Hepatoprotective activity of Punica granatum leaf extract against Carbon Tetrachloride induced Hepatotoxicity in Rats

Kumar, M.; Dandapat, Sukumar; Sinha, Manoranjan

doi:10.12680/balneo.2018.166

Cited by 14 publications

(10 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has antioxidant properties ( Dhuley, 1999) and hepatoprotective properties ( Kumar et al,2015). It stimulates contraction of uterine muscle and facilitates child birth.…”

Section: Adhotoda Vasica Is Well Known Plant Drug In Ayurvedic Andmentioning

confidence: 99%

Protective Effect of Adhatoda Vasica Extract on Gamma Radiation Induced Oxidative Stress in Mice Biceps Muscle

2017

IJSR

View full text Add to dashboard Cite

In the era of expanding energy program all over the world, the role of radiationbiology has acquired greater relevance and significance in addressing the health issues. In present time, nuclear terrorism and weapons related effects are raising much alarm and concern to public health. Radiation is often used to treat malignant tumours, or in combination with surgery. Ionizing radiation is known to produce deleterious effects on living organisms. Despite the advantage of radiotherapy and improvements in techniques, many patients experience moderate to severe side effects including xerostomia, diarrhea, mucositis, dermatitis, ulceration and fibrosis . Reactive oxygen species (ROS) such as hydroxyl radical (OH),superoxide anion radicals (O2) and hydrogen peroxide(H2O2) were produced as a response to ionizing radiation Mammalian cells are equipped with both enzymatic and non-enzymatic antioxidant mechanisms to minimize cellular damage resulting from interaction between cellular constituents and ROS. Under normal conditions, a delicate balance exists between the generation of ROS and the cellular antioxidant systems. Over production of ROS in both intra and extra-cellular spaces upon exposure of cells to ionizingradiation results in oxidative stress due to the imbalance between pro-oxidants and antioxidants. The objective of the present study was to evaluate the antioxidant enzyme activities (Superoxide dismutase , Catalase and lipid peroxidation ) in biceps muscle of mice. Mice were divided into 4 groups. Study was performed at 7, 14, 21 and 28 days stage. Present study convincingly demonstrated that Adhatoda extract provides protection against free radical damage.

show abstract

“…It has antioxidant properties ( Dhuley, 1999) and hepatoprotective properties ( Kumar et al,2015). It stimulates contraction of uterine muscle and facilitates child birth.…”

Section: Adhotoda Vasica Is Well Known Plant Drug In Ayurvedic Andmentioning

confidence: 99%

Protective Effect of Adhatoda Vasica Extract on Gamma Radiation Induced Oxidative Stress in Mice Biceps Muscle

2017

IJSR

View full text Add to dashboard Cite

show abstract

“…The plant contains the following chemical constituents; cyprotene, acopaene, cyperene, aselinene, rotundene, valencene, cyperol, gurjunene, trans-calamenene, dcadinene, gcalacorene, cadalene, amuurolene, gmuurolene, cyperotundone, mustakone, isocyperol, acyperone [6] and 4, 11-selinnadien-3-one and 1,8-cineole [7]. The oil of C. rotundus was primarily composed of cyperol, α-cyperene, rotundine, α-cyperone, α-copaene, valerenal, myrtenol, βpinene, α-pinene and α-Selinene, sesquiterpene hydrocarbons (Caryophyllene) [8]. According to the Ayurveda, C. rotundus rhizomes are considered astringent, diaphoretic, diuretic, analgesic, antispasmodic, aromatic, carminative, antitussive, emmenagogue, litholytic, sedative, stimulant, stomachic, vermifuge, tonic and antibacterial [9].…”

Section: Introductionmentioning

confidence: 99%

Histopathological Study and Oxidative Stress, Antioxidants Parameters and Liver Enzymes Activity Determination of <i>Cyperus</i> Methanolic Extract and Glucophage Drug on Albino Male Mice

