Hepatoprotective activity of Hepax–A polyherbal formulation

Devaraj, VC; Krishna, Burdipad G; Viswanatha, Gollapalle Lakshminarayanashastry; Kamath, Jagadish V; Kumar, Sanjay

doi:10.1016/s2221-1691(11)60013-0

Cited by 37 publications

(12 citation statements)

References 11 publications

(8 reference statements)

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“…20 Several studies revealed that CCl4 treatment increased levels of AST, ALT, ALP and bilirubin. [21][22][23][24][25][26] Similarly, in present study there was significant rise of ALT, AST, ALP and bilirubin levels in the CCl4 treated groups signifying the induced liver injury. The co-treatment of CCl4 with silymarin, and also with AEMP reduced liver enzymes and bilirubin (Table 1 and 2).…”

Section: Discussionsupporting

confidence: 57%

Hepatoprotective effect of aqueous extract of Melothria perpusilla against carbon tetrachloride induced liver injury in albino rats

et al. 2017

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Background: In absence of reliable hepatoprotective drug in modern medicine, the traditional herbal medicines have been emphasized. Present study was designed to assess hepatoprotective effect of aqueous extract of Melothria perpusilla (AEMP) against carbon tetrachloride (CCl4) induced liver injury.Methods: Five groups of animals with 6 rats in each were treated for 7 days. Group I received 1% gum acacia in distilled water (1 ml/200 g p.o.) daily. Group II, III, IV and V received CCl4 in liquid paraffin (1 ml/kg s.c.) on day 2, 4 and 6. Group III, IV and V were treated respectively with silymarin (100 mg/kg p.o.), AEMP- 200 and 400 mg/kg p.o. daily. On day 8, liver injury was assessed by measuring serum ALT, AST, ALP and bilirubin.Results: ALT, AST, ALP and bilirubin were significantly reduced in groups receiving both CCl4 and AEMP when compared with CCl4 treated group.Conclusions: AEMP produced hepatoprotective effect against CCl4 induced liver injury.

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Section: Discussionsupporting

confidence: 57%

Hepatoprotective effect of aqueous extract of Melothria perpusilla against carbon tetrachloride induced liver injury in albino rats

et al. 2017

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“…in sucrose solution (40% v/v) in three divided doses. 48 hrs after paracetamol administration, body weight was documented and blood samples were collected for the estimation of biochemical parameters, namely, SGPT, SGOT, ALP and total bilirubin (Devaraj et al, 2011). All the animals were sacrificed and the liver weight was recorded.…”

Section: Paracetamol Induced Hepatotoxicitymentioning

confidence: 99%

Hepatoprotective effect of Poly herbal formulation containing indigenous medicinal plants against various hepatotoxic agents in rats

Sreshta¹,

Babu²

2018

Asian J Pharm Pharmacol

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Objective: To evaluate the protective effect of PHF, a polyherbal formulation, against two experimentally induced hepatotoxicity models in rats. : Hepatoprotective activity of the PHF containing two Materials and methods indigenous medicinal plants extracts and , was screened against CCl and Tinospora cordifolia Curculigo orchioides 4 paracetamol induced hepatotoxicity in rats. : Administration of hepatotoxins (CCl and paracetamol) shows Results 4 significant morphological, biochemical and histopathological deteriorations in the liver of experimental animals. Pretreatment with PHF had significant protection against hepatic damage by maintaining the morphological parameters within normal range and normalizing the elevated levels of biochemical parameters (SGPT, SGOT, ALP and total bilirubin), which were evidently showed in histopathological study. The PHF has highly Conclusions: significant hepatoprotective effect at 200 and 400 mg/kg, p.o. on the liver of all the two experimental animal models. The liver protection due to combined action of all plant extracts along with their phytoconstituents.

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“…of family Asclepiadaceae is a perennial shrub and widely distributed in tropical and subtropical region and most abundant in Bangladesh, India, Burma and Pakistan. [7][8][9][10] The root, stem, leaves, flower and latex of C. gigantea are reported to be utilized in traditional medicine for the treatment of toothache, ear ache, eczema, syphilis, elephantiasis, injury, pain, ulceration, epilepsy, anxiety and mental disorders. 11,12 Traditionally, the root of Calotropis gigantea is used in treatment of leprosy, asthma, bronchitis, and as an expectorant.…”

Section: Introductionmentioning

confidence: 99%

Sub-Acute Toxicity Study of Calotropis gigantea Latex Extracts in Male Swiss Albino Mice

Sanyal¹,

Maity²,

Pradhan³

et al. 2016

Toxicol Forensic Med Open J

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Hepatoprotective activity of Hepax–A polyherbal formulation

Cited by 37 publications

References 11 publications

Hepatoprotective effect of aqueous extract of Melothria perpusilla against carbon tetrachloride induced liver injury in albino rats

Hepatoprotective effect of aqueous extract of Melothria perpusilla against carbon tetrachloride induced liver injury in albino rats

Hepatoprotective effect of Poly herbal formulation containing indigenous medicinal plants against various hepatotoxic agents in rats

Sub-Acute Toxicity Study of Calotropis gigantea Latex Extracts in Male Swiss Albino Mice

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