Hepatoprotective and antioxidant effects of <i>Hedera helix</i> extract on acetaminophen induced oxidative stress and hepatotoxicity in mice

Moshaie-Nezhad, Pedram; Maleki, Firouz Faed; Hosseini, Seyed Mohammad; Yahyapour, Mohsen; Iman, Maryam; Khamesipour, Ali

doi:10.1080/10520295.2019.1566569

Cited by 10 publications

(8 citation statements)

References 30 publications

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“…Moreover, although liver MDA levels have raised, GPX, SOD, and CAT activities have reduced in mice. Correspondingly, the prior studies' results are consistent with this result (11,12). .…”

Section: Discussionsupporting

confidence: 82%

Protective effect of Protocatechuic acid on Acetaminophen - induced liver toxicity in mice

Mousavi

Khodayar

Bazle

et al. 2022

Preprint

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Background Acetaminophen (APAP) is known as a safe drug for the relief of fever and pain at therapeutic levels. However, APAP toxicity is considered as the most general cause of acute hepatic damage. This research aimed to evaluate the protective effects of Protocatechuic acid (PCA), as an antioxidant, on the APAP-induced liver toxicity in mice. Methods In this regard, we treated male ICR mice with 40, 80, and 160 mg/kg PCA followed by 300 mg/kg APAP 1 h later for 7 days. By passing 24 h from the APAP administration, they were sacrificed, their Liver was dissected, and blood samples were collected for the evaluation of liver function. Results The results show that APAP-overdose (300mg/kg, IP) could lead to acute liver injury in mice, which is characterized by a rise in serum liver function tests (AST, ALT), pathological changes, and a decline in the antioxidant defense system. In addition, hepatic MDA levels, as the end product of lipid peroxidation, have increased, while the antioxidant enzymes such as GPX, SOD, and CAT activities have decreased in mice. In contrast, it was shown that pre-treatment with PCA could decline MDA, ALT, and AST levels and obviously attenuate the liver histological damage and the antioxidant enzymes. Finally, the results show that PCA had protective effects on the APAP-induced liver damage in mice. Conclusions Our studies show that hepatoprotective natural agents can be effective in APAP -liver toxicity.

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“…Moreover, although liver MDA levels have raised, GPX, SOD, and CAT activities have reduced in mice. Correspondingly, the prior studies' results are consistent with this result (11,12). .…”

Section: Discussionsupporting

confidence: 82%

Protective effect of Protocatechuic acid on Acetaminophen - induced liver toxicity in mice

Mousavi

Khodayar

Bazle

et al. 2022

Preprint

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“…In our previous study, we have investigated the antioxidant properties of ivy leaf extract against acetaminophen induced oxidative damage and hepatotoxicity in mice. Administration of ivy extract at doses of 200 mg/kg was able to protect the liver against toxicity (5).…”

Section: Discussionmentioning

confidence: 95%

“…Hedera helix, also known as Ivy is an evergreen plant which belongs to Araliaceous family with small, heartshaped leaves. It is common in most parts of the world particularly in East Asia, India, and America (4,5). The ivy leaf extracts is used as anti-inflammatory, anti-cough, anti-neurologic pain, anti-rheumatism, antifungal, antiworm, anti-spasm, and anti-asthma (4,6).…”

Section: Paracetamolmentioning

confidence: 99%

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Protective effect of ivy leaf extract on paracetamol-induced oxidative stress and nephrotoxicity in mice

Moshaei-Nezhad¹,

Hosseini²,

Yahyapour³

et al. 2019

J Herbmed Pharmacol

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“…A key role in the total biological activity of saponins is played by α-hederin and hederacoside B and C [Wolf et al 2009, Hussien and Awad 2014, Yu et al 2016, Shawky and El Sohafy 2020. The following phenolic compounds have been identified as well rutin, kaempferol 3-O-rutinoside, quercetin 3-O-glucoside, kaempferol 3-O-glucoside, quercetin, kaempferol, chlorogenic acid, neochlorogenic acid, 3,5-dicaffeoylquinic acid, rosmarinic acid, caffeic, protocatechuic acid , Bezruk et al 2020b, Shawky and El Sohafy 2020, a coumarin compound scopolin [Moshaie-Nezhad et al 2019], and sterols: stigmasterol, campesterol, and spinasterol .…”

Section: Introductionmentioning

confidence: 99%

Biologically active compounds of plant origin in medicine

Chwil¹,

Skoczylas²

2021

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Hepatoprotective and antioxidant effects of Hedera helix extract on acetaminophen induced oxidative stress and hepatotoxicity in mice

Cited by 10 publications

References 30 publications

Protective effect of Protocatechuic acid on Acetaminophen - induced liver toxicity in mice

Protective effect of Protocatechuic acid on Acetaminophen - induced liver toxicity in mice

Protective effect of ivy leaf extract on paracetamol-induced oxidative stress and nephrotoxicity in mice

Biologically active compounds of plant origin in medicine

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