Hepatoprotective and antioxidant activity of meadowsweet extract during experimental toxic hepatitis

Abstract

The extract of meadowsweet aerial parts exhibits hepatoprotective and antioxidant activity during experimental toxic CCl 4 hepatitis. This extract improved liver function. Meadowsweet extract in 70% ethanol (100 mg/kg) was most potent and exhibited low toxicity. By several parameters the effectiveness of this extract surpassed that of Carsil.Liver and biliary diseases occupy an important place in the overall morbidity [4][5][6]. Despite the existence of numerous potential sources for hepatoprotectors, there are only small number of drugs of this group. They exhibit therapeutic efficacy only after longterm treatment, which is often associated with side effects. In Russia, much attention is paid to the search and synthesis of highly effective and safe hepatoprotectors.The pathogenesis of liver damage induced by various hepatoprotectors is mainly determined by prooxidant activity of these drugs. Plant antioxidants are promising hepatoprotective agents. The therapeutic effect of these agents under conditions of toxic liver injury is primarily related to the presence of phenol compounds (e.g., flavonoids, coumarins, and phenol carbonic acids). They have a wide range of biological activity, including antioxidant, membrane-stabilizing, antitoxic, and reparative properties [2,4,8].Meadowsweet (Filipendula ulmaria (L.) Maxim.) of the Rosaceae family holds much promise in this respect. This plant contains various phenol compounds and is extensively used in traditional medicine for the treatment of digestive diseases [1].Here we studied hepatoprotective and antioxidant activity of the extract from meadowsweet aerial parts (ME) during experimental toxic hepatitis. MATERIALS AND METHODSExperiments were performed on 112 male outbred albino rats weighing 220-240 g. The animals were kept in a vivarium under standard conditions and fed a standard diet. ME was obtained by treatment of meadowsweet aerial parts with solvents (water; 40, 70, and 95% ethanol) at 80-85 o C for 2 h. The raw material/extracting agent ratio was 1:10. ME in 70% ethanol consists of various substances that are extracted from ground raw materials with 70% ethanol. The extract contains 3.93% flavonoids by the content of quercetin and its glycosides (dry residue >22%). Meadowsweet aerial parts contain simple phenols, flavonoids, organic acids, coumarins, tannins, saponins, polysaccharides, carotenoids, amino acids, macroelements, and trace elements. Toxic hepatitis was modeled by daily intragastric administration of 1 ml/kg CCl 4 in 20% oil solution for 6 days. Toxic hepatitis in rats was verified by aminotransferase activity and contents of bilirubin and its fractions. The suspension of ME in 1% starch gel

In vitro and in vivo assessment of the genotoxicity and antigenotoxicity of the Filipendula hexapetala and Filipendula ulmaria methanol extracts

“…High level of phenolic compounds in F. ulmaria and F. hexapetala induce potent antioxidant and antimicrobial activities (Barros et al, 2011;Katanić et al, 2015a;Katanić et al, 2015b). Based upon the existing literature, these two Filipendula species possess a broad spectrum of biological activities like hepatoprotective (Shilova et al, 2006;Ćebović and Maksimović, 2012), antiulcerogenic (Vasiliauskas et al, 2004) and anti-inflammatory activity (Vogl et al, 2013).…”

Антиоксидантные Свойства Растительных Сборов, Улучшающих Когнитивно-Мнестические Функции

“…Îêèñëèòåëüíûé ñòðåññ, âûçûâàåìûé ãèïîêñè÷åñêèì âîçäåéñòâèåì, çàïóñêàåò ïðîöåññû ÏÎË â òêàíÿõ ìîçãà, ÷òî ïðîÿâëÿåòñÿ â óâåëè÷åíèè ñîäåðaeàíèÿ ÒÁÊ-ÐÏ è êîìïåíñàòîðíî-àäàïòèâíîì ïîâûøåíèè àêòèâíîñòè àíòèîêñèäàíòíûõ ñèñòåì ëèïèäíûõ ñòðóêòóð êëåòêè [2,5,6,10,14,15].  ýêñïåðèìåíòå ñáîð I ñíèaeàåò ñîäåðaeàíèå ÒÁÊ-ÐÏ, ïðîÿâëÿÿ, òàêèì îáðàçîì, àíòèîêñèäàíòíûå ñâîéñòâà.…”

“…Äàííûé ôàêò ìîaeíî îáúÿñíèòü íàëè÷èåì â ñîñòàâå ýòîãî ñáîðà ÀÎ, ñõîäíûõ ñ ýíäîãåííûìè ÀÎ aeèâîòíûõ, ÷òî ïî ìåõàíèçìó îòðèöàòåëüíîé îáðàòíîé ñâÿçè èíãèáèðóåò ñîáñòâåííûå àíòèîêñèäàíòíûå ñèñòåìû [2,6,15,16].  ýêñïåðèìåíòå ðàñòèòåëüíûå ÀÎ áîëåå óñïåøíî ñäåðaeèâàþò íàêîïëåíèå ÒÁÊ-ÐÏ [5,6,15,16], ÷åì ñîáñòâåííûå àíòèîêñèäàíòíûå ñèñòåìû aeèâîòíûõ, ÷òî ïðåäñòàâëÿåòñÿ íàãëÿäíûì ïðè ñðàâíåíèè ñ ãðóïïîé ãèïîêñè÷åñêîãî êîíòðîëÿ. Ôåíîëüíûå ñîåäèíåíèÿ, èìåÿ ãèäðîêñèëû ñ ïîäâèaeíûìè àòîìàìè âîäîðîäà, íåéòðàëèçóþò ãèäðîïåðåêèñè ïîëèåíîâûõ aeèðíûõ êèñëîò, ïðåâðàùàÿ èõ â íåòîêñè÷íûå ãèäðîêñèêèñëîòû [6,15,16].…”

Medicinal plants

“…Keeping in mind the significant content of flavonoids in the extract of the aerial part of F. ulmaria, the majority of which is filimarin, it can be assumed that the latter is responsible for the pharmacological activity of the extract, in particular, the hepatoprotective activity [7,8]. …”