Hepatoprotective activity of<i>Cyperus alternifolius</i>on carbon tetrachloride–induced hepatotoxicity in rats

Awaad, Amani S.; Soliman, Gamal A.; El-Sayed, Dalia F.; El-Gindi, Omimah D.; Alqasoumi, Saleh I.

doi:10.3109/13880209.2011.580351

Cited by 19 publications

(15 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A variety of crude plant extracts has been also reported to show hepatoprotective activity and may be useful in the treatment of various liver diseases with different etiology [54,55]. In the present study, we have demonstrated DNAprotective effects of lavender oil against two oxidative agents (H 2 O 2 and tBHP) in in vitro and ex vivo conditions, i.e.…”

Section: Discussionsupporting

confidence: 62%

Antioxidant potential of essential oil from Lavandula angustifolia in in vitro and ex vivo cultured liver cells

Kozics¹,

Srančíková²,

Sedláčková³

et al. 2017

neo

View full text Add to dashboard Cite

Lavender is a commonly used herb in traditional medicine in Asia and Europe. It has been reported to be an effective medical plant in treating inflammation, depression and stress, thanks to its sedative and anxiolytic action, thrombotic, and antimicrobial properties. In the present study we investigated the protective effects of essential oil from Lavandula angustifolia (LO) against hydrogen peroxide and tert-butyl hydroperoxide -induced DNA damage. Also the effects of LO on the levels of enzymatic and non-enzymatic antioxidants (SOD-superoxide dismutase, GPx-glutathione peroxidase, GSH-glutathione) were evaluated in in vitro (human hepatoma cell line HepG2) and in ex vivo (freshly isolated rat hepatocytes) systems. The results showed that the oxidant-induced DNA lesions were significantly reduced in both systems pre-treated with the Lavandula angustifolia. The observed DNA-protective activity could be explained by both elevation of GPx activity in cells pre-treated with LO and antioxidant activity of LO.

show abstract

Section: Discussionsupporting

confidence: 62%

Antioxidant potential of essential oil from Lavandula angustifolia in in vitro and ex vivo cultured liver cells

Kozics¹,

Srančíková²,

Sedláčková³

et al. 2017

neo

View full text Add to dashboard Cite

show abstract

“…Numerous studies have reported that intoxication with CCl 4 produce hepatic damage illustrated by increased levels of diagnostic markers such as ALT, AST ALP and bilirubin (total and direct) (Awaad et al. 2012 ; Joseph et al. 2014 ).…”

Section: Discussionmentioning

confidence: 99%

The novel role of β-aescin in attenuating CCl ₄ -induced hepatotoxicity in rats

Singh

Sidhu

Chopra³

et al. 2017

Pharmaceutical Biology

View full text Add to dashboard Cite

Context: β-Aescin has anti-inflammatory, anti-oxidant and antiedematous properties.Objective: The present study investigated the hepatoprotective effect and underlying mechanisms of β-aescin in CCl4-induced liver damage.Materials and methods: Thirty-five Wistar rats were divided into six groups: normal control, CCl4 control, silymarin (50 mg/kg, p.o) and β-aescin (0.9, 1.8 and 3.6 mg/kg, i.p.) treatment for 14 d. CCl4 (1 mL/kg, i.p. for 3 d) was administered to produce hepatic damage. Ponderal changes and liver marker enzymes were estimated. Hepatic oxidative and nitrosative stress was estimated by levels of thiobarbituric acid reactive substances (TBARS), glutathione (GSH) and nitrite/nitrate. Serum TGF-β1 and TNF-α were estimated by ELISA technique. Hepatic collagen and histopathological studies were carried out.Results: β-Aescin (3.6 mg/kg) markedly decreased CCl4-induced increased levels of ALT, AST, ALP (71.77 versus 206.7, 71.39 versus 171.82, 121.20 versus 259 IU/L, respectively), total bilirubin (0.41 versus 1.35 mg/dL), TBARS (2.0 versus 8.83 nmol MDA/mg protein), nitrite/nitrate (352.50 versus 745.15 μg/mL) and increased CCl4-induced decreased GSH levels (0.095 versus 0.048 μmol/mg protein). β-Aescin (3.6 mg/kg) induced focal regenerative changes in liver and markedly decreased TBARS (2.0 versus 8.83 nmol MDA/mg protein), nitrite/nitrate (352.50 versus 745.15 μg/mL), TGF-β1 (92.28 versus 152.1 pg/mL), collagen content (110.75 versus 301.74 μmol/100 mg tissue) and TNF-α (92.82 versus 170.56 pg/mL) when compared with CCl4 control.Discussion and conclusion: The findings suggest that β-aescin has a protective effect on CCl4-induced liver injury, exhibited via its anti-inflammatory, antioxidative, antinitrosative and antifibrotic properties inducing repair regeneration of liver. Hence, it can be used as a promising hepatoprotective agent.

