Hepatoid Adenocarcinoma of Stomach: Emphasis on the Clinical Relationship with Alpha-Fetoprotein-Positive Gastric Cancer

Chen, Er‐Bao; Wei, Yimin; Liu, Hai-Ning; Tang, Cheng; Liu, Meng-Ling; Peng, Ke; Liu, Tianshu

doi:10.1155/2019/6710428

Cited by 15 publications

(15 citation statements)

References 29 publications

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“…Previously, there were few studies on HAC, which made the differential diagnosis more difficult. With the increasing cognition of the special clinical and pathological features of HAC, the diagnosis rate of HAC also gradually increased ( 4 , 5 ).…”

Section: Discussionmentioning

confidence: 99%

Incidence and prognostic factors of hepatoid adenocarcinoma: a population-based analysis

Wang¹,

Li²

2020

Transl Cancer Res TCR

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Background: Hepatoid adenocarcinoma (HAC) is a kind of rare extrahepatic adenocarcinoma with hepatocyte differentiation. At present, the incidence and prognostic factors of HAC remain poorly discussed.Methods: We extracted two cohorts from Surveillance, Epidemiology, and End Results (SEER) database by restricting the histology to HAC. One cohort of 258 eligible patients was from SEER 21 Regs Limited-Field Research Data + Hurricane Katrina Impacted Louisiana Cases [2000][2001][2002][2003][2004][2005][2006][2007][2008][2009][2010][2011][2012][2013][2014][2015][2016] to compute incidence, and the other cohort of 121 eligible patients was from SEER 18 Regs Custom Data (with additional treatment fields) to estimate survival and risk factors. The incidence wad computed by the Joinpoint Regression Program (Version 4.7.0.0). The overall survival (OS) and prognostic factors were analyzed by univariate and multivariate analyses in SPSS 24.0. Results:The overall incidence of HAC between 2000 and 2016 was 0.014 per 100,000 people (95% CI: 0.012 to 0.015). The most common primary site was the lung, followed by the digestive, urinary and reproductive organs, but in the previously published case reports, the stomach was the most common site.The median age at diagnosis was 66 (range, 31-85) years. A total of 28.1% of patients underwent surgery, while 71.9% underwent radiotherapy or/and chemotherapy. The 1-year survival rate of these patients was 35.0%, and the 3-year survival rate was only 16.9%. The median survival time was 5 months (95% CI: 2.97 to 7.03 months). Multivariate analysis showed that age less than 60 years, no distant metastasis, surgery and chemotherapy were independent prognostic factors related to a better outcome.Conclusions: This study suggests that HAC is a rare malignant tumor with poor prognosis, and its most common site is lung. Its incidence is increasing year by year. Age at diagnosis, distant metastases, surgery, and chemotherapy were independent prognostic factors.

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Section: Discussionmentioning

confidence: 99%

Incidence and prognostic factors of hepatoid adenocarcinoma: a population-based analysis

Wang¹,

Li²

2020

Transl Cancer Res TCR

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“…The most common sites in which HAC developed include LNs, liver, lungs, peritoneum, and the spleen from existing literature (2,37). Lacking specific clinical symptoms, the clinical manifestation of HAS is similar to common gastric cancer with many initial symptoms cover epigastric pain (55), abdominal distention (8), backache (55), fatigue (56), reduced appetite, weight loss (57), hematochezia, hematemesis (57) and shortness of breath (58). The most common presentation of HAS is abdominal pain (Table 1).…”

Section: Clinical Presentationsmentioning

confidence: 99%

“…Also, the patients with higher AFP expression had a significantly more inferior OS (58). AFP was assumed to be adverse to tumor suppression due to inhibiting lymphocyte transformation (27).…”

Section: Prognostic Factorsmentioning

confidence: 99%

Hepatoid Adenocarcinoma of the Stomach: Current Perspectives and New Developments

et al. 2021

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Hepatoid adenocarcinoma of the stomach (HAS) is a rare malignant tumor, accounting for only 0.17–15% of gastric cancers. Patients are often diagnosed at an advanced disease stage, and their symptoms are similar to conventional gastric cancer (CGC) without specific clinical manifestation. Morphologically, HAC has identical morphology and immunophenotype compared to hepatocellular carcinoma (HCC). This is considered to be an underestimation in diagnosis due to its rare incidence, and no consensus is reached regarding therapy. HAS generally presents with more aggressive behavior and worse prognosis than CGC. The present review summarizes the current literature and relevant knowledge to elaborate on the epidemic, potential mechanisms, clinical manifestations, diagnosis, management, and prognosis to help clinicians accurately diagnose and treat this malignant tumor.

