Hepatoprotective and nephroprotective activity of hydroalcoholic extract of &lt;i&gt;Ipomoea staphylina&lt;/i&gt; leaves

Bag, Anupam Kanti; Mumtaz, Sayeed Mohammed Firdous

doi:10.3329/bjp.v8i3.14845

Cited by 28 publications

(22 citation statements)

References 8 publications

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“…We also find similar types of findings in our previous work (Hussain et al, 2014a,b). The results of our present study are highly in consistent with the findings of several studies that have reported the hepatoprotective effects of different plants including Carica papaya (Sadeque and Begum, 2010), Carissa spinarum (Hegde and Joshi, 2010), Cocculus hirsutus (Thakare et al, 2009), Convolvulus arvensis (Ali et al, 2013), Dodonaea viscosa (Khan et al, 2013), Ipomoea staphylina (Bag and Mumtaz, 2013), Suaeda fruticosa (Rehman et al, 2013), Alcea rosea and Malva sylvestris (Hussain et al, 2014a,b), Trianthema decandra (Balamurugan and Muthusamy, 2008). All of these plants have shown the more or less likely to same hepatoprotective effects against paracetamol-induced hepatotoxicity under different experimental conditions.…”

Section: Discussionsupporting

confidence: 82%

Hepatoprotective effects of Sapium sebiferum in paracetamol-induced liver injury

Hussain

Akash

Tahir

et al. 2015

Bangladesh J Pharmacol

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Sapium sebiferum leaves were used to determine its hepatoprotective effects against paracetamol-induced hepatotoxicity in mice. A dose dependent study was conducted using two different doses (200 mg/kg and 400 mg/kg) of the extract of S. sebiferum against toxic effects of paracetamol (500 mg/kg) in experimental animal model. Silymarin (50 mg/kg) was used as standard drug to compare therapeutic effects of S. sebiferum with control and paracetamol-treated groups. Paracetamol significantly increased the serum levels of liver enzyme markers like alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, total bilirubin, and direct bilirubin. The extract showed protective effects by normalizing the liver enzymes markers in a dose dependent manner. Histopathological results confirmed the hepatoprotective effects of leaves of S. sebiferum. We conclude that leaves of S. sebiferum have strong hepatoprotective effects against paracetamol-induced liver injury and can be used in liver injuries caused by drug-induced toxicity.

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Section: Discussionsupporting

confidence: 82%

Hepatoprotective effects of Sapium sebiferum in paracetamol-induced liver injury

Hussain

Akash

Tahir

et al. 2015

Bangladesh J Pharmacol

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“…So there is an urgent need to investigate the natural plants and isolate their constituents which can be beneficial to control liver diseases (Ravikumar et al, 2012). It has been seen that many herbal plants are found to be hepatoprotective such as Cichorium intybus (Heibatollah et al, 2008), Luminet racemosa (Gnanadesigan et al, 2011), Solanum nigrum (Raju et al, 2003), Hibiscus vitifolius (Samuel et al, 2012), Chenopodium murale (Saleem et al, 2014), Trichodesma sedgwickianum (Saboo et al, 2013), Oflpomoea staphylina (Bag and Mumtaz, 2013), Convolvulus arvensis (Ali et al, 2013), Suaeda fruticosa (Rehman et al, 2013) and Khamira Gaozaban Ambri Jadwar Ood Saleeb Wala .…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective effect of aqeous methanolic extract of Rumex dentatus in paracetamol induced hepatotoxicity in mice

Saleem

Ahmed²,

Karim³

et al. 2014

Bangladesh J Pharmacol

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Rumex dentatus is well known plant of Polygonaceae family which is widely used in traditional medicine to treat gastrointestinal tract. R. dentatus at doses 250 and 500 mg/kg significance decreased (p<0.001) the elevated level of ALT, AST, ALP and bilirubin induced by paracetamol and results are comparable (p<0.001) with silymarin. The results were supported by histopathological investigations, phytochemical screening and detection of hepatoprotective active constituents e.g quercetin, kaempferol, myricetin by HPLC. So, it is concluded that R. dentatus has hepatoprotective effect against paracetamol liver damage in mice. Article InfoReceived:12

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“…Among the plants, Carica papaya (Sadeque and Begum, 2010), Carissa spinarum (Hegde and Joshi, 2010), Cestrum nocturnum , Chenopodium murale , Cocculus hirsutus (Thakare et al, 2009), Convolvulus arvensis (Ali et al, 2013), Dodonaea viscosa , Khamira Gaozaban Ambri Jadwar Ood Saleeb Wala , OfIpomoea staphylina (Bag and Mumtaz, 2013), Suaeda fruticosa (Rehman et al, 2013), Trianthema decandra (Balamurugan and Muthusamy, 2008) and Trichodesma sedgwickianum (Saboo et al, 2013) showed hepatoprotective effect.…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic potential of Conocarpus lancifolius

Saadullah

Chaudary

Uzair

et al. 2014

Bangladesh J Pharmacol

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Hepatoprotective and nephroprotective activity of hydroalcoholic extract of <i>Ipomoea staphylina</i> leaves

Cited by 28 publications

References 8 publications

Hepatoprotective effects of <i>Sapium sebiferum</i> in paracetamol-induced liver injury

Hepatoprotective effects of <i>Sapium sebiferum</i> in paracetamol-induced liver injury

Hepatoprotective effect of aqeous methanolic extract of <i>Rumex dentatus</i> in paracetamol induced hepatotoxicity in mice

Antidiabetic potential of <i>Conocarpus lancifolius</i>

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