show abstract

“…The etiology of liver diseases is diverse; a variety of crude plant extracts has been reported to show hepatoprotective activity and may be useful in the treatment of these diseases (Awaad et al, 2012;Tatiya et al, 2012). The use of natural plant products having bioactive components promoted growing interest from pharmaceutical industries (Capecka et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective potential of Lavandula coronopifolia extracts against ethanol induced oxidative stress-mediated cytotoxicity in HepG2 cells

et al. 2013

View full text Add to dashboard Cite

The present investigations were carried out to study the protective potential of four extracts (namely petroleum ether extract (LCR), chloroform extract (LCM), ethyl acetate extract (LCE), and alcoholic extract (LCL)) of Lavandula coronopifolia on oxidative stress-mediated cell death induced by ethanol, a known hepatotoxin in human hapatocellular carcinoma (HepG2) cells. Cells were pretreated with LCR, LCM, LCE, and LCL extracts (10-50 μg/ml) of L. coronopifolia for 24 h and then ethanol was added and incubated further for 24 h. After the exposure, cell viability using (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and neutral red uptake assays and morphological changes in HepG2 cells were studied. Pretreatment with various extracts of L. coronpifolia was found to be significantly effective in countering the cytotoxic responses of ethanol. Antioxidant properties of these L. coronopifolia extracts against reactive oxygen species (ROS) generation, lipid peroxidation (LPO), and glutathione (GSH) levels induced by ethanol were investigated. Results show that pretreatment with these extracts for 24 h significantly inhibited ROS generation and LPO induced and increased the GSH levels reduced by ethanol. The data from the study suggests that LCR, LCM, LCE, and LCL extracts of L. coronopifolia showed hepatoprotective activity against ethanol-induced damage in HepG2 cells. However, a comparative study revealed that the LCE extract was found to be the most effective and LCL the least effective. The hepatoprotective effects observed in the study could be associated with the antioxidant properties of these extracts of L. coronopifolia.

show abstract

Hepatoprotective activity ofCyperus alternifoliuson carbon tetrachloride–induced hepatotoxicity in rats

Abstract: (2012) Hepatoprotective activity of Cyperus alternifolius on carbon tetrachloride-induced hepatotoxicity in rats, Pharmaceutical Biology, 50:2, 155-161,

Cited by 19 publications

References 26 publications

Antioxidant potential of essential oil from Lavandula angustifolia in in vitro and ex vivo cultured liver cells

Antioxidant potential of essential oil from Lavandula angustifolia in in vitro and ex vivo cultured liver cells

The novel role of β-aescin in attenuating CCl ₄ -induced hepatotoxicity in rats

Hepatoprotective potential of Lavandula coronopifolia extracts against ethanol induced oxidative stress-mediated cytotoxicity in HepG2 cells

Contact Info

Product

Resources

About

Hepatoprotective activity ofCyperus alternifoliuson carbon tetrachloride–induced hepatotoxicity in rats

Abstract: (2012) Hepatoprotective activity of Cyperus alternifolius on carbon tetrachloride-induced hepatotoxicity in rats, Pharmaceutical Biology, 50:2, 155-161,

Cited by 19 publications

References 26 publications

Antioxidant potential of essential oil from Lavandula angustifolia in in vitro and ex vivo cultured liver cells

Antioxidant potential of essential oil from Lavandula angustifolia in in vitro and ex vivo cultured liver cells

The novel role of β-aescin in attenuating CCl 4 -induced hepatotoxicity in rats

Hepatoprotective potential of Lavandula coronopifolia extracts against ethanol induced oxidative stress-mediated cytotoxicity in HepG2 cells

Contact Info

Product

Resources

About

The novel role of β-aescin in attenuating CCl ₄ -induced hepatotoxicity in rats