Hepatoid Carcinoma of the Pancreas: A Case Report

Tomboravo, Christian; Narindra, Lova Hasina Rajaonarison Ny Ony; Ranoharison, Hasina Dina; Ahmad, Ahmad

doi:10.36959/829/398

Cited by 2 publications

(3 citation statements)

References 13 publications

(30 reference statements)

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“…HC has a histological appearance of proliferating large tumor cells, with a trabecular pattern of large polygonal cells seen with abundant eosinophilic cytoplasm, central nuclei, and nucleoli [ 12 ]. A majority of PHC cases have elevated serum AFP levels, hence it can be used as a marker to determine the success of surgery or response to chemotherapy [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

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Focal Hepatocellular Carcinoma in Pancreas

Ahmed,

Sakhawat,

Malik

et al. 2024

J Med Cases

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A 67-year-old man was found to have a pancreatic head mass on abdominal ultrasound. He had compensated liver cirrhosis due to hepatitis C. The fine-needle aspiration (FNA) biopsy of the mass reported an adenocarcinoma of the pancreas, while the subsequent histopathology report of the supraclavicular lymph node showed features of hepatocellular carcinoma (HCC). A second read and additional stains on the FNA specimen confirmed a hepatoid (hepatocellular) carcinoma of the pancreas. He received atezolizumab and bevacizumab and had a good response. Tumors with features of HCC outside of the liver rarely occur and even more rarely in pancreas, with less than 50 cases reported so far. Pure HCC-like morphology is the most common histological form among four subtypes and has a relatively better prognosis. Surgical resection is considered the treatment of choice if amenable and variable outcomes are reported with different chemotherapies. Challenges exist in the diagnosis and the management of this rare and intriguing entity, and the potential misdiagnosis can have grave consequences as the management is completely different for a pancreatic adenocarcinoma and hepatoid carcinoma. We report a case with a challenging diagnosis of metastatic pancreatic hepatoid carcinoma which was treated as unresectable HCC with immunotherapy and the patient had a good response.

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Section: Discussionmentioning

confidence: 99%

“…There is no consensus on treatment protocol due to limited number of cases reported in the literature. Surgical resection is considered the preferred option [ 4 , 12 ]. Oral multitarget tyrosine kinase inhibitor, sorafenib, resulted in a 7-month progression-free survival, in a case of metastatic PHC [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Focal Hepatocellular Carcinoma in Pancreas

Ahmed,

Sakhawat,

Malik

et al. 2024

J Med Cases

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“…Hepatoid carcinomas (HCs) are a group of heterogeneous tumors that represent the morphology and immunohistochemistry of focal hepatocellular carcinoma (HCC), which comprises of pure forms of HC or a combination of other morphological features of acinar cell carcinomas, endocrine tumors or ductal adenocarcinomas. It has been reported in different primary sites of various cell origins, including the stomach, esophagus, lungs, gallbladder, urinary bladder, colon, ampulla of Vater, uterus, fallopian tubes, adrenal gland, ovaries, thymus, biliary tract, and other sites (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16). Since Hruban et al (17) first reported primary pancreatic hepatoid carcinoma (PHC) in 1987, only 41 cases of primary PHC have been reported in the English literature, at least to the best of our knowledge (4,.…”

Section: Introductionmentioning

confidence: 99%

Pancreatic hepatoid carcinoma: A case report and literature review

et al. 2021

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Hepatoid carcinomas (HCs) are a group of heterogeneous tumors that are similar to hepatocellular carcinoma (HCC). Pancreatic hepatoid carcinoma (PHC) is a very rare disease. The present study presents the case of a 63-year-old male patient with PHC with synchronous liver, spleen and stomach metastasis, in an aim to enhance our understanding of this disease. A 63-year-old male presented with abdominal distension for 3 months and slightly developed asthenia and anorexia. Laboratory tests of serum tumor markers revealed the alpha fetoprotein level was markedly elevated (>10,00.0 ng/ml). The radiological findings of computed tomography, magnetic resonance imaging, diffusion-weighted imaging and magnetic resonance cholangiopancreatography revealed a malignant tumor in the tail of the pancreas with synchronous liver, spleen, stomach and retroperitoneal lymph node metastasis. A post-operative immunohistochemical analysis revealed that the tumor cells in the tail of the pancreas exhibited positivity for glypican-3; right liver positivity was also observed for CK-18 and weak positivity for glypican-3, suggestive of primary PHC. On the whole, PHC is very rare, and exhibits morphological features similar to those of HCC. Its diagnosis is mainly achieved via morphological analysis and immunohistochemical staining of the tissue specimens, since the clinical manifestation and laboratory test results are often unspecific.

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Hepatoid Carcinoma of the Pancreas: A Case Report

Cited by 2 publications

References 13 publications

Focal Hepatocellular Carcinoma in Pancreas

Focal Hepatocellular Carcinoma in Pancreas

Pancreatic hepatoid carcinoma: A case report and literature review

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