Hepatoprotective Effect of Aqueous Extract of Lippia multiflora Leaves against Ethanol-induced Toxicity in Wistar Rats

Bouagnon, Rita; Yeo, Dodehe; Kouassi, Konan Édouard; Beugre, K.; Djaman, Joseph Allico; N’Guessan, Jean David

doi:10.9734/ejmp/2015/16394

Cited by 5 publications

(6 citation statements)

References 14 publications

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“…At J18 of post-partum, experimental lactating rats were anesthetized with ethyl urethane and sacrificed [30]. Then the upper abdominal pairs of the mammary glands were taken for histological study according to the standard method described by Bouagnon et al [31] and Zougrou et al [32]. Sections were taken from abdominal tissues, dehydrated in gradual ethanol, cleared in toluene and infiltrated in paraffin using automatic tissue processor.…”

Section: Histological Study Of Mammary Glandmentioning

confidence: 99%

Galactagogue Effect of <i>Euphorbia hirta</i> (Euphorbiaceae) Aqueous Leaf Extract on Milk Production in Female Wistar Rats

Koko¹,

Konan²,

Kouacou³

et al. 2019

JBM

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Background: Populations of Gontougo (Côte d'Ivoire) commonly used Euphorbia hirta (Euphorbiaceae) leaves as galactagogue to boost milk production in lactating women. Our study was carried to verify this traditional belief via evaluations of milk production, serum prolactin levels, body weight and mammary lobuloalveolar proliferation induced by the aqueous leaf extract of this medicinal plant in Wistar rats. Methods: 6 groups of 6 virgin rats and 6 groups of 6 lactating rats were used. Each lactating rat was isolated with its six pups. These groups of animals were treated orally with distilled water, Metoclopramide (Metocl 5 mg/kg) and E. hirta aqueous leaf extract (EHae 100, 200, 400 and 600 mg/kg) daily during 17 days of lactation. The indirect method which assimilates the weight gain of untreated pups to the quantity of milk produced by lactating rats was used. At the end of the treatment, histological sections of the abdominal mammary glands of lactating rats were observed. Results: EHae administration induced an increase of milk production in lactating rats. This action of EHae was stronger at the dose of 200 mg/kg. Milk production of the treated rats at a dose of 200 mg/kg was 118.14 ± 1 g. The quantity of milk produced by the control female rats was 83.83 ± 0.88 g. Compared with the control, EHae 200 mg/kg significantly increased milk production (40.92%) (P < 0.0001). EHae 200 mg/kg significantly increased the biosynthesis of prolactin (PRL) in virgin rats (P < 0.0001). At this dose, PRL values measured at D7 and D14 were 26.44 ± 8.64 and 33.88 ± 7.30 ng/ml respectively, whereas the value obtained in the controls that received distilled water was less than 0.5 ng/ml. Histological analysis showed that EHae 200 mg/kg induced the development of the lobuloalveolar system of the mammary glands. Conclusion: EHae showed a galactagogue activity illustrated by increases of milk production, PRL secretions and the development How to cite this paper: .79006 52 Journal of Biosciences and Medicines of the lobuloalveolar system of the mammary glands in treated female rats. This galactagogue property could partly justify the traditional use of this plant to boost milk production in lactating women.

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Section: Histological Study Of Mammary Glandmentioning

confidence: 99%

Galactagogue Effect of <i>Euphorbia hirta</i> (Euphorbiaceae) Aqueous Leaf Extract on Milk Production in Female Wistar Rats

Koko¹,

Konan²,

Kouacou³

et al. 2019

JBM

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“…Lippia multiflora, also known as savannah tea, savannah tea bush or Gambia tea, is known to the people of northern, central and eastern Côte d'Ivoire, who use it in infusions as an anti-fatigue drink and to treat insomnia, fever, hypertension and liver disease [14,1,15]. In addition, a number of biological and pharmacological studies conducted on this plant have shown that it has relaxing and analgesic properties, as well as antioxidant properties [16]; hepatoprotective [17].…”

Section: Formulation Of Teasmentioning

confidence: 99%

Sensory Analysis and Physicochemical Parameters of Three "TEAS" Formulations Obtained from Aromatic Plant Powders from Côte d’Ivoire

