2015
DOI: 10.1007/s12291-015-0527-8
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Hepatoprotective and Nephroprotective Effect of Curcumin Against Copper Toxicity in Rats

Abstract: Curcumin is a natural anti-inflammatory and antioxidant with several potential health benefits. Although it has been examined in several metals toxicity studies, but its role in the protection against copper toxicity has not been investigated. In this study; the detoxification and antioxidant effect of curcumin were examined to determine its prophylactic/therapeutic role experimentally in rats. Forty albino rats were divided into five groups; control, CuSO4 (4 mg/kg body weight), curcumin (80 mg/kg body weight… Show more

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Cited by 57 publications
(45 citation statements)
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“…Histopathologically, the kidneys showed severe tubular necrosis with renal casts and severe interstitial nephritis associated with inflammatory cells infiltration. Similar results were reported by Hashish and Elgaml (2016). The NZn treated rats also, showed a significant increase in serum hepatic enzymes (AST, ALT, ALP and GGT), total and indirect bilirubin with a significant decrease in total protein and albumin.…”
Section: Discussionsupporting
confidence: 88%
See 1 more Smart Citation
“…Histopathologically, the kidneys showed severe tubular necrosis with renal casts and severe interstitial nephritis associated with inflammatory cells infiltration. Similar results were reported by Hashish and Elgaml (2016). The NZn treated rats also, showed a significant increase in serum hepatic enzymes (AST, ALT, ALP and GGT), total and indirect bilirubin with a significant decrease in total protein and albumin.…”
Section: Discussionsupporting
confidence: 88%
“…Cu is a catalyst that leads to induction of oxidative stress and formation of reactive oxygen species (ROS) leading to cellular, DNA and lipid damage. The main target organs for Cu toxicity are liver and kidney leading to hepato-renal toxicity (Hashish and Elgaml, 2016). Zinc (Zn) is an essential metal which plays an important role in several biochemical and cellular functions (Fang et al, 2002) as the stabilization of biological membranes and protecting them from damage , preventing free radical formation, correcting the immunity, replication and transcription of DNA and intercellular signaling (Sandstead et al, 2007 andShah, 2011).…”
Section: Introductionmentioning
confidence: 99%
“…Besides these usages, curcumin exerts promising pharmacological properties, such as anti-oxidant, anticancer, anti-inflammatory and antifibrinolytic effects [3][4][5]. Thus, it has long been believed to be a potential protective natural compound against cardiac diseases, and to possess hepatoprotective and nephroprotective activities [6]. Over the past several decades, extensive research has demonstrated its possible action mechanisms, such as inhibiting experimental allergic encephalomyelitis in the treatment of multicentric sclerosis [7], and as a sarcoplasmic/endoplasmic reticulum calcium pump against cystic fibrosis [8].…”
Section: Introductionmentioning
confidence: 99%
“…Herein, CS‐induced oxidative renal tissue damage by elevating the serum urea, creatinine, and uric acid levels. Hashish and Elgaml detailed the changes in serum urea creatinine levels in rats after CS administration. TM, NTM, or DSM administration successfully decreased the previous levels.…”
Section: Discussionmentioning
confidence: 99%
“…Rats were allowed to acclimatize for 1 week before the experiment commenced, and then they were divided into five groups of 10 each. Group I (untreated control) was injected with carboxymethylcellulose, group II (positive control) was administered CS orally (300 mg/kg), group III (CS+DSM) was administered CS and DSM (100 mg/kg), group IV (TM‐treated) was administered TM 80 mg/kg, and group V (CS+NTM80) was treated with CS and NTM (80 mg/kg). All treatments were administered simultaneously with CS daily for 7 days.…”
Section: Methodsmentioning
confidence: 99%