Hepatoprotective and free radical scavenging effects of Nelumbo nucifera

Sohn, Dong Hwan; Kim, Y.-C.; Oh, Seon-Hee; Park, E.-J.; Li, X.; Lee, B.-H.

doi:10.1078/094471103321659889

Cited by 143 publications

(114 citation statements)

References 17 publications

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“…Inflammation caused by administration of Fenton mixture resulted in the oxidative stress might be responsible for this increment. Sohn et al (2003) have mentioned that the hepatoprotective effect of Nelumbo nucifera might be due to the antioxidant effect. These earlier references and also the results of our present findings strengthen the result that the decreased level of marker enzymes like GOT and GPT observed in treatment with extract might be due to the antioxidant activity of Nelumbo nucifera.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant activity of Nelumbo nucifera (Gaertn) flowers in isolated perfused rat kidney

Krishnamoorthy¹,

Chellappan²,

Joseph³

et al. 2009

Rev. bras. farmacogn.

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RESUMO: "Atividade antioxidante das flores de Nelumbo nucifera (Gaertn) em rim isolado perfundido de rato". A padronização da indução de estresse oxidativo com a mstura de Fenton em rim isolado perfundido de rato e a avaliação do efeito antioxidante das flores de Nelumbo nucifera em rim isolado de rato oxidativamente estressado são realizadas no presente estudo. Seis grupos de rim isolado perfundido de rato foram utilizados para o presente estudo. O grupo I de rins recebeu veículo. O grupo II de rins foi oxidativamente estressados com a mistura de Fenton. Os grupos III e IV de animais foram tratados com duas doses graduais de extrato após a administração da mistura de Fenton. Os grupos V e VI de rins foram perfundidos com duas doses graduais de extrato sem a mistura de Fenton. A mistura de Fenton causou estresse oxidativo com diferença significativa de malondialdeído (TBARS), glutationa reduzida (GSH), glutationa peroxidase (GPx), catalase, glutamato oxaloacetato transaminase (GOT) e glutamato piruvato transaminase (GPT) (p<0,05) em ratos doentes. No tratamento dos animais com extrato, o estresse oxidativo foi diminuído com aumento nos antioxidantes e as enzimas marcadoras mantiveram o nível normal. Este efeito do extrato foi dependente da dose. Em conclusão, a mistura de Fenton desenvolveu o estresse oxidativo em rim isolado perfundido de rato e o extrato das flores de Nelumbo nucifera apresenta atividade antioxidante no rim isolado perfundido oxidativamente estressado. Unitermos:Nelumbo nucifera, Nymphaceae, mistura de Fenton, malondialdeído, GOT, rim isolado perfundido.ABSTRACT: Standardization of induction of oxidative stress with Fenton mixture in isolated perfused rat kidney and evaluation of antioxidant effect of Nelumbo nucifera flowers in isolated oxidatively stressed rat kidney are carried out in present study. Six groups of isolated perfused rat kidney were used for the present study. Group I kidneys were received vehicle. Group II kidneys were oxidatively stressed with Fenton mixture. Group III and IV animals were treated with two graded doses of extract after the administration of Fenton mixture. Group V and VI kidneys were perfused with two graded doses of extract without Fenton mixture. Fenton mixture was found to cause oxidative stress with significant difference of malondialdehyde (TBARS), Reduced glutathione (GSH), Glutathione peroxidase (GPx), catalase, Glutamate Oxaloacetate Transaminase (GOT) and Glutamate Pyruvate Transaminase (GPT) (p<0.05) in diseased rats. On treating animals with extract, the oxidative stress was decreased with increase in antioxidants and the marker enzymes were found to maintain the normal level. This effect of extract was found to be dose dependent. In conclusion, Fenton mixture developed the oxidative stress in isolated perfused rat kidney and Nelumbo nucifera flowers extract exhibits antioxidant activity in that oxidatively stressed isolated perfused kidney.

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Section: Discussionmentioning

confidence: 99%

Antioxidant activity of Nelumbo nucifera (Gaertn) flowers in isolated perfused rat kidney

Krishnamoorthy¹,

Chellappan²,

Joseph³

et al. 2009

Rev. bras. farmacogn.

