Hepatoid adenocarcinoma of the transverse colon

Slotta, Jan E.; Jüngling, B.; Kim, Yoo Jin; Wagner, Mathias; Igna, Dorian; Schilling, Martin K.

doi:10.1007/s00384-011-1305-6

Cited by 15 publications

(11 citation statements)

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“…In this study, we report one case of HAC and further reviewed the clinicopathological characteristics of the previously published 17 patients with colorectal HAC (Table 1, [6-22]). Colorectal HAC commonly occurs in middle age to old patients (median age: 54 years; range: 36 - 75) and shows a predilection for the male sex.…”

Section: Discussionmentioning

confidence: 99%

“…A number of reported HAC cases underwent treatment using the regimen of FOLFOX (leucovorin, 5-fluorouracil, and oxaliplatin) or FOLFIRI (leucovorin, 5-fluorouracil, irinotecan). In a patient of HAC of the transverse colon without liver and lymph nodes metastasis, combination of a radical resection and adjuvant chemotherapy of FOLFOX-4 regimen had led to a recurrence-free survival of 27 months [6]. It is possible that since HAC is pathologically similar to HCC, agents used in primary HCC may be effective in HAC.…”

Section: Discussionmentioning

confidence: 99%

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Liver Metastasis of Hepatoid Colonic Adenocarcinoma: A Rare and Unusual Entity With Poor Prognosis and Review of the Literature

Liu

Yin

et al. 2018

Gastroenterol Res

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Hepatoid adenocarcinoma (HAC) is rare and was first reported as α-fetoprotein (AFP)-producing tumor. It is an important variant of extrahepatic adenocarcinoma with clinicopathological presentation mimicking hepatocellular carcinoma and carries exceedingly poor prognosis. HAC most commonly originates in the stomach, and less commonly in the ovary, esophagus, lung, among other organs. HAC originating in the colon is exceedingly rare. Here we report such a case of a 63-year-old man presented as decompensated liver failure with jaundice and weakness. Computed tomography (CT) imaging findings showed multiple lesions in the liver with ascites and descending colonic mass suspicious for malignancy. The flexible sigmoidoscopy showed a 1.5 cm mass in the descending colon, and biopsy showed superficial fragments of tubular adenoma, but could not exclude deep invasive carcinoma. A liver biopsy was performed and showed a carcinoma with morphologic features resembling hepatocellular carcinoma. The tumor cells were positive for glypican-3, MOC31, CDX2, SATB2 and CK20, negative for arginase-1, p63, synaptophysin and chromogranin. Ki-67 highlighted 80% of the tumor cells. The pathology diagnosis was liver with metastatic hepatoid adenocarcinoma consistent with colonic primary. The patient experienced a rapid worsening of his liver function and died 3 weeks later of hepatic failure without any surgery and chemotherapy. A subsequent literature review of the 17 reported cases of HAC showed that this type of cancer frequently metastasizes to the liver with an astonishingly poor prognosis with eight patients died of the disease in less than 5 months after the diagnosis was made. Radical surgery followed by adjuvant chemotherapy with chemotherapy regimen used for colorectal cancer or primary hepatocellular carcinoma may be the treatment option for colorectal HAC.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Liver Metastasis of Hepatoid Colonic Adenocarcinoma: A Rare and Unusual Entity With Poor Prognosis and Review of the Literature

Liu

Yin

et al. 2018

Gastroenterol Res

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“…The serum AFP level remained within the normal range. In general, although HAL is usually associated with poor prognosis, for early stage HAL patents, radical surgical resection may markedly increase the cure rate (3,15,17,19). Even for patients in whom lymph node or distant metastases are detected, palliative lobectomy and adjuvant chemoradiation are considered appropriate treatments to improve the survival time (10)(11)(12)20).…”

Section: Discussionmentioning

confidence: 99%

Hepatoid adenocarcinoma of the lung without production of α-fetoprotein: A case report and review of the literature

Sun

Zhang

et al. 2016

Oncology Letters

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Abstract. Hepatoid adenocarcinoma of the lung (HAL) is a rare type of extrahepatic hepatoid adenocarcinoma. The majority of such cases that have been reported in the English literature have demonstrated elevated serum α-fetoprotein (AFP) and/or positive AFP expression on histopathological analysis, and have had poor prognoses. The current study reports an extremely rare case of HAL in the right upper lung without AFP production in a 59-year-old male patient. The patient underwent radical right upper lobectomy via video assisted thoracoscopic surgery. No signs of local recurrence or distant metastasis have been observed for 23 months after the surgery. The serum AFP level following surgery remained within the normal range. Although the diagnosis of HAL predominantly depends on pathological examination, a review of the literature demonstrates that HAL has certain characteristic features with regard to its clinical and computed tomography findings and prognoses, and clinicians should be aware that clinicians should be aware that monitoring serum AFP levels, as well as CT findings, remains important.

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“…Typically defined as a neoplasm with features of hepatocellular carcinoma outside of the liver, hepatoid carcinoma has been found in multiple organs as a primary tumor [1, 7, 17, 18, 19]. Clinically, patients with hepatoid carcinoma are typically middle-aged to older, and may demonstrate higher serum AFP levels and nonspecific symptoms [20].…”

Section: Discussionmentioning

confidence: 99%

Hepatoid Carcinoma of the Pancreas: Case Report, Next-Generation Tumor Profiling, and Literature Review

Chang

Katariya

Lam-Himlin

et al. 2016

Case Rep Gastroenterol

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Fewer than 25 cases of hepatoid carcinoma of the pancreas have been reported in the literature. We present a case in a 61-year-old male with a remote history of Hodgkin’s lymphoma and gastric neuroendocrine cell hyperplasia. On surveillance endoscopic ultrasound, an 8 × 5 mm cystic lesion was seen in the tail of the pancreas. MRI showed a focal pancreatic duct cut-off with mild ductal dilation. Fine needle aspiration was performed, which was concerning for acinar cell carcinoma. The patient underwent distal pancreatectomy and recovered uneventfully. Final pathology demonstrated a 1.3-cm hepatoid carcinoma of the pancreas, with a final clinicopathological stage of T1N0M0. Next-generation nucleic acid sequencing of the tumor did not suggest a viable adjuvant chemotherapeutic agent, and no adjuvant therapy was administered. The patient has no evidence of disease 6 months following resection. A further characterization and description of the outcomes of these rare tumors is warranted to help guide providers and counsel patients.

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Hepatoid adenocarcinoma of the transverse colon

Cited by 15 publications

References 0 publications

Liver Metastasis of Hepatoid Colonic Adenocarcinoma: A Rare and Unusual Entity With Poor Prognosis and Review of the Literature

Liver Metastasis of Hepatoid Colonic Adenocarcinoma: A Rare and Unusual Entity With Poor Prognosis and Review of the Literature

Hepatoid adenocarcinoma of the lung without production of α-fetoprotein: A case report and review of the literature

Hepatoid Carcinoma of the Pancreas: Case Report, Next-Generation Tumor Profiling, and Literature Review

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