“…Transdifferentiation of pancreatic ceils to hepatocytes in the pancreas of rats and hamsters has been observed under various experimental conditions (4,8,15,22,23,24,26,27,33). The copper depletion and repletion model of pancreatic hepatocytes (26,28) uses copper-deficient diet (20) supplemented with trien, a mild nontoxic copper chelator (35).…”