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“…Misket üzümü ve yer fıstığında bulunan resveratrol kozmetik bileşeni olarak antioksidan ve cilt koruyucu olarak belirtilmekte 44 , diğer antioksidanlarla karşılaştırıldığı bir çalışmada UV ile artan fotoyaşlanmada matriks metalloproteinazı önemli ölçüde inhibe ederek yaşlanma karşıtı etki gösterdiği ve UVB ışınlarına diğerlerinden daha koruyucu olduğu görülmüştür 53,66,67 .Nelumbo nucifera, serbest radikallere karşı antioksidan etkisinden dolayı anti-aging krem terkibinde bulunan ve mavi lotus olarak bilinen bir bitkidir. Ayrıca in vivo çalışmalar ile obezitiye karşı da etkin olduğu gösterilmiştir 68,69,70 . Üzüm çekirdeğinde (Vitis vinifera-Vitaceae) yüksek oranda (+)-kateşinin bulunmaktadır ve bu yüzden anti-aging kozmetik formülasyonlarda kullanılmaktadır.…”

Section: Bitki Ekstreleri Ve Bileşenleriunclassified

Anti-Aging Cosmetics Approaches and Components in Products

Yapar¹,

Tanrıverdi²

2016

BSBD

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Cilt yaşlanması; iç veya dış faktörlerin veya bunların birlikteliğinin neden olduğu karmaşık biyolojik bir süreçtir. Gelişen üretim teknolojileri, farmasötik taşıyıcı sistemlerin kozmetik formüllerinde kullanılması ve yenilikçi bileşenlere dayalı yeni nesil kozmetik ürünler, temel kozmetik bakımdan ileri alternatifler sunmaktadır. İleri teknoloji kullanılarak üretilen kozmetik aktif bileşenleri, doğal kaynaklı hammaddelerin kozmetik bileşenleri olarak kullanımının artması ve farmasötik taşıyıcı sistemlerin kozmetik formüllerinde kullanılması ile geliştirilen kozmetik ürünler toplumların artan kozmetik beklentilerini karşılamayı hedeflemektedir. Bu derlemede, günümüzde bireylerin dış ve iç faktörler ile artan cilt yaşlanmasının, kozmetik ürün odaklı çözümleri özellikle bileşenler açısından irdelenmiş, yaşlanma karşıtı farklı yaklaşımlar özetlenmiş ve kullanılan taşıyıcı sistemler belirtilmiştir.

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“…The seed of Nelumbo nucifera (Gaertn), also known as the lotus, is traditionally used in Chinese folk medicine. A number of previous studies have reported that the lotus seed exhibits numerous health benefits and pharmacological effects, such as anti-ischemic (11), antioxidant (12)(13)(14), hepatoprotective (12), antiproliferative (15)(16)(17)(18)(19), anti-inflammatory (20), anti-infertility (21), anti-arrhythmic (22)(23)(24)(25)(26), antifibrotic (27) and antiviral (28) activities. In the present study, the anticancer activity of alkaloids extracted from the Ba lotus seed (BLSA), a new variety of Nelumbo nucifera, which only grows in Chongqing, a city located in the southwest of China, was investigated in human NPC CNE-1 cells.…”

Section: Anticancer Activities Of Alkaloids Extracted From the Ba Lotmentioning

confidence: 99%

Anticancer activities of alkaloids extracted from the Ba lotus seed in human nasopharyngeal carcinoma CNE-1 cells

Zhao

Xia

Peng³

et al. 2016

Experimental and Therapeutic Medicine

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Abstract.To investigate the anticancer activities of alkaloids from the Ba lotus seed (BLSA) in human nasopharyngeal carcinoma (NPC) CNE-1 cells, an MTT assay, flow cytometry, reverse transcription-polymerase chain reaction and western blotting were performed. BLSA was found to significantly reduce CNE-1 cell proliferation in a dose-dependent manner at all concentrations compared with the control (P<0.05). In addition, flow cytometry analysis identified that BLSA treatment significantly increased the sub-G1 content in CNE-1 cells (P<0.05). Following BLSA treatment, the mRNA and protein levels of a number of apoptosis-related factors, such as caspase family members (caspase-3, -8 and -9), B-cell lymphoma (Bcl)-2-associated X protein, Fas and Fas ligand were significantly increased compared with the control (P<0.05). This was accompanied by a significant decrease in anti-apoptotic Bcl-2 and Bcl-extra large protein expression compared with the control (P<0.05). Furthermore, BLSA treatment was determined to modulate CNE-1 cell expression of nuclear factor (NF)-κB and NF-κB inhibitor α. The results of the present study indicate that BLSA has anticancer activity through inducing cellular apoptosis. In addition, these results suggest that BLSA can be used as a therapeutic agent in NPC.

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Hepatoprotective and free radical scavenging effects of Nelumbo nucifera

Cited by 143 publications

References 17 publications

Antioxidant activity of Nelumbo nucifera (Gaertn) flowers in isolated perfused rat kidney

Antioxidant activity of Nelumbo nucifera (Gaertn) flowers in isolated perfused rat kidney

Anti-Aging Cosmetics Approaches and Components in Products

Anticancer activities of alkaloids extracted from the Ba lotus seed in human nasopharyngeal carcinoma CNE-1 cells

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