Hepatocyte growth factor/scatter factor (HGF/SF) in early development: evidence for a role in neural induction

Bronner‐Fraser, Marianne

doi:10.1016/s0168-9525(00)89136-2

Cited by 12 publications

(10 citation statements)

References 15 publications

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“…Plasminogen and its activators are associated with cell migration and tissue remodelling in processes such as neurogenesis and organogenesis, although the developmental expression is complex and not restricted to ectoderm-derived tissues (Moonen et al 1982;Menoud et al 1989;Sumi et al 1992). HGF is also expressed in a complex and changing pattern during development in neural, epithelial and mesodermal tissues, and has both mitogenic and cell scattering properties (reviewed in Warn 1994;Bronner-Fraser 1995).…”

Section: Discussionmentioning

confidence: 99%

Transient expression of a novel serine protease in the ectoderm of the ascidian Herdmania momus during development

Arnold

Kennett

Degnan

et al. 1997

Development Genes and Evolution

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We have studied gene expression during ascidian embryonic development using the technique of differential display and isolated partial cDNA sequences of 12 genes. Developmental regulation of these genes has been confirmed by northern hybridization analysis. Further cDNA cloning and sequence analysis of an mRNA that is present during gastrulation, neurulation and tailbud formation reveals that it encodes a novel serine protease containing a single kringle motif and catalytic domain. The spatial expression of this gene, designated Hmserp1, is restricted to precursor cells of the epidermis. The structure and expression of Hmserp1 is discussed in relation to possible functions during development.

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Section: Discussionmentioning

confidence: 99%

Transient expression of a novel serine protease in the ectoderm of the ascidian Herdmania momus during development

Arnold

Kennett

Degnan

et al. 1997

Development Genes and Evolution

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“…There is strong molecular and cellular basis for this hypothesized mis-wiring. MET signaling is required for multiple neurodevelopmental events, including neuronal lineage commitment and survival (Bronner-Fraser, 1995; Streit et al, 1995), proliferation (Ieraci et al, 2002), migration (Garzotto et al, 2008; Giacobini et al, 2007; Krasnoselsky et al, 1994; Powell et al, 2001; Segarra et al, 2006), neurite outgrowth (Gutierrez et al, 2004; Maina et al, 1997; Tyndall, Patel, & Walikonis, 2007), sensorimotor axon pathfinding (Caton et al, 2000; Ebens et al, 1996; Powell, Muhlfriedel, Bolz, & Levitt, 2003), and neuronal repair and survival (Maina et al, 1997, 1998; Miyazawa et al, 1998; Wong et al, 1997; Yamamoto et al, 1997). MET signaling in vitro enhances axon outgrowth, dendritogenesis, and synaptogenesis (Ebens et al, 1996; Gutierrez et al, 2004; Tyndall et al, 2007).…”

Section: Implication Of Met Signaling In Neural Development and Fumentioning

confidence: 99%

MET Receptor Tyrosine Kinase as an Autism Genetic Risk Factor

Peng

Huentelman

Smith

et al. 2013

International Review of Neurobiology

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In this chapter, we will briefly discuss recent literature on the role of MET receptor tyrosine kinase (RTK) in brain development and how perturbation of MET signaling may alter normal neurodevelopmental outcomes. Recent human genetic studies have established MET as a risk factor for autism, and the molecular and cellular underpinnings of this genetic risk are only beginning to emerge from obscurity. Unlike many autism risk genes that encode synaptic proteins, the spatial and temporal expression pattern of MET RTK indicates this signaling system is ideally situated to regulate neuronal growth, functional maturation, and establishment of functional brain circuits, particularly in those brain structures involved in higher levels of cognition, social skills, and executive functions.

