Hepatopathology of flaviviruses

Bailey, Adam L.; Diamond, Michael S.

doi:10.1016/j.jhep.2022.05.024

Cited by 3 publications

(1 citation statement)

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“…O gênero Flavivirus compreende um grupo de vírus de RNA, transmitidos por vetores artrópodes, que causam um amplo espectro de doenças potencialmente graves, que incluem as febres hemorrágicas (125), choque (126), encefalites (127), anormalidades congênitas (128), que podem culminar em casos fatais (3,129). Este amplo espectro clínico para apresentação da doença que podem ser causadas por diferentes Flavivirus, refletem principalmente o potencial tropismo celular característico de cada espécie viral, além da capacidade de antagonizar a imunidade do hospedeiro (130).…”

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Análise sistêmica de tecido cerebral em pacientes com morte associada ao vírus febre amarela

Pereira

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Section: Discussionunclassified

Análise sistêmica de tecido cerebral em pacientes com morte associada ao vírus febre amarela

Pereira

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Single‐cell sequencing reveals the features of adaptive immune responses in the liver of a mouse model of dengue fever

Yuan,

Chen,

et al. 2024

Anim Models and Exp Med

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BackgroundDengue fever, an acute insect‐borne infectious disease caused by the dengue virus (DENV), poses a great challenge to global public health. Hepatic involvement is the most common complication of severe dengue and is closely related to the occurrence and development of disease. However, the features of adaptive immune responses associated with liver injury in severe dengue are not clear.MethodsWe used single‐cell sequencing to examine the liver tissues of mild or severe dengue mice model to analyze the changes in immune response of T cells in the liver after dengue virus infection, and the immune interaction between macrophages and T cells. Flow cytometry was used to detect T cells and macrophages in mouse liver and blood to verify the single‐cell sequencing results.ResultsOur result showed CTLs were significantly activated in the severe liver injury group but the immune function‐related signal pathway was down‐regulated. The reason may be that the excessive immune response in the severe group at the late stage of DENV infection induces the polarization of macrophages into M2 type, and the macrophages then inhibit T cell immunity through the TGF‐β signaling pathway. In addition, the increased proportion of Treg cells suggested that Th17/Treg homeostasis was disrupted in the livers of severe liver injury mice.ConclusionsIn this study, single‐cell sequencing and flow cytometry revealed the characteristic changes of T cell immune response and the role of macrophages in the liver of severe dengue fever mice. Our study provides a better understanding of the pathogenesis of liver injury in dengue fever patients.

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A Prototype-Pathogen Approach for the Development of Flavivirus Countermeasures

Kuhn,

Barrett,

Desilva

et al. 2023

The Journal of Infectious Diseases

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Flaviviruses are a genus within the Flaviviridae family of positive-strand RNA viruses and are transmitted principally through mosquito and tick vectors. These viruses are responsible for hundreds of millions of human infections worldwide per year that result in a range of illnesses from self-limiting febrile syndromes to severe neurotropic and viscerotropic diseases and, in some cases, death. A vaccine against the prototype flavivirus, yellow fever virus, has been deployed for 85 years and is highly effective. While vaccines against some medically important flaviviruses are available, others have proven challenging to develop. The emergence and spread of flaviviruses, including dengue virus and Zika virus, demonstrate their pandemic potential. This review highlights the gaps in knowledge that need to be addressed to allow for the rapid development of vaccines against emerging flaviviruses in the future.

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Hepatopathology of flaviviruses

Cited by 3 publications

References 10 publications

Análise sistêmica de tecido cerebral em pacientes com morte associada ao vírus febre amarela

Análise sistêmica de tecido cerebral em pacientes com morte associada ao vírus febre amarela

Single‐cell sequencing reveals the features of adaptive immune responses in the liver of a mouse model of dengue fever

A Prototype-Pathogen Approach for the Development of Flavivirus Countermeasures

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