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“…Hepatoid adenocarcinoma (HAC) is a rare tumor with extrahepatic origin, characterized by the imitation of the morphological phenotype of hepatocellular carcinoma (HCC). Hepatoid adenocarcinoma not only shares the morphological features of HCC, but its alpha-fetoprotein (AFP) production and immunohistochemical properties resembles HCC (9,10) . While hepatoid adenocarcinoma is seen in many organs such as the lung, pancreas, ovary, uterus and gall bladder, the most frequently affected organ is the stomach.…”

Section: Introductionmentioning

confidence: 99%

“…While hepatoid adenocarcinoma is seen in many organs such as the lung, pancreas, ovary, uterus and gall bladder, the most frequently affected organ is the stomach. It accounts for only 0.38 to 1.00% of all gastric cancers (GC) (9,11) . HAC is an aggressive tumor with a poor prognosis that tends to metastasize to the liver and lung at an early stage (12) .…”

Section: Introductionmentioning

confidence: 99%

Review of the Clinicopathological Features and Prognosis of the Rare Histological Types of Gastric Cancer

Talih¹,

Topal²,

Sözüer³

et al. 2020

BMJ

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Objective: Gastric cancer consists of many histological subtypes. Prognostic value of histological types in gastric cancer has not been very well defined. In this study, we aimed to investigate the relationship between different histological types and clinicopathologic features and prognosis in gastric cancer. Method: Patients whose pathological diagnosis was adenosquamous carcinoma, hepatoid adenocarcinoma, lymphoepithelioma-like carcinoma, and papillary adenocarcinoma, among the 1060 patients who underwent gastrectomy for gastric cancer between 2010-2019, were included in the study. Demographic features, clinicopathological features, oncological follow-up results and survival of the patients were analyzed. Results: Group 1 (adenosquamous carcinoma) consisted of 3, Group 2 (hepatoid adenocarcinoma) of 3, Group 3 (lymphoepithelioma-like carcinoma) of 3, and Group 4 (papillary adenocarcinoma) consisted of 4 patients. The mean age of the patients included in the study was 63.3+11.76 (41-81) years. Tumors were more commonly located in the corpus in hepatoid adenocarcinoma and lymphoma-like carcinoma (67%) and in the antrum (75%) in papillary adenocarcinoma. Eight patients underwent total gastrectomy, four patients subtotal gastrectomy, and a patient with a tumor located at the gastroesophageal junction underwent proximal gastrectomy. Average tumor size (cm) was 5.11+2.23 (1.2-8) cm. Local recurrence occurred in two patients with adenosquamous carcinoma, two with hepatoid adenocarcinoma, and one with papillary adenocarcinoma. Two patients with adenosquamous carcinoma developed systemic metastasis (lung, liver), two patients with hepatoid adenocarcinoma developed peritoneal carcinomatosis, and a patient with papillary adenocarcinoma developed surrenal metastasis. Average survival was the shortest in hepatoid adenocarcinoma (17.50 months), and the longest in papillary adenocarcinoma (63 months). There was no statistical difference in survival between the groups (p: 0.445). Conclusion: Rare histological types of the stomach differed in terms of their locations and prognoses. Among the rare histological types, hepatoid adenocarcinoma exhibited the most aggressive biological behavior, while patients with papillary adenocarcinoma had longer survival times.

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Hepatoid Adenocarcinoma of Stomach: Emphasis on the Clinical Relationship with Alpha-Fetoprotein-Positive Gastric Cancer

Cited by 15 publications

References 29 publications

Incidence and prognostic factors of hepatoid adenocarcinoma: a population-based analysis

Incidence and prognostic factors of hepatoid adenocarcinoma: a population-based analysis

Hepatoid Adenocarcinoma of the Stomach: Current Perspectives and New Developments

Review of the Clinicopathological Features and Prognosis of the Rare Histological Types of Gastric Cancer

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