Hepatocyte transplantation: Potential of hepatocyte progenitor cells and bone marrow derived stem cells

Stieger, Bruno; Peters, Rowayda; Sidler, Marguerite-Anne; Meier, Peter J.

doi:10.4414/smw.2006.11419

Cited by 5 publications

(1 citation statement)

References 38 publications

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“…These techniques for isolating hepatocytes are widely used [19] . During isolation, precautions should be taken to reduce cell damage and maintain cell viability and adherence [20][21][22] .…”

Section: Current Status Of Hepatocyte Transplantationmentioning

confidence: 99%

Advances in Cell Therapy for Liver Regeneration

Bai,

Cheng Jin

2023

ghl

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With the development of translational medicine, cell therapy has been applied in clinical practice, especially in the regenerative treatment of severe liver diseases. This article introduces the origin, development, and prospects of cell therapy from the aspects of liver disease treatment, history, current status, and clinical application feasibility of cell therapy. The article also points out the existing problems in the translational medical research of cell therapy. To achieve a favorable development in cell therapy, more fundamental and clinical are warranted.

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Section: Current Status Of Hepatocyte Transplantationmentioning

confidence: 99%

Advances in Cell Therapy for Liver Regeneration

Bai,

Cheng Jin

2023

ghl

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Liver regeneration: Alternative epithelial pathways

Michalopoulos

2011

The International Journal of Biochemistry & Cell Biology

113

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Loss of hepatic tissue triggers a regenerative response in the whole organ. Under typical normal conditions, all hepatic cells (epithelial: hepatocytes and biliary epithelial cells; non-epithelial: stellate cells, macrophages and endothelial cells) undergo one to three rounds of replication to establish the original number of cells and restore organ size. The review summarizes the literature of regenerative patterns in situations in which proliferation of either hepatocytes or biliary epithelial cells is inhibited. The evidence strongly suggests that under these circumstances, hepatocytes or biliary epithelial cells can function as facultative stem cells for each other and replenish the inhibited cellular compartment by a process of trans-differentiation, involving complex signaling pathways. These pathways are activated under experimental conditions in rodents and in fulminant hepatitis associated with liver failure in humans. Mechanistic analysis of these pathways has implications for liver biology and for potential therapeutic modalities in human liver disease.

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Acute liver failure: Bridging to transplant or recovery– are we there yet?

Singhal

Neuberger

2007

Journal of Hepatology

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Hepatocyte transplantation: Potential of hepatocyte progenitor cells and bone marrow derived stem cells

Cited by 5 publications

References 38 publications

Advances in Cell Therapy for Liver Regeneration

Advances in Cell Therapy for Liver Regeneration

Liver regeneration: Alternative epithelial pathways

Acute liver failure: Bridging to transplant or recovery– are we there yet?

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