Hepatoprotective activity of fractions of Fumeria parviflora in Anti tubercular drug induced toxicity in rats

Fumaria parviflora improves liver damage and lipid profile changes in STZ-induced diabetic rats

“…By an injury to the hepatocytes, the leakage of transaminases, bilirubin and ALP is initiated. However, the use of Fumaria parviflora is quite safe at the applied doses and no signs of toxicity or adverse effects were reported in the treated animals (Alqasoumi et al, 2009;Rizvi et al, 2017).…”

“…They conducted that the positive effects of Fumaria parviflora probably is due to the high amounts of antioxidants like flavonoids (Roghani, 2014). Phytochemical experiments on Fumaria parviflora have shown that this plant is rich in phenolic and alkaloids compounds, which have been reported that these compounds have antioxidant activities because they could reduce several mediators of inflammation such as IL-1, IL-6, TNF-α, nitric oxide and prostaglandins (Rizvi et al, 2017). Also, flavonoids, as one of the main components in Fumaria parviflora, are involved in preventing the production of prostaglandins in inflammatory reactions (Rizvi et al, 2017).…”

“…Administration of methanolic extract of Fumaria parviflora decreased the level of blood glucose in diabetic rats (Fathiazad et al, 2013). Treatment with Fumaria parviflora could also reduce the levels of malondialdehyde (MDA), TNF-α, IL-6 and IL-1 in rats, in which inflammation was induced by aspirin (Rizvi et al, 2017). Although in traditional Iranian medicine Fumaria parviflora had been used as a source for the treatment of liver and bile ducts disorders, recent studies reported that it could affect the lipid profile (decrease the levels of LDL, triglycerides [TG] and cholesterol and increase HDL level), blood glucose and liver enzymes in diabetic patients (Al-Snafi, 2018;Osadebe et al, 2014).…”

A Review on Cytomorphological, Medicinal, Phytochemical and Pharmacological Potential of Common Weed of Wheat Crop of Himachal Pradesh: Fumaria Parviflora

“…Such compounds are thought to contribute to mitigating Plant Health Archives 2024, 2(1): 26-30 liver damage, possibly by counteracting oxidative stress and supporting liver function. These findings suggest promising avenues for exploring Fumaria species as natural remedies for liver-related disorders (Rizvi et al, 2017b).…”