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“…The recent observation that Ras activation of Rac is mediated by phosphatidylinositol 3-kinase, is also in line with previous findings that chemotaxis toward PDGF is phosphatidylinositol 3-kinase-dependent (20 -22). Interestingly, Ras, phosphatidylinositol 3-kinase, and Rac have also been shown to be necessary for hepatocyte growth factor/scatter factor-induced dispersion of Madin-Darby canine kidney cells (31)(32)(33), indicating that this signaling cascade may be utilized in a variety of motile responses and may play an important role in mammalian development (34).…”

Section: Inhibition Of the Erk Pathway Impairs Directed Migration Towmentioning

confidence: 99%

Platelet-derived Growth Factor and Fibronectin-stimulated Migration Are Differentially Regulated by the Rac and Extracellular Signal-regulated Kinase Pathways

Anand‐Apte

Zetter

Viswanathan

et al. 1997

Journal of Biological Chemistry

163

122

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Directed cell migration is essential for a variety of important biological processes ranging from development and angiogenesis to metastasis. Ras plays a pivotal role in the signaling cascade that governs chemotaxis of fibroblasts toward platelet-derived growth factor-BB (PDGF-BB). Ras activates multiple downstream pathways, which include the extracellular signal-regulated kinase (ERK), Rac, and Ral signaling cascades. We therefore investigated the role of the Rac and ERK pathways in cell migration. We showed that migration of fibroblasts toward PDGF-BB is inhibited by expression of dominant negative Asn-17 Rac1. Blocking of the ERK pathway by either expression of dominant negative Ala-218/Ala-222-mitogen-activated protein kinase kinase (A218/A222-MEK1) or by a MEK-specific inhibitor did not inhibit migration toward PDGF-BB. In contrast, migration toward soluble fibronectin was suppressed by inhibition of the ERK pathway but not by Asn-17 Rac1 expression. These results indicate that directed cell migration mediated by different receptor classes in response to different ligands differentially utilizes the Rac and ERK pathways and suggest that Rac might play a critical role in pathological processes such as angiogenesis and metastasis.Directed cell migration or chemotaxis is a critical feature of several physiological and pathological processes, including development, wound healing, atherosclerosis, immunity, angiogenesis, and metastasis (1-4). Chemotaxis involves the sensing of a concentration gradient of chemoattractant, reorganization of the actin cytoskeleton, and subsequent movement toward the chemoattractant. Cytokine-induced reorganization of the actin cytoskeleton is mediated by members of the Rho family of GTP-binding proteins. Rho regulates stress fiber assembly, Rac controls lamellipodia formation, and Cdc42 directs the dynamics of filipodia (5-8).We have shown previously that the GTP-binding protein Ras plays a central role in the signaling cascade that governs chemotaxis of fibroblasts toward PDGF-BB 1 (9). However, the pathways downstream of Ras that control cell motility remain unknown. Ras activates several distinct effector pathways, including the ERK cascade, the pathway controlled by Rac, and the pathway initiated by RalGDS, the guanine nucleotide dissociation stimulator for RalA and -B, which are close relatives of Ras (10 -17). Since Rac has been shown to control the formation of lamellipodia induced by Ras (5, 18), it is a likely candidate for regulating Ras-mediated directed migration. A possible role for Rac in directed migration is also suggested by observations showing that Ras-and growth factor-induced activation of Rac are mediated by phosphatidylinositol 3-kinase (17, 19), which in turn has been implicated in chemotaxis (20 -22). In this study, therefore, we investigated the role of Rac in different types of cell migration: directed migration toward PDGF-BB and soluble fibronectin and random migration stimulated by lysophosphatidic acid (LPA). EXPERIMENTAL PROCEDURESCell Lines-Derivati...

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Hepatocyte growth factor/scatter factor (HGF/SF) in early development: evidence for a role in neural induction

Cited by 12 publications

References 15 publications

Transient expression of a novel serine protease in the ectoderm of the ascidian Herdmania momus during development

Transient expression of a novel serine protease in the ectoderm of the ascidian Herdmania momus during development

MET Receptor Tyrosine Kinase as an Autism Genetic Risk Factor

Platelet-derived Growth Factor and Fibronectin-stimulated Migration Are Differentially Regulated by the Rac and Extracellular Signal-regulated Kinase Pathways

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