Hepatoprotective Activity and Mechanisms of Prenylated Stilbenoids

Abstract

Dietary prenylated stilbenoids, found in various food sources, offer multiple health benefits, including liver protection. However, the underlying mechanisms of hepatoprotection remain unclear. In this study, we synthesized 13 natural prenylated stilbenoids and examined their hepatoprotective activities, with silent mating type information regulation 2 homologue-1 (SIRT1) as the primary target for screening. Among all of the prenylated stilbenoids tested, 4-C-geranyl oxyresveratrol demonstrated superior performance. It activated SIRT1 activity more effectively than resveratrol, a well-known SIRT1 activator. To further investigate the mechanism of liver protection, two in vitro models were used: the palmitic acid-induced lipid accumulation model and the H 2 O 2induced apoptosis model. Our findings suggested that 4-C-geranyl oxyresveratrol mitigated lipid accumulation through the SIRT1-PGC1α pathway, reduced apoptosis via the SIRT1-p53-p21 pathway, and exerted antioxidant effects through the SIRT1-Nrf2 pathway. These findings provide new insights into the chemical basis of the health benefits of prenylated stilbenoids and their potential use as functional food additives.

Focusing on New Discoveries in Food Technology and Creating a New Future of Nutrition and Health: An Introduction to the 4th International Symposium of Food Science, Nutrition and Health in Dalian, China

“…For instance, Dr. Xiaoyang Liu provided insights into food-derived iron supplements derived from oyster protein hydrolysates, particularly the preparation of oyster protein hydrolysate–iron complexes and their in vivo protective effects against iron deficiency in mice . Additionally, papers covered the potential inhibitory effects of rosemary ( R. officinalis L.) extract on SARS-CoV-2 spike protein–ACE2 binding and ACE-2 availability (Dr. Liangli Lucy Yu), the natural prenylated stilbenoids and their hepatoprotective activities with silent mating type information regulation 2 homologue-1 (SIRT1) (Dr. Bao Yang), and the role of medicinal food homology ingredients in regulating macrophage polarization (Dr. Ying Liang) . This section reveals the importance of functional ingredients on human health and may promote the high-quality development of the nutrition and health food industry.…”