AGE

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“…A sequential energy transfer mechanism transfers the light energy to the photosystems where the process of photosynthesis is carried out. Due to their fluorescent properties, they have found uses as food colorant, fluorescent probes and markers, neuro and hepato-protective agents and anti-oxidant molecules (Vadiraja et al, 1998;Romay et al, 2003;Sekar and Chandramohan, 2007). The UV-visible spectra of the Lyngbya extract had a characteristic peak at 565 nm which is identical to the absorption maximum of purified C-PE.…”

Section: Characterization Of Cyanobacterial Extracts and Purified Pigmentioning

confidence: 99%

Cyanobacterial Pigments as Natural Anti-Hyperglycemic Agents: An In vitro Study

et al. 2016

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Traditional medicines for controlling postprandial hyperglycemia includes herbs and plant extracts as well as synthetic drugs like acarbose. Synthetic drug molecules frequently have side effects such as flatulence and diarrhea. Cyanobacterial pigments have excellent anti-oxidant and free radical scavenging properties. Thus, α-amylase and α-glucosidase inhibiting activities of purified pigments and crude extracts from three cyanobacterial species, Lyngbya, Microcoleus, and Synechocystis sp., were investigated. Lyngbya extract had the highest total anti-oxidant activity (TAC) before digestion (48.26 ± 0.04 µg AAE ml −1 ) while purified lycopene had the highest TAC after digestion (154.16 ± 0.96 µg AAE ml −1 ). The Microcoleus extract had the highest ABTS scavenging activity before digestion (98.23 ± 0.25%) while purified C-phycocyanin (C-PC) had the highest ABTS scavenging after digestion (99.69 ± 0.04%). None of the digested or undigested extracts performed better than acarbose in inhibiting α-amylase but the digested Microcoleus extract was able to inhibit its activity by ∼35%. The purified pigments gave inhibitory activities ranging from ∼8 to 16%. The Lyngbya extract had the highest inhibitory activity against α-glucosidase both before and after digestion (62.22 ± 0.02 and 97.82 ± 0.03%, respectively). Purified C-phycoerythrin (C-PE), C-PC, lycopene and myxoxanthophyll could inhibit α-glucosidase in a range of ∼83-96%. Considering the potent inhibitory activities of purified pigments against both α-amylase and α-glucosidase, cyanobacterial pigments could be used as food additives for their dual advantage of anti-oxidant and anti-hyperglycemic activities.

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“…Phycocyanin contain a higher level of cystine than control diet, the differences in amino acid content may relate to the differences in serum cholesterol concentrations. Phycocyanin has antioxidant action [27,37] and confers cholesterol degradation effect against liver damage induced by CCl 4 [38]. In Spirulina antioxidant compounds like Phycocyanin, Poly-unsaturated fatty acid may be the reason to decrease of serum cholesterol level.…”

Section: Effect Of Cyanobacterial Diets On Blood Cholesterol Of Albinmentioning

confidence: 99%

Cholesterol Degradation Effect Analyzed using Marine Cyanobacterial Species Spirulina subsalsa

Sakthivel¹

2015

J Microb Biochem Technol

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In this study was designed to understand the mechanisms of cholesterol degradation by cyanobacterial species Spirulina subsalsa. We analyzed the degradation of cholesterol in albino mice using basal feed diet (control) and different concentration (1%, 2% and 4%) of cyanobacterial diet. Cholesterol was estimated from the control and cyanobacterial fed to the albino mice. Blood cholesterol level reduced 8.1, 24.3, 30.6 % in 1, 2 and 4% cyanobacterial diet respectively. Phycobiliproteins are the most abundant soluble protein complexes in cyanobacteria and phycocyanin have 75% in phycobiliprotein. We concluded, phycocyanin was major role for cholesterol degradation in albino mice.

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Hepatoprotective Effect of C-Phycocyanin: Protection for Carbon Tetrachloride andR-(+)-Pulegone-Mediated Hepatotoxicty in Rats

Cited by 192 publications

References 15 publications

Phycoerythrin extends life span and health span of Caenorhabditis elegans

Phycoerythrin extends life span and health span of Caenorhabditis elegans

Cyanobacterial Pigments as Natural Anti-Hyperglycemic Agents: An In vitro Study

Cholesterol Degradation Effect Analyzed using Marine Cyanobacterial Species Spirulina subsalsa

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