Epiphanie,

Elisée,

Christine

et al. 2023

JAFSAT

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The use of plants by humans for their nutritional, health and wellness needs dates back to ancient times. This trend has increased to date with the boom in the tea/tisane market. The aim of this project is to gather scientific data on three 'teas' formulations obtained from aromatic plant resources commonly used in food. For this purpose, the species Lippia multiflora, Hibiscus sabdariffa, Zingiber officinale and Adansonia digitata were harvested, processed into powders and then combined two by two in precise proportions, keeping L. multiflora as the species common to the different formulations. A sensory analysis using the hedonic test was carried out on each of the formulations by a panel of tasters, and then some physico-chemical parameters of these formulations were determined. All three formulations were appreciated by the tasters. "However, the TEA 3 formulation "L. multiflora + Z. officinale" was the most popular. The pH values of the formulations ranged from 3.5 to 7.5. The ash content ranged from 7% to 10%. The total polyphenol content ranged from 12 to 17 mg gallic acid equivalent/g and the total flavonoid content ranged from 15 to 20 µg quercetin equivalent/g. Concentrations of total sugars and reducing sugars expressed as mg glucose equivalent/g ranged from 10 and 20.36 and 0.2 and 0.46, respectively. Fat content (%) varied from 3.5 to 4.6. The formulated TEAS contain compounds of therapeutic and nutritional interest that could enter the nutraceutical market in Côte d'Ivoire for the well-being of consumers.

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“…The aqueous extract of L. multiflora Mold has vasodilating, hypotensive and cardio-moderating effects [ 31 , 39 , 40 , 41 ]. It provides significant protection against ethanol-induced toxicity in rat livers [ 42 ]. Furthermore, other types of extracts and their phytochemicals showed antioxidant, antimicrobial, antiplasmodial, and anti-inflammatory activities [ 43 , 44 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antibacterial Activity of Lippia multiflora Moldenke Essential Oil from Different Regions of Angola

et al. 2020

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The purpose of the study was to determine the chemical composition and antibacterial activity of Lippia multiflora Moldenke essential oils (EOs) collected in different regions of Angola. Antibacterial activity was evaluated using the agar wells technique and vapour phase test. Analysis of the oils by GC/MS identified thirty-five components representing 67.5 to 100% of the total oils. Monoterpene hydrocarbons were the most prevalent compounds, followed by oxygenated monoterpenes. The content of the compounds varied according to the samples. The main components were Limonene, Piperitenone, Neral, Citral, Elemol, p-cymene, Transtagetone, and Artemisia ketone. Only one of the eleven samples contained Verbenone as the majority compound. In the vapour phase test, a single oil was the most effective against all the pathogens studied. The principal component analysis (PCA) and hierarchical cluster analysis (HCA) of components of the selected EOs and inhibition zone diameter values of agar wells technique allowed us to identify a variability between the plants from the two provinces, but also intraspecific variability between sub-groups within a population. Each group of essential oils constituted a chemotype responsible for their bacterial inhibition capacity. The results presented here suggest that Angolan Lippia multiflora Moldenke has antibacterial properties and could be a potential source of antimicrobial agents for the pharmaceutical and food industry.

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Hepatoprotective Effect of Aqueous Extract of Lippia multiflora Leaves against Ethanol-induced Toxicity in Wistar Rats

Cited by 5 publications

References 14 publications

Galactagogue Effect of <i>Euphorbia hirta</i> (Euphorbiaceae) Aqueous Leaf Extract on Milk Production in Female Wistar Rats

Galactagogue Effect of <i>Euphorbia hirta</i> (Euphorbiaceae) Aqueous Leaf Extract on Milk Production in Female Wistar Rats

Sensory Analysis and Physicochemical Parameters of Three "TEAS" Formulations Obtained from Aromatic Plant Powders from Côte d’Ivoire

Chemical Composition and Antibacterial Activity of Lippia multiflora Moldenke Essential Oil from Different Regions of Angola

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Hepatoprotective Effect of Aqueous Extract of Lippia multiflora Leaves against Ethanol-induced Toxicity in Wistar Rats

Cited by 5 publications

References 14 publications

Galactagogue Effect of &lt;i&gt;Euphorbia hirta&lt;/i&gt; (Euphorbiaceae) Aqueous Leaf Extract on Milk Production in Female Wistar Rats

Galactagogue Effect of &lt;i&gt;Euphorbia hirta&lt;/i&gt; (Euphorbiaceae) Aqueous Leaf Extract on Milk Production in Female Wistar Rats

Sensory Analysis and Physicochemical Parameters of Three "TEAS" Formulations Obtained from Aromatic Plant Powders from Côte d’Ivoire

Chemical Composition and Antibacterial Activity of Lippia multiflora Moldenke Essential Oil from Different Regions of Angola

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Product

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Galactagogue Effect of <i>Euphorbia hirta</i> (Euphorbiaceae) Aqueous Leaf Extract on Milk Production in Female Wistar Rats

Galactagogue Effect of <i>Euphorbia hirta</i> (Euphorbiaceae) Aqueous Leaf Extract on Milk Production in Female Wistar Rats