Hepatoprotección antioxidante de la cáscara y semilla de Vitis vinifera L. (uva)

Sandoval, Miguel; Lazarte, Karen; Arnao, Inés

doi:10.15381/anales.v69i4.1125

Cited by 8 publications

(8 citation statements)

References 22 publications

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“…Esta citoprotección se debe en gran medida a los polifenoles, que son parte constituyente de la cáscara y pulpa de la papa y cuyo rol es limpiar de los radicales libres al producto y mantenerlo en buen estado de conservación (22) . Al igual que otros productos vegetales, como frutas y verduras, su concentración y capacidad funcional dependen del grado de maduración (23) .…”

Section: Discussionunclassified

Efecto antioxidante y citoprotector del Solanum tuberosum (papa) en la mucosa gástrica de animales de experimentación

et al. 2011

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ResumenIntroducción: Existen alternativas terapéuticas con productos naturales oriundos usados de manera empírica en la población. Tal es el caso del zumo de papa (Solanum tuberosum) usado para problemas de mucosa gástrica. Objetivos: Evaluar la capacidad antioxidante y el efecto citoprotector a la mucosa gástrica del zumo de papa (Solanum tuberosum). Diseño: Experimental. Institución: Centro de Investigación de Bioquímica y Nutrición de la Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima. Materiales biológicos: Solanum tuberosum, variedad Tomasa y ratas albinas machos. Métodos: Se administró vía oral post ayuno las fracciones de sobrenadante y sedimento del zumo de Solanum tuberosum. Una hora después se administró alcohol como injuria de mucosa gástrica. Por laparotomía abdominal se obtuvo el tejido gástrico. Se midió en la mucosa gástrica el estrés oxidativo por lipoperoxidación, la formación de moco por alcian blue y la protección midiendo la extensión del área lacerada en imagen digitalizada. Principales medidas de resultados: Capacidad antioxidante y efecto citoprotector a la mucosa gástrica. Resultados: El sobrenadante de la dosis 5 mL/ kg produjo mayor protección al estrés oxidativo; el precipitado en dosis 5 mL/kg presentó mayor producción de moco, sin superar al control. El precipitado 20 mL/kg produjo mayor citoprotección (73,8%). Conclusión: La fracción sobrenadante del zumo de la papa (Solanum tuberosum) posee actividad de defensa antioxidante y la fracción del sedimento, mayor actividad citoprotectora de la mucosa gástrica. Palabras clave: Mucosa gástrica; citoprotección; Solanum tuberosum; antioxidantes. AbstractBackground: There are therapeutic alternatives in Peru with empirical native products such as potato juice. Objectives: To assess the antioxidant capacity and the gastric mucosa cytoprotection effect by Solanum tuberosum juice. Design: Experimental. Institution: Research Center of Biochemistry and Nutrition, Faculty of Medicine, Universidad Nacional Mayor de San Marcos. Biological materials: Solanum tuberosum, tomasa variety, and male albino rats. Methods: Oral solid fractions of supernatant and sediment from Solanum tuberosum juice were administered to fasting rats and an hour later, alcohol was given for gastric injury; gastric tissue was obtained by laparotomy. Oxidative stress was measured in the gastric mucosa by lipoperoxidation, formation of mucus by alcian blue, and the extent of protection by measuring lacerated areas in scanned image. Main outcome measures: Antioxidant capacity and gastric mucosa cytoprotection. Results: The 5 mL/kg supernatant produced greater oxidative stress protection; the 5 mL/kg pellet dose showed increased production of mucus, without exceeding controls. The 20 mL/kg precipitate produced greater cytoprotection, 73,8%. Conclusion: Supernatant fraction of Solanum tuberosum juice has antioxidant effect and the fraction of the sediment increased cytoprotective activity on gastric mucosa.

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Section: Discussionunclassified

Efecto antioxidante y citoprotector del Solanum tuberosum (papa) en la mucosa gástrica de animales de experimentación

et al. 2011

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“…Silymarin is an active principle that possesses hepatoprotector and regenerative action; its mechanism of action derives from its capacity to counterarrest the action of FR, which are formed due to the action of toxins that damage the cell membranes (lipid peroxidation), competitive inhibition through external cell membrane modification of hepatocytes; it forms a complex that impedes the entrance of toxins into the interior of liver cells and, on the other hand, metabolically stimulates hepatic cells, in addition to activating RNA biosythesis of the ribosomes, stimulating protein formation. In a study published by [41], the authors observed that silymarin's protector effect on hepatic cells in rats when they employed this as a comparison factor on measuring liver weight/animal weight % (hepatomegaly), their values always being less that those of other groups administered with other possibly antioxidant substances; no significant difference was observed between the silymarin group and the silymarin-alcohol group, thus demonstrating the protection of silymarin. On the other hand, silymarin diminishes Kupffer cell activity and the production of glutathione, also inhibiting its oxidation.…”

Section: Antioxidant and Hepatoprotector Actionmentioning

confidence: 99%

“…In general, it possesses functions such as its antioxidant one, and it can diminish hepatic damage because of its cytoprotection as well as due to its inhibition of Kupffer cell function. [41].…”

Section: Silimarina (Silybum Marianum)mentioning

confidence: 99%

Protective Effect of Silymarin on Liver Damage by Xenobiotics

Morales-González¹,

Gayosso-Islas²,

Moreno³

et al. 2013

Oxidative Stress and Chronic Degenerative Diseases - A Role for Antioxidants

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“…Grape juice has also shown to protect against alcohol intoxication by inhibiting production of ethanol-induced free radicals [84]. The active components present in grape juice and grape seed extract Vitis vinifera L. are flavonoids, such as catechins, epicatechins, anthocyanidins, proanthocyanidins, and resveratrol [85,86].…”

Section: Plant Extracts and Plant Concoctionsmentioning

confidence: 99%

Preventing and Mitigating Alcohol Toxicity: A Review on Protective Substances

2018

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This review covers three fundamental aspects of alcohol consumption and research efforts around the prevention and mitigation of its toxic effects in the human body. First, the sociocultural aspects of alcohol consumption are analysed, including drinking habits and strategies to combat intoxication. Second, we briefly introduce the biochemical aspects of ethanol metabolism and the biochemical pathways leading to its degradation, particularly the activation of toxic response pathways. Finally, we review current evidence and research efforts for finding compounds and substances able to prevent and mitigate the toxic effects of alcohol when over-indulgence has occurred. The toxic effects appear as a time-evolution process based on the stage of intoxication. We explore different compounds and formulations traditionally used to combat alcohol toxicity, as well as state-of-the-art research in the topic for novel molecules and formulations. Although we aimed to categorise which compounds are more effective for a particular level of alcohol intoxication, it is impossible to fully prevent or mitigate toxicity effects by only the compounds in isolation, further research is required to establish the long-term prevention and mitigation from the clinical point of view.

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Hepatoprotección antioxidante de la cáscara y semilla de Vitis vinifera L. (uva)

Cited by 8 publications

References 22 publications

Efecto antioxidante y citoprotector del Solanum tuberosum (papa) en la mucosa gástrica de animales de experimentación

Efecto antioxidante y citoprotector del Solanum tuberosum (papa) en la mucosa gástrica de animales de experimentación

Protective Effect of Silymarin on Liver Damage by Xenobiotics

Preventing and Mitigating Alcohol Toxicity: A Review on Protective Substances

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