Al-Ezzy¹,

Soud²,

Sadoon³

2019

BIO

View full text Add to dashboard Cite

The study aimed to explain the hepatoprotective action of Cyperus rotundus methanolic extract in vitro and in vivo (albino male mice). An interaction between the extract and Glucophage drug were also made to evaluate the in vivo modulating effects of the extract. The hepatoprotective evaluations included assessment of malondialdyde (MDA) and catalase (CAT) activities and liver function enzymes (aspartate aminotransferase; AST and alanine aminotransferase; ALT and alkaline phosphatase; ALP) in blood serum, as well as histopathological estimation of liver tissue, in mice after administration of the drug Glucophage and cyperus rotundus methanolic extract alone or with interaction. The results indicated that the plant extract (200mg/kg) decreased MDA activity and increase significantly activity of catalase in comparison to positive and negative controls. Also Cyperus rotundus methanolic increase the level of ALT, AST and ALP. The drug Glucophage was contributed to increased MDA activity and decreased the activity of catalase in comparison to positive and negative controls in addition to increase the activity of ALT, AST and ALP. The interaction between the extract and glucophage increased both MDA and catalase activity in comparison to control group. In addition to increase the liver function enzymes ALT, AST and ALP. The histopathological activity represented that histopathological section in the liver of mouse treated with Cyperus rotundus extraction showed scattered degenerated cells while histopathological section in the liver of mouse treated with Glucophage showed normal architecture with few pyknotic nuclei. Histopathological section in the liver of mouse treated with Cyperus rotundus and Glucophage showed multiple aggregation mononuclear cells around central vein.

show abstract

“…It is used in different treatment systems such as Ayurveda, Unani, Siddha, Homeopathy, and Allopathy [11]. This plant possesses antiinflammatory, antioxidant, hepatoprotective, neuroprotective, and cardioprotective functions which can be attributed to their therapeutic potential [12][13][14][15]. Various therapeutic uses have been reported, VN leaf extract is used as an external application for treatment of mumps, wounds, and cuts.…”

Section: Introductionmentioning

confidence: 99%

Vitex Negundo Extracts Protect Human Corneal Epithelial Cells From Ultraviolet C-Induced Phototoxicity

Deeksha

Arunachalam

2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: The objective of the study was to investigate the protective effects of Vitex negundo (VN) extracts against ultraviolet (UV) light C-induced oxidative stress in human corneal epithelial cells (HCEC) in vitro. Methods: The VN extracts were checked for their antioxidant activities by biochemical tests. The preliminary phytochemical analysis was done to check the presence of secondary metabolites. To trigger oxidative stress, the HCEC were exposed to UVC irradiation (200 J/m2). Then, different concentration of VN extracts was administered after 1 h of UVC irradiation. The effects of UVC irradiation and the extracts on the HCEC viability, morphology, cell migration by scratch assay, and reactive oxygen species (ROS) production by dichlorofluorescein diacetate method were measured. Results: VN ethanol (VNE) extract showed the highest antioxidant activity than the aqueous extract. Phytochemical screening shows the presence of alkaloids, carbohydrates, proteins, phenolics, and tannins. The extracts showed no cytotoxicity on the HCEC and also the VNE extract did not alter the morphology of the cells. Results suggest that the VNE extract enhanced the proliferation and migration of HCEC. The VNE extract significantly decreased UVC-induced oxidative toxicity by inhibiting the intracellular ROS production and maintained cell viability. Conclusion: VN extracts with its strong antioxidant potential protects HCEC from UVC-induced oxidative stress. The results suggest that these extracts can be used as prophylactic agents or as a therapeutic agent in overcoming UV light-induced damage in various ocular surface diseases such as pterygium and photokeratitis.

show abstract

Hepatoprotective activity of Punica granatum leaf extract against Carbon Tetrachloride induced Hepatotoxicity in Rats

Cited by 14 publications

References 6 publications

Protective Effect of Adhatoda Vasica Extract on Gamma Radiation Induced Oxidative Stress in Mice Biceps Muscle

Protective Effect of Adhatoda Vasica Extract on Gamma Radiation Induced Oxidative Stress in Mice Biceps Muscle

Histopathological Study and Oxidative Stress, Antioxidants Parameters and Liver Enzymes Activity Determination of <i>Cyperus</i> Methanolic Extract and Glucophage Drug on Albino Male Mice

Vitex Negundo Extracts Protect Human Corneal Epithelial Cells From Ultraviolet C-Induced Phototoxicity

Contact Info

Product

Resources

About

Hepatoprotective activity of Punica granatum leaf extract against Carbon Tetrachloride induced Hepatotoxicity in Rats

Cited by 14 publications

References 6 publications

Protective Effect of Adhatoda Vasica Extract on Gamma Radiation Induced Oxidative Stress in Mice Biceps Muscle

Protective Effect of Adhatoda Vasica Extract on Gamma Radiation Induced Oxidative Stress in Mice Biceps Muscle

Histopathological Study and Oxidative Stress, Antioxidants Parameters and Liver Enzymes Activity Determination of &lt;i&gt;Cyperus&lt;/i&gt; Methanolic Extract and Glucophage Drug on Albino Male Mice

Vitex Negundo Extracts Protect Human Corneal Epithelial Cells From Ultraviolet C-Induced Phototoxicity

Contact Info

Product

Resources

About

Histopathological Study and Oxidative Stress, Antioxidants Parameters and Liver Enzymes Activity Determination of <i>Cyperus</i> Methanolic Extract and Glucophage Drug on Albino Male Mice